Term
5HT-3 antagonist used in chemotherapeutic induced
emesis |
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Definition
Aprepitant, Ondansetron, granisetron,
dolasetron and palonosetron |
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Term
| 5HT-1D/1B agonist used for migraine headaches |
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Definition
| Sumatriptan, naratriptan, and rizatriptan |
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Term
| 1st generation antihistamine that is highly sedating |
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Definition
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Term
| ACTH analog used for diagnosis of patients with corticosteroid abnormality |
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Definition
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Term
| Agents for reduction of postpartum bleeding |
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Definition
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Term
| Agents used in treatment of carcinoid tumor |
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Definition
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Term
| Antidote for tissue plasminogen activator (t-PA), streptokinase |
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Definition
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Term
| Antidote used for heparin toxicity |
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Definition
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Term
| Antidote used for organophosphate/anticholinesterase poisoning |
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Definition
| Atropine, pralidoxime (2-PAM) |
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Term
| Anti-estrogen used for estrogen receptor + breast cancer |
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Definition
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Term
| Binds tubulin and prevents the disassembly of microtubules during the M phase of the cell cycle inducing mitotic arrest |
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Definition
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Term
| Cheap wide spectrum antibiotic DOC of otitis media |
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Definition
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Term
| Common SE of spironolactone |
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Definition
| Gynecomastia and hyperkalemia |
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Term
| DOC for tx of pseudomembranous colitis |
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Definition
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Term
| Increase bone density, also being tested for breast CA tx. |
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Definition
| Raloxifene (SERM-selective estrogen receptor modulator) |
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Term
| Interaction with this drug requires dose reduction of 6-MP |
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Definition
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Term
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Definition
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Term
| Most widely used thyroid drugs such as Synthroid and Levoxyl contain |
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Definition
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Term
| Selective estrogen receptor modulator (SERM) used for prevention of osteoporosis and currently being tested for treatment of breast cancer (Stars study) |
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Definition
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Term
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Definition
| Blocks peptidoglycan synthesis |
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Term
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Definition
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Term
| 2nd generation antihistamines |
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Definition
| Fexofenadine, loratadine, and cetirizine |
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Term
| A1a-selective blocker used for BPH |
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Definition
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Term
| Ability of drug to produce a biologic effect |
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Definition
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Term
| Ace inhibitors are contraindicated in |
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Definition
| pregnancy and with hyperkalemia |
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Term
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Definition
| Antipyretic and analgesic activity |
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Term
| Activation of these receptors close Ca2+ ion channels to inhibit neurotransmitter release and pain transmission |
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Definition
| Presynaptic mu, delta, and kappa receptors |
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Term
| ADH agonist used for pituitary diabetes insipidus |
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Definition
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Term
| Agent for pernicious anemia |
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Definition
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Term
| Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol-oxidizing system (MEOS) |
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Definition
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Term
| Agent used for anemias associated with renal failure |
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Definition
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Term
| Agent used for closure of patent ductus arteriosus |
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Definition
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Term
| Agent used for megaloblastic anemia (but does NOT reverse neurologic symptoms) and decrease neural tube defects during pregnancy |
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Definition
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Term
| Agent with greater affinity to 5HT2A receptor; reserved for refractory schizophrenia, and can cause weight gain and agranulocytosis |
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Definition
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Term
| Allopurinol treats chronic gout by inhibiting |
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Definition
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Term
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Definition
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Term
| Alpha 1selective blockers |
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Definition
| Prazosin, terazosin and doxazosin (-AZOSIN ending) |
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Term
| Amino acid derivative for treatment of Type II diabetes |
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Definition
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Term
| Anemia caused by trimethoprim |
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Definition
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Term
| Angiotensin receptor blockers do NOT cause |
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Definition
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Term
| Anti-biotic frequently used for chronic UTI prophylaxis |
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Definition
| sulfamethoxazole/ trimethoprim |
