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histology
male reproductive system
27
Medical
Graduate
10/07/2008

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Term
seminiferous tubules
Definition
site of sperm production 1-4 per lobule
Term
seminiferous epithelium
Definition
proliferating population of germ cells in various levels of differntiation and non-germ-line cells that support the germ cells, Sertoli cells.
Term
spermatogonia
Definition
lie adjacent to plasma membrane, as differentiation proceeds they move toward lumen. type A stem cells that divide mitotically. Give rise to more stem cells. Type B are progenator cells which undergo mitosis and produce primary spermatocytes.
Term
Primary spermatocytes
Definition
closer to lumen than spermatogonia look like secondary spermatocytes. first meiotic prophase takes about 16 days. These are seen a lot. They are 4n with 46 pairs of sister chromatids.
Term
secondary spermatocytes
Definition
smaller, divide (meiosis 2) quickly to produce spermatids. Have a 2n compliment with 23 pairs of sister chromatids before meiosis 2.
Term
spermatids
Definition
differentiating 1n, 22+1 x or Y.
Term
intercellular bridges
Definition
present between germ cells. incomplete cytokinesis. may allow for synchronization of sperm development
Term
Spermatogenesis
Definition
spermatogonia are transformed into mature sperm. Three phases: stem cell renewal, meiosis, and spermiogenesis.
Term
Spermiogenesis
Definition
morphological transformation of spermatid to to spermatozoan. Acrosomal formation from Golgi apparatus, nucleus condensation, flagellum formed in centriole, and cytoplasm and organelles are shed to be eaten by sertoli cells.
Term
spermatogenesis
Definition
takes 64 days
Term
sertoli cells
Definition
extend from membrane to lumen.large basally located nucleus just above level of spermatagonia. Prominent nucleolus. tight junctions divide seminiforous epi into basal and adluminal components. form blood-testis barrier. Spermatogonia lie on blood side of barrier, not protected from antibodies. produce ABP. Increases local testerone.
Term
sertoli cells 2
Definition
phagocytize, nourish germ cells, secrete fluids into lume, stimulated by FSH and testosterone. Produce inhibin and activin, activate and depress FSH feedback process.
Term
lamina propria
Definition
myoid contractile cells, fibroblasts and collagen bundles. contraction of myoid cells propels contents of tubules toward rete testis.
Term
interstitial tissue
Definition
LCT- leydig cells, nerves, lymphatics, blood vessels, macrophages.
Term
Leydig Cells
Definition
secrete testosterone, found in groups. polygonal. mitchondria have tubular cristae. Contain cytoplasmic crystale of reinke. under the influence of LH (ICSH)
Term
FSH
Definition
stimulates sertoli cells to produce ABH, required for testis development in developing males.
Term
Testosterone
Definition
libido, spermatogenesis, structural and functional maintenance of male accessory characteristics.
Term
Tubuli recti
Definition
straight seminiferous tubules. No germ cells near junction. Only sertoli cells that merge and become simple cuboidal epithelium that lines tubuli recti.
Term
Rete testis
Definition
simple cuboidal or columnar epithelium and has short microvilli and a single flagellum.
Term
ductuli efferentes
Definition
collecting duct for rete. connect to epididymis. coiled, cone-shaped mass in the head of the epididymis. Festooned epithelium (cuboidal alternating with columnar. some ciliated, some only microvilli resorb most of fluid secreted by the seminiferous epithelium. muscular circular layer that thickens b epididymis.
Term
Epididymis
Definition
4-6 meters, site of sperm competence. Pseudostratified columnar. Low basal cells and tall columnar cells with stereocilia (greatly elongated microvilli, contain actin filaments, not microtubules). fluid resorption. Shorter in tail of epididymis. Defined basement membrane and thin LP. Outer layer of circular muscle that thickens as it approaches the ductus deferens. Sperm are compacted into dense mass. Serves as sperm reservoir. Contracts with nervous stimulation to expel sperm. androgen-dependent sperm maturation. passive transport due to fluid movement. helped with cilia and flagella and smooth muscle peristalsis.
Term
Ductus deferens
Definition
epi to prostatic urethra. passes up spermatic cord, out of scrotum, into abdominal cavity and joins the urethra. three layers, Mucosa- stereocilia, low psuedostratified columnar epithelium, similar to tail of epididymis. lots of elastic fibers in lamina propria. Muscularis: thick coat: inner and outer longitudinal layer and thick inner circular layer.
Term
Ductus deferens
Definition
nervous stimulation causes contractions of thick muscle - main propulsive force for ejaculation.
Term
Ampulla
Definition
part of ductus deferens in abdominal cavity. high mucosal folds branched. Just before ductus deferens connects to seminal vesicles to form the ejaculatory duct.
Term
seminal vesicles
Definition
appears artificially to have chambers due to extensive branching. elastin rich lamina propria, inner circular and outer longitudinal layer. of smooth muscle. yellowish, viscous secretion containing many reducing substances. High in fructose to feed spermies. and ascorbic citric acid. Prostiglandins.
Term
Prostate
Definition
30-50 tubuloalveolar glands around and emptying into urethra. Periurethral glands (separated from true urethra by smooth muscle). Submucosal glands in middle layer. Main prostatic glands are peripherally located. Cancer in true prostate or peripheral zone. in a fibro-muscular matrix- contraction expels this stuff. colorless (pH 6.5), enzymes, zinv, citric acid, and acid phosphatase. Concretions in older men. Cause distension of the gland. needs testosterone.
Term
bulbourethral glands
Definition
Cowper's glands- peasized tubuloalveolar glands empty into urethra via looong ducts. clear, viscous containing sialoproteins, ma serve as lubricant for spermies during ejaculation!
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