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- RBCs/erythrocytes - Platelets - WBCs/Leukocytes - Plasma |
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- volume of packed RBCs per unit volume of whole blood |
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- layer of leukocytes and platelets |
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- liquid obtained when whole blood is centrifuged in the presence of anticoagulants (heparin) - no cells - protein |
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- plasma without fibrinogen - obtained by collecting blood and allowing it to clot - no cells/blood clotting proteins |
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- biconcave shape - main function is O2 and CO2 transport and exchange btwn tissues |
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- provide high surface area to volume ratio in RBCs |
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- shape maintained by cytoskeleton - deformable - able to squeeze through gaps in endothelial cells - live <4 months - removed by spleen, liver and bone marrow |
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- most active site for removal of aged RBCs |
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- non-nucleated - "formed elements" - derived from megakaryocyte - circulate 7-14 days in blood - function in hemostasis |
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- form platelets/thrombocytes |
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- true cell contain organelles and nucleus - produced in red bone marrow - travel in blood, but can migrate to CT |
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- neutrophil - eosinophil - basophil - lymphocyte - monocyte |
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- neutrophils - lymphocytes - monocytes - eosinophils - basophils |
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- leukocytes from most to least |
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- agranulocytes - 2nd most abundant - t-cells and b-cells |
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- become plasma cells that function in CT/synthesize abys |
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- function in cell mediated IR detsroying foreign/infected cells - do not make abys |
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- agranulocyte - largest WBC - differentiate into macrophages in CT - remove foreign particles |
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- granulocyte - aka PMN - most numerous WBC in normal blood - migrates to areas of tissue damage and phagocytose bacteria/debris/dead cells |
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PolyMorphoNuclear neutrophilic leukocytes aka Neutrophils |
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- granulocyte - increases in number if combating allergen, parasitic infection, chronic inflammation, and bronchial asthma |
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Conditions leading to increased eosinophil count |
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- allergen, parasitic infection, chronic inflammation, and bronchial asthma |
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- least common WBC - granulocytes - function similar to mast cell - granules contain molecules affecting allergen response |
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- contain histamine and heparin |
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- hydrophilic vasoactive amine - increases permability of small bv causing edema and itching - increases mucous production and smooth muscle contraction in lung |
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