Term
| Recommended initial Regimen in Most people with HIV |
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Definition
| INSTI (Integrase Strand Transfer Inhibitors) |
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Term
| Lovastatin and Simvastatin Contraindicated in.. |
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Definition
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Term
| Tivicay (Dolutegravir) increases >>>> |
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Definition
| METFORMIN Concentrations (dont exceed 1000mg Metformin) OCT2 intrxn (Dofetilide too) |
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Term
| INSTIs and antacids Counseling |
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Definition
-Dolutegravir:Take 2 hrs before or 6 hrs after antacid
-Elvitegravir/Bictegravir: Separate antacids by 2hrs |
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Term
| Don't use Raltegravir with |
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Definition
| Aluminum or MgOH antacids or once daily dosing w/ CaCO3 -if bid no sep needed with CaCO3 |
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Term
|
Definition
Take INSTIs 2 hrs before or 6 hrs after
-Calcium and iron with DTG/BIC ok with food |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
-Neuro effects****
-False positive drug tests for Marijuana or BZDs
-Teratogenic
-Rash
-Vivid Dreams |
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Term
|
Definition
GG=Inc Clearance, Dec conc
TT(GT too)=Dec Clearance, Inc conc |
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Term
|
Definition
Contraindicated
(Needs acidic pH) |
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Term
|
Definition
SFX:SJS,TENS,DRESS
Immune mediated hepatotoxicity |
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Term
| Contraindicated with Strong inducers (Rifampin) |
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Definition
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Term
|
Definition
Renal Disease
avoid nephrotoxic co-administration |
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Term
|
Definition
Dyslipidemia
Hyperglycemia
Gi intolerance
Lipohypertrophy |
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Term
|
Definition
Lipohypertrophy Crix Belly
Nephrolithiasis
Jaundice |
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Term
|
Definition
| Dont exceed 10mg Rosuvastatin |
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Term
|
Definition
| Dont exceed 20mg Atorvastatin |
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Term
| PIs and Simvastatin and Lovastatin |
|
Definition
CONTRAINDICATED
(PRAVASTATIN:use lowest dose possible) |
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Term
|
Definition
Ok with PIs
(Use smallest dose first with Atazanavir) |
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Term
| DO NOT administer ATAZANAVIR with |
|
Definition
PPI if UNBOOSTED
-Give PPi 12 hrs before boosted ATZNVR (max 20mg omeprazole) |
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Term
|
Definition
| Stavudine
Zidovudine
(dont administer them together!)< |
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Term
|
Definition
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Term
| Which Analog is Life threatening if administered with same class |
|
Definition
THYMIDINE ANALOGS
(dont administer together) |
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Term
|
Definition
LIPOATROPHY
Neuropathy
Myopathy
Lactic acidosis
Cardiomyopathy |
|
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Term
|
Definition
Adjust all NRTIs
(except abacavir) |
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Term
|
Definition
| Lactic acidosis & hepatomegaly w/ steatosis |
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Term
| Prolonged NRTI exposure causes |
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Definition
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Term
| Worst offenders for LIpoatrophy |
|
Definition
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|
Term
| Nail Hyperpigmentation with??? |
|
Definition
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Term
| Maraviroc only effective against |
|
Definition
|
|
Term
| FUZEON(Enfuvirtide) Administered how? |
|
Definition
SubQ
BID
-45 mins to reconstitute |
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Term
| TROGARZO (Ibalizumab) Administered how? |
|
Definition
IV only
-for multidrug resistant HIV-1 |
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Term
| HIV Barriers to adherence |
|
Definition
Age (<25yrs or >65 yrs)
Time since Tx initiation
IVDU
Pill Burden
Adverse events
Psych illness |
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Term
| JULUCA/ dual therapy used for |
|
Definition
Virally suppressed Pts
(<50copies/mL)
-Viral load undetectable for at least 6 months |
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Term
|
Definition
| Nevirapine or Raltegravir |
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Term
| HIV regimen >14 days-3yrs old |
|
Definition
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Term
| HIV regimen >/=3yrs to 6 yrs |
|
Definition
Raltegravir OR Atazanavir
OR Darunavir |
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Term
| HIV regimen >/=6yrs to 12 years old |
|
Definition
Dolutegravir (wgt >/=30kg)
OR
Atazanavir |
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Term
| HIV regimen>/=12yrs old (SMR I-III) |
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Definition
>/= 30 kg:Dolutegravir
>/= 35 kg:Elvitegravir/Cobicistat
>/= 40 kg:Atazanavir OR Darunavir |
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Term
VL >1000mg copies/mL in pregnant woman use
(Labor and Delivery) |
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Definition
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Term
|
Definition
6-12 hrs after birth use IV Zidovudine for 4 weeks
(high risk =6wks) |
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Term
| Virologic testing when for infants with known perinatal HIV exposure |
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Definition
Baseline
2-3 wks
1-2 months AND 4-6 months |
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Term
| If less than 3 yrs old and considering Efavirenz youll need.... |
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Definition
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Term
| HIV and elderly comorbidities |
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Definition
CV Disease
Dyslipidemia
Diabetes
Renal Dysfunc |
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Term
| _____increases Buprenorphine concentrations |
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Definition
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Term
|
Definition
ARVs cause Methadone concentration to decrease.
(Increase methadone Dose if using ARV) |
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Term
|
Definition
#1: BIKTARVY
#2: Triumeq
#3: Dolutegravir + Truvada
#4: Raltegravir + Truvada |
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Term
| If the patient is taking a CYP3A4 inducer, how do you dose Dolutegravir? |
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Definition
|
|
Term
| When do you use once daily dosing of Dolutegravir? |
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Definition
| When there is NO resistance |
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