Term
| what is the prodrug of acyclovir |
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Definition
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Term
| this HIV drug class causes adverse events of central obesity, dorsocervical fat enlargement (buffalo hump), facial wasting |
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Definition
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Term
| what class does efavirenz and nevirapine fall into |
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Definition
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Term
| what inhibits uncoating of influenze A and is 100% cross-resistant to rimantadine |
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Definition
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Term
| what group of HIV drugs are inhitors of transcription and can cause flu like symptoms and depression |
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Definition
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Term
| what is a drug that can be used to treat Hep B and C |
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Definition
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Term
| what are the endings that are associated with HIV drugs that inhibit RNA/DNA replication |
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Definition
| -vir,-virin, -dine, and -bine |
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Term
| what is the prodrug of penciclovir that is used to treat oral herpes |
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Definition
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Term
| nonnucleoside; directly inhibits DNA Pol by preventing cleavagge of pyrophosphate from nucleoside triphosphate. Used with ganciclovir to treat CMV retinitis. Can produce significant nephrotoxicity. |
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Definition
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Term
| cytidine analog converted by host cellular enzymes to active diphosphate anabolite; only IV aministration, treats CMV, dose dependent nephrotoxicity, administered with probenecid |
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Definition
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Term
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Definition
| used to treat HBV, phosphorylated to active triphosphate form |
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Term
| ___ is a guanosine analog that can be used against influenze and RSV (in children); toxicities are hematologic following PO and teratogenic potential |
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Definition
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Term
| what drug is used to treat CMV and works through antisense mechanism |
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Definition
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Term
| what is a nucleoside analog of adenosine activated by cellular kinases that is used to topically to treat HSV keratitis, keratoconjunctivitis |
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Definition
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Term
| what are trifluridine and idoxuridine used for |
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Definition
| two opthalmic drugs used topically to treat HSV keratitis; both act as thymidine analog to block viral DNA replication |
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Term
| what drug used to treat CMV in immunocompromised patients is a guanosine analog, poorly absorbed, and causes bone marrow toxicity |
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Definition
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Term
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Definition
| treat HIV and HBV; cross resistance with lamivudine, nucleoside analog |
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Term
| used to treat chronic HBV, effective against lamivudine (3TC) resistant strains, cuases nephrotoxicity |
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Definition
| adeofovir dipivoxil (Hepsera) |
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Term
| necleoside analog used to treat chronic HBV; less effective against lamivudine resistant HBV |
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Definition
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Term
zanamavir and oseltamivir are used in combo to treat : A: Influenza A only B: Influenza A and B C: neither |
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Definition
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Term
| What is Raltegravir used for |
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Definition
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Term
| T or F Trifluridine, cidofovir, and foscarnet require viral thymidine kinase to phosphorylate them |
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Definition
| False the only require host enzymes |
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Term
| T or F Acyclovir is primarily used to treat patients with ebstein-Barr virus |
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Definition
| False- primarily used to treat herpes |
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Term
| T or F Acyclovir is primarily used to treat patients with ebstein-Barr virus |
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Definition
| False- primarily used to treat herpes |
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Term
| what are Cidofovir, Ganciclovir, valganciclovir, Foscarnet, and Fomiveirsen all first line treatmetns for? |
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Definition
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Term
| lactic acidosis, steatoisis, myositis, myopathy, hepatomegaly, mitochondrial toxicity, and lipodystorophy are characteristic adverse affects of which class? |
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Definition
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Term
| T or F NNRTIs compete with nucleoside triphosphate and require phosphorylation to be active? |
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Definition
| False - they do not require phosphorylation to be active and d not compete |
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Term
| rash, drug interactions, and CNS involvement (hallucinations, abnormal thinking, confusion, etc) are common adverse events with NRTIs or NNRTIs |
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Definition
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Term
| How does raltegravir inhibit HIV |
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Definition
| It blocks HIV inegration into host DNA |
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Term
| T or F protease inhibitors are stimulators of the CYP450 |
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Definition
| Flase they are inhibitors |
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