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HUCM Exam 2
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21
Medical
Graduate
08/26/2011

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Term
In TAG Synthesis, in liver and adipose it involves what two things as intermediates?
Definition
Phosphatidate and DAG
Term
In TAG synthesis, in the intestinal mucousa, what two things are the ONLY intermediates?
Definition
DAG and MAG
Term
In TAG synthesis in the liver and adipose it requires what three things?
Definition
Fatty Acyl CoAs, Glycerol-3-PO4, Dihydroxyacetone-PO4
Term
What thing in particular does the liver require for TAG synthesis that adipose tissue does not?
Definition
Glycerol
Term
TAG Synth in Liver
Source of Fatty Acid: ? ? & ? ?
Definition
adipose tissue and liver biosynthesis
Term
TAG synthesis
Tissue: Liver
Utilization:?
Definition
Lipoprotein production (ex. LDL, HDL, and VLDL)
Term
TAG synthesis
Tissue: Liver
Utilization:?
Definition
Lipoprotein production (ex. LDL, HDL, and VLDL)
Term
TAG synthesis
Tissue: Adipose
Source of Fatty Acid: ? & ? ?
Definition
diet and liver biosynthesis
Term
TAG Synthesis
Tissue: Adipose
Utilization: ?
Definition
Storage
Term
TAG synthesis
Tissue: Intestinal Mucousa
Source of Fatty Acid:
Definition
diet
Term
Fatty Acid Synthesis
Tissue: Interstitial Mucousa
utilization ? ?
Definition
chylomicron synthesis
Term
In Fatty Acid Synthesis, what causes the release of CO2?
Definition
beta-ketoacyl ACP synthase
Term
What is the FAS inhibitor that is selectively cytotoxic to cell lines derived from human malignancies?
Definition
Cerulenin
Term
In plasmologens there is an ether linkage at what position?
Definition
Ether
Term
Plasmologens are present in what two types of tissue?
Definition
Myelin and heart tissue
Term
In plasmologens, there is a platelet activating factor with a what group at the #2 position?
Definition
Acetyl Group
Term
One treatment for hypercholesterolemia promotes exretion of bile salts. BUT THE MOST POPULAR ARE?
Definition
HMG CoA inhibitors (statin drugs)
Term
Hypercholesterolemia predisposes patient to ? which can result in ? ?/ ?
Definition
atherosclerosis
myocardial infarction / stroke
Term
In cholesterol synthesis the Rate determining step is as follows

HMG CoA--> _HMG CoA Reductase(enzyme)___> ?
Definition
Mevalonate
Term
What causes free cholesterol and FA to form chol-ester
Definition
ACAT
Term
Down regulation of cholesterol synthesis results in?
Definition
hypercholesterolemia
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