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HTH 471 Biologic Aging Theories and Longevity
Gerontology
63
Health Care
4th Grade
01/28/2013

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Term
Life span
Definition
the theoretical limit on the length of life
Term
What is the longest that people are said to be able to live
Definition
115-120
Term
Life expectancy
Definition
the number of years an individual can expect to live
Term
What is life expectancy based off of
Definition
birth, age, gender, race, culture and health behaviors.
Term
Morbidity
Definition
Period of reduced function, disability and illness
Compression morbidity
Term
Improvements include
Definition
sanitation, vaccinations, antibiotics, increase survival of infants, young children and birthing women.
Term
Actuarial Data
Definition
calculate life expectancy of people from various states, ages, races and educational levels, with several health habits. Then they use the statistics based on groups of people and averages
Term
Animal studies
Definition
changing one variable at a time
Term
Longitudinal studies
Definition
over time
Term
Centenarian studies
Definition
studying individuals who live to be more than 100, their siblings, and their children to try to understand what factors are associated with extreme aging.
Term
Three ways heredity affects longevity
Definition
Parenting styles, old relatives, human genome project
Term
Three reasons why females may live longer than males
Definition
hormones, more risky behavior, x chromosome
Term
Why may minorities experience more health problems
Definition
Minorities are often poor, less educated, have poorer living situation, less insurance, worse diet and worse jobs
Minorities/poor may face higher stress levels and discrimination
Term
What is the leading cause of preventable death in the US?
Definition
smoking
Term
In older people smoking
Definition
Reduces bone density in postmenopausal women
Increases risk of chronic obstructive pulmonary disease
Increases risk of hip fractures
Increases risk of cataracts
Term
65-year old smoker who quits
gains how many years life expectancy
Definition
two
Term
Obesity is correlated with an increased risk of
Definition
premature death and disability
Term
High levels of physical activity are associated with low or high death rates from all causes of mortality?
Definition
Low
Term
Light consumption (1-2 drinks/day) may be associated with
Definition
cardiovascular benefits
Term
Heavy drinking (3+drinks/day) is associated with
Definition
reduced life expectancy
Term
Heavy drinking can cause
Definition
liver damage, nutritional deficiencies, cardiovascular problems, nervous system conditions, suicide, accidents and certain cancers.
Term
People married at the time of their deaths lived longer or shorter than those widowed or divorced?
Definition
Longer
Term
Marriage may promote longevity because
Definition
You have a friend for help and reduction of stress
Marriage promotes healthful habits
Sex is more frequent in a married relationship
Term
Three ways personality may influence longevity
Definition
A negative personality is comparable to high blood pressure
A negative person may also chose life-shortening behaviors
A calm person may live longer
Term
People in middle and upper classes live longer or shorter than those in the lower classes
Definition
longer
Term
More income may mean more money spent on
Definition
health, better living conditions (also health care)
Term
Higher education may mean more
Definition
healthful habits
Term
People from developed countries have higher life expectancy than those from less-developed countries
Often associated with
Definition
high rates of infant and maternal morality
Term
Four more reasons why people in developing countries may live longer than those in less developed countries
Definition
sanitation, prevalence of infectious disease, dietary factors, access to health care
Term
Two things from the environment which hurt health
Definition
radiation and pollution
Term
What does radiation do?
Definition
impairs cell growth and accelerates the aging process
Term
How many types of cells are there in a human body?
Definition
over 200
Term
Genes are located on what and in what
Definition
chromosomes (DNA) and in the nucleas
Term
Genes tell _____ what to do
Definition
cells
Term
cells makes _____
Definition
tissues
Term
tissues make _______
Definition
organs
Term
Organs make ______
Definition
systems
Term
What is the cap at the end of DNA called
Definition
telomere
Term
Mutation
Definition
any alter in the genetic code
Term
How do cells reproduce
Definition
mitosis
Term
What are two examples of cells that are post mitotic
Definition
neurons and some muscle cells
Term
Two phenomena in aging
Definition
A physiological decline in many body systems
An increased prevalence of disease
Term
Two theories of aging
Definition
Random Theory of Aging
Programmed Theory of Aging
Term
Random Theory of Aging
Definition
The environment causes mutations in cells leading to errors and damage to the cells that weaken the ability to function and divide, thus causing aging
Term
In the Random Theory of aging, what makes the chromosomes function less efficiently
Definition
cross linking of DNA
Term
How does DNA crosslink
Definition
radiation and UV light
Term
Wear and Tear Theory suggests
Definition
that years wear cells out
Term
Four Aspects of Random Theory
Definition
-Cross linking
-Wear and Tear
-Free radical
-Accumulation of errors
Term
What is the free radical theory
Definition
Damage from highly reactive molecules within the cell causes aging
Term
What are free radicals
Definition
toxic byproduct of cell metabolism
that are also created through diet or environment
Term
What does the body produce to inactivate free radicals
Definition
enzymes
Term
Free radical damage to the cell’s DNA and less ability to repair damage can lead to
Definition
errors in the genetic material
Term
Examples of enzymes which inactivate free radicals
Definition
-Melatonin produced by the body
-Vit E
-Vit C
-Vit A
-Selenium
Term
What is the accumulation of errors theory
Definition
Accumulation of mutations causes aging
Term
Biological Clock (Pacemaker) Theory
Definition
suggests we are programmed from birth to shut down at a specific time
Term
Hypothalamus links nervous system and endocrine system by
Definition
sending chemical messages to pituitary gland.
Term
Pituitary gland sends messages to
Definition
other endocrine glands of the body
Term
Hypothalamus regulates the hormones of what?
Definition
ovaries, testes, adrenal glands and thyroid glands.
Term
Immune system
Definition
differentiate “foreign” from “self” and combat invaders. As we age, the system declines and produce cells that make mistakes and have a possible increased rate of cancer, inefficiency and cell death.
Term
How many times do cells divide?
Definition
40-60
Term
When the telomere is too short,
Definition
the cell cannot divide
Term
Telomerase
Definition
enzyme that helps keep telomeres long, also found in cancer cells
Term
Five "miracle" ways to extend life
Definition
Anti-aging medicine
caloric restriction
Antioxidant theory
DHEA
HGH
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