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Histology Exam 1
Lecture 7 (Connective Tissue)
34
Other
Not Applicable
06/06/2008

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Term
function of connective tissue
Definition
- transport nutrients, o2, waste and metabolites
- immunological surveillance/defense
- mechanical support
- growth and repair
- energy storage and thermoregulation
- hematopoiesis
Term
composition of CT
Definition
- cells
- extracellular matrix
Term
cells of CT
Definition
- fibroblasts
- macrophages
- mast cells
- plasma cells
- adipocytes
Term
fibroblasts
Definition
- secrete all components of extracellular matrix
- repairs and regenerates CT following damage
Term
macrophages
Definition
- engulf/destroy bacteria through phagocytosis
- remove necrotic debris
- participate in immune and inflammatory response
- number increases in CT following wound/inflammation
Term
mast cells
Definition
- participate in allergic reaction
- release histamine and heparin after allergen binding
- central role in asthma, eczema, itch, allergic rhinitis and allergic conjunctivitis
Term
histamine vs. heparin
Definition
- vasodilator
- anticoagulant
- both proteins
Term
plasma cells
Definition
- synthesize/secrete abys
- function in immune response to destroy bacteria and other antigens
Term
adipocytes
Definition
- unilocular
- stores fat/lipids
- incorporate into loose CT to form fat
Term
extracellular matrix
Definition
- fibers
- ground substance
Term
fibers in Extracellular Matrix
Definition
- collagen
- elastic fibers
Term
collagen
Definition
- major insoluble protein in CT
- most abundant protein in body
- fibrillar and basement membrane
- types I-IV
Term
fibrillar collagen
Definition
- provides tissues with tensile strength
- types I-III
Term
type I collagen
Definition
- fibrillar collagen
- all CT in oral cavity except enamel
- Sharpey's fibers
Term
sharpey's fibers
Definition
- type I collagen
- bundles of fibrillar collagens inserted into surface of mineralized tissues (bone/cementum)
- attached to periosteum and periodontal ligament
Term
type II
Definition
- fibrillar collagen
- in cartilage
Term
type III
Definition
- fibrillar collagen
- forms reticular fibers
Term
basement membrane collagens
Definition
- type IV collagen
Term
elastic fibers
Definition
- allow tissues to go back to normal shape after stretching/distortion
- consist of microfilaments and elastin
Term
ground substance
Definition
- protein and sugar (glycoamino- and proteo- glycans)
- glycoproteins
- water
Term
mesenchyme
Definition
- most abundant CT in embryo
- very little in adult
- closest related to tooth pulp in adult
Term
adult connective tissue
Definition
- loose
- adipose
- reticular
- dense irregular
- dense regular
- cartilage
- elastic
- bone
Term
loose CT
Definition
- located directly under epithelium w/basal lamina in between
- lots of cells, blood vessels, nerves and glands
Term
lamina propria
Definition
- loose connective tissue in GI tract and oral cavity
Term
adipose CT
Definition
- storage of energy in form of lipids
- insulates against heat loss
- space filler btwn organs or tissue layers of organs
- cushioning soles of feet, orbits of eyes, and around kidneys
Term
reticular CT
Definition
- consists of reticular fiber network
- made of collagen type II
- provides delicate structural support
- found under basal lamina, around blood vessels and nerves and in lymph organs
Term
dense irregular
Definition
- lost of large collagen fibers running in all directions
- few cells
- great tensile strength
- forms capsules around organs
Term
dense regular
Definition
- ordered arrangement of collagen type I fibers and fibroblasts
- mainly in tendons and ligaments
- great tensile strength in direction of fibers
Term
cartilage
Definition
- firm, non-calcified CT
- shock-absorbing, sliding area for joints
- facilitates bone movement
- development/growth of long bones
- not vascularized or innervated
- contain chondrocytes
Term
chondrocytes
Definition
- mitotic cells allowing growth
- can multiply and secrete cartilage matrix
- slows in adults and eventually die to create calcification of the cartilage
Term
hyaline cartilage
Definition
- most widely distributed in embryo/adult
- collagen type II fibers
- forms fetal skeleton
- epiphyseal plates
- articular cartilage covers articular surfaces of adult bone
Term
elastic cartilage
Definition
- collagen type II fibers and elastic fibers
- found in areas that need to bend or recoil
- external ears and epiglottis
Term
fibrocartilage
Definition
- areas subject to both compression and tension
- combo of cartilage and collagen type II
- type I runs btwn chondrocytes of cartilage
Term
elastic CT
Definition
- type I collagen fibers and lots of elastic fibers
- allow organs to stretch in several directions then recoil
- found in aorta
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