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Skeletal Muscle is a ____ Muscle and is controlled ____ |
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How many skeletal muscle muscles are there throughout the body |
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Long axis of a muscle determines |
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extensor digitorum longus |
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Fiber arrangement influences |
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Force generating capacity Physiological cross section |
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surrounds several fibers and forms bundles called Fasciculi |
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Surrounds all the bundles to form the entire muscle |
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myogenic stem cells located within the sarcolemma |
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regenerate cell growth play a role in hypertrophy |
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Sarcoplasmic reitculum is an |
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extensive lattice-like network of tubules and vesicles that provides structural integrity Stores, releases, and reabsorbs CA2+ |
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Chemical composition of skeletal muscle |
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75% water 20% protein 5% salts, phosphates, ions, and macronutrients |
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expedites removal of metabolic by-products increases O2 delivery |
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Tropomyosin is distributed |
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the entire length of the actin filament |
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the interaction of actin and myosin |
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actin filament, it is the calcium receptive protein |
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troponin keeps myosin from |
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hexagonal pattern around myosin |
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around the myosin where actin and myosin overlap |
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actin in the groove formed by the double helix |
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regular intervals along actin |
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CA2+ and moves tropomyosin, revealing cross-bridge binding sites |
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The sarcoplasmic reticulum is distributed around |
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the myofibrils such that each sarcomere has 2 triads |
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In the sliding filament model, contraction occurs as |
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myosin and actin slide past one another |
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Myosin cross-bridges cyclically |
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attatch, rotate, and detatch from actin filaments |
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Energy for the sliding filament model is provided by |
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Myosin cross-bridges contain |
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bends around ATP molecule and becomes cocked |
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functional aspect of muscle control |
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The motor end plate is the point where |
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the nerve innervates the muscle fiber |
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Muscle action is initiated by |
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ACh which allows sodium to enter and depolarize the cell |
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If the cell is sufficiently depolarized, |
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an action potential occurs which releases stored CA2+ |
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troponin, which lifts the tropomyosin molecules off the active sites on the actin filament |
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Once myosin binds with actin, |
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the myosin head tilts and pulls the actin filament so they slide across each other |
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calcium is pumped out of the sarcoplasm to the SR for storage. CA2+ is actively pumped into SR |
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For a motor unit to be recruited into activity the motor nerve impulse |
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must meet or exceed the threshold |
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When the motor nerve impulse meets or exceeds threshold, |
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all muscle fibers in the motor unit act maximally |
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If the motor nerve impulse threshold is not met |
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no fibers in that unit act |
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high capacity to Transmit AP High myosin-ATPase activity Rapid release and reuptake of Ca2+ by SR High rate of cross-bridge turnover Capable of high force generation Rely on anaerobic metabolism |
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Fast shortening speed Fast contractile speed High SR development Moderately well-developed capacity for both anaerobic and aerobic energy production 300-800 fibers per motor neuron |
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most rapid shortening velocity fast contractile speed high SR devlopment Rely on anaerobic energy production Low aerobic capacity 300-800 fibers per motor neruon |
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high aerobic capacity and fatigue resistance low anaerobic capacity and motor unit strength slow contractile speed 10-180 fibers per neuron low SR development Slower Ca2+ release and reuptake by SR Large number of mitochondria |
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