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aggregated chromatin- nuclei inactive- dark stain fibroblast |
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Transcriptionally active- nuclei active- light stain fibrocyte |
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nuclear envelope nuclear matrix nucleolus chromatin |
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new growth- malignant/benign - TUMOR |
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2 parallel unit membranes around perinuclear cisterna
inner layer= lamins a, b, c - breakdown when cell in division-phosphorylation of lamina by lamin kinase during prophase mitosis initiate nuclear disassembly into small vesicle
outer layer- ribosomes attached- continuous with RER- sythesized proteins temp stored in perinuclear cisterna |
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in nuclear envelope- where inner/outer layers fuse together
form circ gaps - 3 parts each with 8 subunits
cytoplasmic ring- Protein transport mucleoplasmic ring- form nuclear basket with fibers extended in nucleoplasmic margin- RNA transport
middle ring- interposed between the two
receptor mediated transport- naterials have nuclear localization segments recognized by NPC: requires exporin/imporin proteins **regulated by G protein- Ran |
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basophilic- responsible for RNA sythesis
dispersed/peripheral/nucleolus
condense for division- composed of 2 coiled DNA strans- 2 proteins/histones/nonhistones (reg DNA function)
Solenoid- 6 nucleosomes around axis |
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in females- one X chromosome is inactive- heterochromatic
Barr body- planoconvex mass on peripherary of inner surf nuclear membrane
drumstick- white blood cells nucleolar satellite-neurons (mass round nucleolus) |
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long- double strand deoxyribose sugar, phosphate,base (pyrimidine ct purine ag) h bonds between base pairs |
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dna regions - segments- code special region |
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between exons- no code for RNA |
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3 base sequence for single aa code |
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total genetic complement of individual in chromosome
number/characteristics of individ chromosomes |
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round- basophilic- rich in RNA/protein
disappear in cell division- imp in rRNA synthesis
pars granulosa contain precursor granules of RS
pars fibrosa contain fine filament- precursor of rRNA
nucleolar organizer regions- transcript RNA |
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amorphous- same chem as cytoplasm
ribonucleioproteins particles nucleoskeleton- continuous fibrillar structure |
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replicate 1- divide 2
prophase of M1: leptotene, zygotene, pachytene, diplotene, DIAKINESIS- dna segment crossover occurs |
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Klinefelter- 47xxy turner - 46 xo down (trisomy #21) - 3 #21 chromosomes |
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