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Term
| Antidote for acetaminophen toxicity |
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Definition
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Term
| Antidote to benzodiazepine overdose (antagonist that reverses the CNS effects) |
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Definition
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Term
| Antidote to reverse actions of heparin |
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Definition
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Term
| Antidote used for acetaminophen (APAP) toxicity |
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Definition
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Term
| Antidote used for benzodiazepine toxicity |
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Definition
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Term
| Antidote used for opioid toxicity |
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Definition
| Naloxone (IV), naltrexone (PO) |
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Term
| Antidote used for warfarin toxicity |
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Definition
| Vitamin K and Fresh frozen plasma (FFP) |
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Term
| Anti-emetics used in association with anti-cancer drugs that are 5-HT3 (serotonin receptor subtype ) antagonist |
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Definition
| Odansetron, granisetron, dolasetron, palonosetron |
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Term
| Anti-microbials that cause hemolysis in G6PD-deficient patients |
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Definition
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Term
| Antipsychotics having the strongest autonomic effects |
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Definition
| Chlorpromazine or Thioridazine |
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Term
| Anti-psychotics shown not to cause tardive dyskinesia |
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Definition
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Term
| Antipsychotics, reserpine at high doses, and MPTP (by-product of illicit meperidine analog) and is irreversible |
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Definition
| Drug induced Parkinsonism |
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Term
| Anti-seizure drugs used also for pain of neuropathic orgin |
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Definition
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Term
| Atypical antipsychotic causing high prolactin levels |
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Definition
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Term
| Benzodiazepine receptor antagonist, it accelerates recovery from benzodiazepine overdose |
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Definition
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Term
| Blows DNA (breaks DNA strands), limiting SE is pulmonary fibrosis |
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Definition
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Term
| Bronchodilation in asthma and COPD |
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Definition
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Term
| Captopril and enalapril (-OPRIL ending) are |
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Definition
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Term
| Cardioselective Beta 1-blockers |
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Definition
| Atenolol, acebutolol, and metoprolol |
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Term
| Common side effect of Rifampin |
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Definition
| Orange urine discoloration |
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Term
| Converted to more active form DHT by 5 alpha-reductase |
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Definition
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Term
| Decreases liver triglycerol synthesis |
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Definition
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Term
| Distribution of histamine receptors H1, H2, and H3 |
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Definition
| Smooth muscle; stomach, heart, and mast cells; nerve endings, CNS respectively |
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Term
| Diuretic used for mountain sickness and glaucoma |
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Definition
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Term
| Diuretic used to antagonize aldosterone receptors |
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Definition
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Term
| Diuretic used to treat primary aldosteronism |
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Definition
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Term
| DMARDs are slow acting drugs for |
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Definition
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Term
| DOC for bipolar affective disorder |
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Definition
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Term
| DOC for giardia, bacterial vaginosis, pseudomembranous colitis, and trichomonas |
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Definition
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Term
| DOC for herpes and its MOA |
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Definition
| Acyclovir; activates thymidine kinase |
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Term
| DOC for influenza A and B |
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Definition
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Term
| DOC for malignant hyperthermia by acting on the sacroplasmic reticulum or skeletal muscle |
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Definition
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Term
| DOC for malignant hyperthermia that may be caused by use of halogenated anesthetics |
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Definition
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Term
| DOC for management of acute Ventricular arrhythmias |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Dopamine agonist used in hyperprolactinemia |
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Definition
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Term
| Drug causing depletion of substance P (vasodilator) |
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Definition
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Term
| Drug of choice for myoclonic seizures |
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Definition
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Term
| Drug or foods (grapefruit juice) that increase statin effect |
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Definition
| Inhibit Cytochrome P450 3A4 |
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Term
| Drug that causes contraction of the uterus |
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Definition
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Term
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Definition
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Term
| Drug used in neuroleptic malignant syndrome |
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Definition
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Term
| Drugs of choice for absence seizures |
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Definition
| Ethosuximide and valproic acid |
