Term
|
Definition
NRTI
ADE: Hypersensitivity rxn
Black box for lactic acidosis and hepatic steatosis |
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Term
|
Definition
NRTI
ADE: Pancreatitis, peripheral neuropathy, N/V/D
Black box for lactic acidosis and hepatic steatosis |
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Term
|
Definition
NRTI
ADE: Hep-B exacerbation
Black box for lactic acidosis and hepatic steatosis |
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Term
|
Definition
NRTI
ADE: Hep-B exacerbation
Black box for lactic acidosis and hepatic steatosis |
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Term
|
Definition
NRTI
ADE:Peripheral neuropathy, lipodystrophy, pancreatitis, hyperlipidemia
Black box for lactic acidosis and hepatic steatosis |
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Term
|
Definition
NRTI
ADE: Renal insufficiency, HA/N/D, Hep-B exacerbation
Black box for lactic acidosis and hepatic steatosis |
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Term
|
Definition
NRTI
ADE: Bone marrow suppression, macrocytic anemia or neutropenia, GI upset
Black box for lactic acidosis and hepatic steatosis |
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Term
|
Definition
NNRTI
ADE: Rash, CNS symptoms, increased transaminase levels, pregnancy category C
Black box warning for both hepatotoxicty and rash |
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Term
|
Definition
NNRTI
ADE: Rash, N/HA
Black box warning for both hepatotoxicty and rash |
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Term
|
Definition
NNRTI
ADE: Stevens-Johnson Syndrome, most likely NNRTI to cause hepatotoxicity
Black box warning for both hepatotoxicty and rash |
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Term
|
Definition
PI
ADE: Indirect hyperbilirubinemia, diarrhea
Class ADEs:(N/V/D), Liver enzyme elevations, Hyperlipidemia, Hyperglycemia, Lipodystrophy (fat redistribution)
Does NOT cause metabolic complications unlike other PIs. |
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|
Term
|
Definition
PI
ADE: Rash, D/N/V/HA
Class ADEs:(N/V/D), Liver enzyme elevations, Metabolic complications,
Hyperlipidemia, Hyperglycemia,
Lipodystrophy (fat redistribution) |
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|
Term
|
Definition
PI
Class ADEs:(N/V/D), Liver enzyme elevations, Metabolic complications,
Hyperlipidemia, Hyperglycemia,
Lipodystrophy (fat redistribution) |
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Term
|
Definition
PI
ADE: Nephrolithiasis, hyperbilirubinemia
Class ADEs:(N/V/D), Liver enzyme elevations, Metabolic complications,
Hyperlipidemia, Hyperglycemia,
Lipodystrophy (fat redistribution) |
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Term
|
Definition
PI
ADE: Taste perversion
Class ADEs:(N/V/D), Liver enzyme elevations, Metabolic complications,
Hyperlipidemia, Hyperglycemia,
Lipodystrophy (fat redistribution) |
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|
Term
|
Definition
PI
Class ADEs:(N/V/D), Liver enzyme elevations, Metabolic complications,
Hyperlipidemia, Hyperglycemia,
Lipodystrophy (fat redistribution) |
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|
Term
|
Definition
PI
ADE: Hepatotoxicity, intracranial hemorrhage (Black box)
Class ADEs:(N/V/D), Liver enzyme elevations, Metabolic complications,
Hyperlipidemia, Hyperglycemia,
Lipodystrophy (fat redistribution) |
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|
Term
|
Definition
EI
ADE: Injection site rxns (pain, nodules, etc.), Increase rate of bacterial pneumonia |
|
|
Term
|
Definition
EI
ADE: N/V/D, sore throat, elevated LFTs, possible increase in malignancy |
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Term
|
Definition
II
ADE: N/V/S, Creatinine kinase elevations (myopathy and rhabdomyolysis have been reported) |
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|
Term
| Preferred treatment for pregnancy: |
|
Definition
| Kaletra + Combivir taken BID |
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|
Term
| Preferred HIV treatment with no contraindications |
|
Definition
NNRTI + 2NRTI
Atripla 1T PO QD HS |
|
|
Term
| Integrase Inhibitor Regimen |
|
Definition
|
|
Term
|
Definition
| Tenofovir + Emtricitabine |
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|
Term
|
Definition
|
|
Term
|
Definition
| Abacavir + Lamivudine + Zidovudine |
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|
Term
|
Definition
|
|
Term
|
Definition
| Emtricitabine + Tenofovir + Efavirenz |
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|
Term
|
Definition
| Emtricitabine + Tenofovir + Rilpivrine |
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Term
|
Definition
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Term
|
Definition
Bind directly to reverse transcriptase and inhibit its action.
Blocks DNA polymerization. |
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Term
|
Definition
Bind within active pocket of protease, inhibiting the binding of the virus.
Without protease cleavage, the virus is unable to cause an infection. |
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Term
|
Definition
| Compete with viral nucleotides for incorporation into viral DNA chain. Next incoming nucleotide is unable to form a phosphodiester bond due to absence of 3' hydroxyl group on NRTI. Results in chain termination of viral DNA. |
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Term
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Definition
Fusion/Entry Inhibitor
Binds to gp41 |
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Term
|
Definition
Fusion/Entry Inhibitor
CCR5 co-receptor inhibitor.
Prevents entry of virus into the cell |
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