Term
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Definition
| composed of HMWK-Kallikrein, FXII, FXI, FIX, and FVIII |
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Term
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Definition
| composed of trauma, tissue factor (FIII), and FVII |
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Term
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Definition
intrinsic factor
activates XII permanently by proteolysis
involved in "reciprocal autoactivation" |
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Term
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Definition
common pathway
fibrinogen
gets cleaved to fibrin by thrombin |
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Term
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Definition
common pathway
prothrombin
gets cleaved to thrombin by facter Xa |
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Term
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Definition
Extrinsic pathway
tissue factor
binds VII and Ca+ to activate FX |
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Term
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Definition
Both pathways
Ca+
needed to form Kallikrein, FXIa, and FIXa |
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Term
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Definition
Common pathway
proaccelerin
NO CATALYTIC ACTIVITY
serves as cofactor for FXa |
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Term
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Definition
| oddly missing from our clotting cascade |
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Term
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Definition
extrinsic pathway
proconvertin
binds TF and Ca+ to activate FX by proteolysis.
activated by protein-protein interaction* |
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Term
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Definition
intrinsic pathway
antihemophelic factor
combines with FIXa to activate FX by proteolysis |
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Term
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Definition
intrinsic pathway
Christmas factor! (sing: nine platelets clotting)
combines with FVIIIa to activate FX by proteolysis |
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Term
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Definition
point of convergence for extrinsic and intrinsic pathways
Stuart Prower factor
complexes with FVa to cleave prothrombin to thrombin |
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Term
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Definition
intrinsic pathway
thromboplastin antecedant
activates FIX by proteolysis |
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Term
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Definition
intrinsic pathway
Hageman factor
**contact activated!** converts HMWK-prekallikrein to HMWK-Kallikrein
AND
converts HMWK-FXI to HMWK-FXIa |
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Term
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Definition
common pathway
proglutamidase
catalyzes cross-linking of fibrin monomers to retract and form HARD clot |
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Term
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Definition
| inactive enzyme precursor |
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Term
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Definition
| The extrinsic and intrinsic pathways are both needed for proper clotting. True or False? |
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Term
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Definition
| most clotting factors are ____ |
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Term
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Definition
| clotting factors that are stimulatory proteins |
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Term
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Definition
| injury to endothelial lining of blood vessels exposes these |
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Term
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Definition
| this serves as a carrier for FVIII in circulation |
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Term
| factors V,VII,VIII, XIII, and fibrinogen(factor I) |
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Definition
| thrombin activates these five factors in the clotting cascade: |
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Term
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Definition
transmembrane protein of 263 a.a. residues.
domain 1-219 functions as a receptor
domain 220-242 functions as a membrane spanner
cytoplasmic domain 243-263 function is unknown |
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Term
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Definition
| factor X is activated by cleaving off a ____ |
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Term
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Definition
| this terminal of prothrombin contains 10 Gla residues |
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Term
| gamma-carboxyglutamate (Gla) |
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Definition
| has a negative charge and acts as a Ca+ chelator. |
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Term
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Definition
| this cut of prothrombin occurs at an Arg residue in the disulfide bridge |
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Term
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Definition
| prothrombin after the first peptide bond is cleaved. |
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Term
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Definition
MW = 6kD
has no enzymatic activity |
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Term
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Definition
MW = 31kD
acts as a serine protease |
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Term
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Definition
| catalytic triad, common to all serine proteases |
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Term
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Definition
| Thrombin cleaves ___ - ___ bonds in fibrinogen |
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Term
1. stimulates de novo syn. of Gla containing proteins
2. stimulates secretion of these proteins into circulation |
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Definition
| N-terminal Gla containing peptides get removed by the liver. This triggers two things: |
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Term
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Definition
| these factors require Ca+ |
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Term
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Definition
Length = 460A
Period = 230A
half staggered array in soft clot |
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Term
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Definition
| this is unique to fibrinogen and NOT found in fibrin |
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Term
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Definition
| these are rich in the acidic residues: Asp, Glu, and tyrosine-O-sulfate |
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Term
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Definition
| when soft clots are converted to hard by FXIII (transglutamidase), these bonds are formed |
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Term
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Definition
| serves as redox cofactor for carboxylase that catalyzes formation of Gla residues in blood clotting factors II,VII,IX, and X as well as proteins C and S. |
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Term
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Definition
| these factors are bound to their phospholipid activation sites by Ca + |
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Term
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Definition
| the most reduced form of vit. K |
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Term
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Definition
| most oxidized form of vit. K |
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Term
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Definition
this dithiol dependent enzyme catalyzes:
vit. K epoxide + R1H2--> R1 + vit. K (quinone) |
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Term
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Definition
this enzyme catalyzes:
Vit. K + R2H2 --> R2 + Vit. KH2 |
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Term
| Vit. K dependent carboxylase |
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Definition
this enzyme catalyzes:
Vit. KH2 + O2 + prozymogen (Glu) + CO2 --->
carboxylated prozymogen (Gla) + Vit. K epoxide + H2O |
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Term
| Warfarin (coumadin) and dicoumarol |
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Definition
| these Vit. K analogs inhibit vit. K epoxide reductase and Vit. K reductase. |
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Term
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Definition
| protein C and S are activated by Thrombin, and they inactivate Factor Va and VIIIa by proteolysis on ___ residues |
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Term
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Definition
| a serine protease inhibitor, such as antithrombin III |
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Term
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Definition
| binds thrombin to inhibit clotting |
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Term
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Definition
| this compound facilitates inhibition of coagulation by 9,000x for FIIa and 17,000x for factor Xa. |
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Term
| LACI = TFPI =anticonvertin |
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Definition
| lipoprotein-associated coagulation inhibitor, tissue factor pathway inhibitor, binds to TF-FVIIa-Ca+-Xa complex. inhibits factors VIIa and Xa. |
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Term
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Definition
| potent stimulants for platelet aggregation. reciprocally autoactivated. |
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Term
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Definition
| inhibits platelet aggregation when no injury is present. |
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Term
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Definition
| binds to heparin, and sequesters it in order to promote clot formation |
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Term
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Definition
| released by platelets to cause vasoconstriction during injury. |
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Term
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Definition
| stimulates repair of injured tissues |
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Term
1. adhesion and aggregation
2. phospholipid surface for binding of clotting factors |
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Definition
| the two major roles of platelets (thrombocytes) |
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Term
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Definition
| platelets adhere to subendothelial ______ at injury site. |
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Term
| endothelial cells and megakaryocytes |
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Definition
| vWf gets synthesized by these cells |
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Term
1. GP Ib/IX
2. GP IIb/IIIa |
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Definition
| vWf binds to these two receptors during formation of the "plug" |
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Term
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Definition
| bleeding tendency with deficiency of GP Ib/IX |
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Term
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Definition
| bleeding tendency with deficiency of GP IIb/IIIa |
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Term
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Definition
| bleeding tendency with deficiency of vWf |
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Term
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Definition
| fibrinolysis occurs through the action of this compound |
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