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Term
| Drugs of choice for generalized tonic-clonic and partial seizures |
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Definition
| Valproic acid, Phenytoin and Carbamazepine |
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Term
| Ergot alkaloid used as an illicit drug |
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Definition
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Term
| Fibrates (gemfibrozil) increase activity of |
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Definition
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Term
| H2 blocker that causes the most interactions with other drugs |
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Definition
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Term
| Heparin (PTT) increases activity of |
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Definition
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Term
| HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism |
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Definition
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Term
| Hormone inhibiting prolactin release |
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Definition
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Term
| Inducers of Cytochrome P450 (CYP450) |
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Definition
| Barbiturates, phenytoin, carbamazepine, and rifampin |
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Term
| Inhibit angiotensin-converting enzyme (ACE) |
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Definition
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Term
| Inhibitor of lipoxygenase |
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Definition
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Term
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Definition
| Cimetidine, ketoconazole, erythromycin, isoniazid and grapefruit |
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Term
| Life threatening cardiac event that prolong QT leads to |
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Definition
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Term
| Limiting side effect of Quinidine |
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Definition
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Term
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Definition
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Term
| Loops lose and thiazide diuretics retain |
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Definition
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Term
| Losartan and valsartan block |
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Definition
| Angiotensin receptor blockers (ARB) |
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Term
| Major effect of benzodiazepines on sleep at high doses |
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Definition
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Term
| Major route of elimination for Lithium |
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Definition
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Term
| May protect against doxorubicin cardio-toxicity by chelating iron |
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Definition
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Term
| Mechanism of action (MOA) utilizes intracellular receptors |
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Definition
| Thyroid and steroid hormones |
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Term
| Mediator of tissue pain, edema, inactivated by ACE, and may be a contributing factor to the development of angioedema |
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Definition
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Term
| Meningitis prophylaxis in exposed patients |
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Definition
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Term
| Methyldopa is contraindicated in |
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Definition
| Geriatrics due to its CNS (depression) effects |
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Term
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Definition
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Term
| MOA and effect of nitric oxide |
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Definition
| Stimulates cGMP which leads to vascular smooth muscle relaxation |
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Term
| MOA of class I A (eg. Procainamide), class IB (eg. Lidocaine), and class IC (eg. Flecainide) antiarrhythmics |
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Definition
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Term
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Definition
| Relax vascular smooth muscle, at low doses dilate veins and at high doses dilate arterioles |
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Term
| MOA of sildenafil (Viagra) |
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Definition
| Inhibits phosphodiesterase-5, enhancing effects of nitric oxide-activated increases in cGMP |
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Term
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Definition
| Inhibit dihydropteroate synthase |
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Term
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Definition
| Lyse thrombi by catalyzing the formation of plasmin which binds fibrin |
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Term
| MOA utilizes transmembrane receptors |
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Definition
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Term
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Definition
| Codeine, hydrocodone, and oxycodone |
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Term
| Monitoring parameter to obtain before initiation of STATINS |
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Definition
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Term
| Muscarinic antagonist used in asthma |
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Definition
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Term
| Non-steroidal estrogen agonist causes clear cell adenocarcinoma of the vagina in daughters of women who used it during pregnancy |
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Definition
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Term
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Definition
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Term
| Opioid antagonist that is given IV and had short DOA |
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Definition
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Term
| Opioid antagonist that is given orally in alcohol dependency programs |
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Definition
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Term
| Opioid associated with awareness during surgery and post-operative recall, but still used for high-risk cardiovascular surgeries |
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Definition
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Term
| Opioid available trans-dermally |
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Definition
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Term
| Opioid that can be given PO, by epidural, and IV, which helps to relieve the dyspnea of pulmonary edema |
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Definition
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Term
| Opioid used in the management of withdrawal states |
