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HTH 378 E2 Medication For Mental Disorders
Use and Effects of Drugs
64
Health Care
Undergraduate 3
03/26/2013

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Term
Medical Model
Definition
symptoms 
diagnosis 
determination of cause 
treatment 
cure
Term
Criticisms of model
Definition
Usually the only symptoms of mental disorders are behavioral
Behaviors are varied and can have many causes
Term
Model guides much of
Definition
current thinking
Term
Psychoactive drugs are used to control symptoms of
Definition
mental illness
Term
Researchers seek to identify _______ ___________associated with specific mental disorders
Definition
chemical imbalances
Term
APA Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) provides
Definition
criteria for classifying mental disorders
Includes hundreds of specific diagnostic categories
Widely used classification system
Term
Anxiety disorders
Definition
disorders—characterized by excessive worry, fears, or avoidance
Term
Psychosis
Definition
a serious mental disorder involving loss of contact with reality
Term
Schizophrenia
Definition
chronic psychosis characterized by delusions, hallucinations, disorganized speech and behavior, and lack of emotional response; causes significant interference with social and/or occupational functioning
Term
Mood disorders
Definition
characterized by depressed or manic symptoms
Term
Three types of mood disorder
Definition
Major depression
Manic episodes
Bipolar disorder
Term
In the early twentieth century, many psychotic patients were suffering from __________ _________ of the nervous system (general paresis)
Definition
syphilitic infection
Term
Fever associated with malaria was thought to
Definition
improve the condition
Term
Antibiotics were developed that cured
Definition
syphilis
Term
Narcosis therapy
Definition
depressants used to induce sleep
Term
Intravenous thiopental sodium (“truth serum”) used during
Definition
psychotherapy to help patients express themselves
Term
Electro convulsive therapy
Definition
it was incorrectly believed that inducing convulsions with drugs or electric shocks would cure schizophrenia
Term
Sedatives used in
Definition
severely disturbed patients
Term
Phenothiazines also called
Definition
tranquilizers, neuroleptics, or antipsychotics
Term
Phenothiazines
Definition
Reduce psychotic symptoms without causing sedation
Term
Following introduction of drug therapy, restraints and treatments like convulsive therapy were _______ or ______________ among hospitalized patients
Definition
reduced, discontinued
Term
Treatment with phenothiazines found to be more effective than a
Definition
placebo
Term
Patients relapse when therapy is
Definition
discontinued
Term
Two groups of antipsychotics
Definition
Conventional (introduced before mid-1990s)
Atypical (introduced in the past 10 years)
Term
Antipsychotics produce
Definition
pseudoparkinsonism, indicating a link to dopamine receptors
Term
______ ______ in drug effects indicates that the mechanism of action is probably more complex
Definition
time delay
Term
Atypical antipsychotics block both
Definition
D2 dopamine and 5HT2A serotonin receptors
Term
Atypical antipsychotics produce less
Definition
pseudoparkinsonism
Term
Side effects of anti-psychotics
Definition
Some allergic reactions (jaundice, skin rashes)
Photosensitivity (easily sunburned)
Agranulocytosis (low white blood cell count)
Movement disorders (tremors, muscle rigidity, shuffling walk, masklike face)
Tardive dyskinesia
Term
Even patients experiencing success tend to
Definition
stop taking the drug
Term
Short-term efficacy exists, but long-term appears to be
Definition
considerably lower
Term
No clear evidence that ________ antipsychotics work better than ___________
Definition
atypical, conventional
Term
When used in children there is a high risk of
Definition
weight gain and metabolic changes
Term
Elderly patients with dementia have a significant increase in
Definition
death risk from cardiovascular and other problems.
Term
MAO inhibitors inlcude
Definition
phenelzine, tranylcypromine
Term
Tricyclic antidepressants include
Definition
amitriptyline, doxepin, nortriptyline
Term
SSRIs include
Definition
fluoxetine, sertraline, venlafaxine
Term
MAOs were discovered when
Definition
a drug for tuberculosis was found to also elevate mood
Term
MAOs work by
Definition
increasing the availability of serotonin, norepinephrine, and dopamine
Term
MAO's have limited use because of
Definition
side effects and toxicity
Term
Tricyclic antidepressants were discovered when
Definition
researchers were working to create a better phenothiazine antipsychotic and found a drug that improved mood
Term
Tricyclic antidepressants may work by
Definition
reducing the uptake (and thereby increasing the availability) of norepinephrine, dopamine, and serotonin
Term
Tricyclic antidepressants Not effective in all patients, but they reduce the
Definition
severity and duration of depressive episodes
Term
SSRI's may work by
Definition
reducing the uptake (and thereby increasing the availability) of serotonin
Term
SSRIs are safer than
Definition
tricyclic antidepressants, less likely to lead to overdose deaths
Term
SSRIs are only a little more effective than a
Definition
placebo
Term
SSRIs have strong warning from FDA about
Definition
about an increased risk of suicidal tendencies in children and adolescents
Term
Antidepressants appear to work by
Definition
increasing the availability of norepinephrine or serotonin
Term
A ____ _______ before improvement in mood is seen
Definition
lag period
Term
Most effective treatment for relieving severe depression
Definition
electroconvulsive therapy
Term
Best treatment choice in cases with a risk of suicide
Definition
EC therapy
Term
Lithium: Approved for U.S. sale in
Definition
1970
Term
Early studies found Lithium to be effective in______ patients
Definition
manic
Term
Acceptance of lithium was slow in US because
Definition
Previous history of poisonings
Low perception of seriousness of mania
U.S. drug approval and sale process
Term
Lithium has a high rate of
Definition
patient non-compliance
Term
Lithium
Definition
Normalizes mood in bipolar patients, preventing both mania and depressed mood swings
Term
Other mood stabilizers are
Definition
anticonvulsant drugs
Term
Number of people in mental hospitals ________ dramatically following the introduction of drugs that control the symptoms of schizophrenia to a great degree
Definition
declined
Term
These were set up to treat patients closer to home in a more natural environment at less expense
Definition
Outpatient community mental health programs
Term
Changes for psychiatrists
Definition
Less time spent doing psychotherapy
Priority and emphasis on establishing an appropriate drug regimen
Term
Civil rights issues related to hospitalization
Definition
Indefinite commitment to a hospital is unconstitutional
Periodic review of a patient’s status helps determine if patient presents a danger to self or others
Term
Problems with drug treatment
Definition
Patients may have well-controlled symptoms while on medication in a hospital but may stop taking medication upon release
Unmedicated patients, although not overtly dangerous, may still be too ill to care for themselves
Term
More mentally ill persons are _____ each year than are admitted to state mental hospitals
Definition
jailed
Term
About _____ of all homeless people have some form of serious mental illness
Definition
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