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1590 - principle of a microscope |
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1680 - dutch merchant...described "animalcules" |
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1680 - Attacked the concept abiogenesis (spontanious generation) (macro) |
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1750 - set back the concept of "omne vivum ex vivo" (all life comes from life) |
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1776 - Hermetically sealed flasks excluded oxygen ("vital force") |
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1836 - use of acids and bases |
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1850-1875 - Disproved abiogenesis (micro), proved microorganisms as causative agents in putrefaction (spoilage) and fermentation |
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1850-1875 - Established isolation techniques, proved the nature of a specific organism for specific disease (Henle's postulates), proved germ theory |
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1928 (1945) - Discovered Penicillin |
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1936 - crystallized a virus |
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1942 - "One gene, One enzyme" |
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1943 - Practical Application of electron microscopy |
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1944 - Molecular genetics, DNA = heredity |
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Watson & Crick (compare to Einstien) |
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1955 - Double helix (DNA structure) |
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1960 - Immuno-chemistry, elucidation of antibody molecules |
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1968 - systhesized a polypeptide |
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1970 - synthesized a gene |
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functional aspects of a recombinant gene, isolation of restriction endonucleases |
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1975 - Identification of reverse transcriptase |
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1976 - rapid sequencing of bases in synthetic DNA production |
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1977 - synthesis of useful non-bacterial protiens (insulin &interferon) by bacteria |
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1983 - Marketing of human insulin based on recombinant DNA, biotechnology market |
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1987 - Genetic principle of antibody diversity |
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1989 - Genetic basis of cancer |
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1990 - first approved gene theropy experiment |
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Human genome project results, genomics, proteomics |
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