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Definition
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Term
| Osmotic diuretic used for increased intracranial pressure |
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Definition
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Term
| Patients being treated with lithium, who are dehydrated, or taking diuretics concurrently, could develop |
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Definition
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Term
| Pneumonic for beta receptors |
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Definition
| You have 1 heart (Beta 1) and 2 lungs (Beta 2) |
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Term
| Potassium sparing diuretics inhibit |
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Definition
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Term
| Produce mydriasis and cycloplegia |
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Definition
| Atropine, homatropine, and tropicamide |
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Term
| Product of proinsulin cleavage used to assess insulin production |
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Definition
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Term
| Prostaglandin used in the treatment impotence |
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Definition
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Term
| Prostaglandins that cause abortions |
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Definition
| Prostaglandin E1 (misoprostol) PGE2, and PGF2alpha |
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Term
| Prototype antagonist of H1 and H2 receptors |
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Definition
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Term
| PTU (propylthiouracil) MOA |
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Definition
| Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin |
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Term
| Readily detected markers that may assist in diagnosis of the cause of a drug overdose include |
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Definition
| Changes in heart rate, blood pressure, respiration, body temperature, sweating, bowel signs, and pupillary responses |
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Term
| Reason benzos are used cautiously in pregnancy |
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Definition
| Ability to cross the placenta |
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Term
| Reduce heart rate, contractility, and O2 demand |
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Definition
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Term
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Definition
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Term
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Definition
| Paresthesias, alkalization of the urine (which may ppt. Ca salts), hypokalemia, acidosis, and encephalopathy in patients with hepatic impairment |
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Term
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Definition
| Orthostatic hypotension (especially with first dose) and reflex tachycardia |
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Term
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Definition
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Term
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Definition
| Bradycardia, SEXUAL DYSFUNCTION, decrease in HDL, and increase in Triglycerols (TG) |
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Term
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Definition
| Constipation, edema, and headache |
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Term
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Definition
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Term
|
Definition
| Tremor, sedation, ataxia, aphasia, thyroid enlargement, and reversible diabetes insipidus |
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Term
| SE of long term (>5 days) corticosteroid therapy and remedy |
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Definition
| Adrenal suppression and weaning slowly, respectively |
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Term
| SE of loop (furosemide) diuretics |
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Definition
| Hyperuricemia, hypokalemia and ototoxicity |
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Term
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Definition
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Term
|
Definition
| Gingival hyperplasia, nystagmus, diplopia and ataxia |
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Term
|
Definition
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Term
|
Definition
| Gynecomastia hyperkalemia, and impotence |
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Term
| SE of thiazide (HCTZ) diuretics |
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Definition
| Hyperuricemia, hypokalemia and hyperglycemia |
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Term
| Selective Alpha 1 blocker used for hypertension, BPH, may cause first dose orthostatic hypotension |
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Definition
| Prazosin, terazosin, doxazosin |
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Term
| Selective B1 Receptor blockers that may be useful in treating cardiac conditions in patients with asthma |
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Definition
| Acebutolol, atenolol, esmolol, metoprolol |
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Term
| Side effects occuring in antipsychotics that block dopamine |
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Definition
| EPS, hyperprolactinemia, amennorrhea, galactorrhea, neuroleptic malignant syndrome |
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Term
| Site of action of loop diuretics |
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Definition
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Term
| Site of action of thiazide diuretics |
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Definition
| Work at early distal convoluted tubule |
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Term
| Some side effects of corticosteroids |
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Definition
| Hyperglycemia, Osteopenia, impaired wound healing, inc. risk of infection, inc. appetite, HTN, edema, PUD, euphoria, psychosis |
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Term
| Synthetic analog of ADH hormone used for diabetes insipidus and nocturnal enuresis |
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Definition
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Term
| System that increases in activity with chronic exposure and may contribute to tolerance |
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Definition
| Microsomal ethanol oxidizing system MEOS |
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Term
| TCA used in chronic pain, enuresis, and OCD |
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Definition
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Term
| Technique used to diagnose perianal itching, and the drug used to treat it |
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Definition
Scotch tape technique
and mebendazole |
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Term
| THC is active ingredient, SE's include impairment of judgment, and reflexes, decreases in blood pressure and psychomotor performance occur |
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Definition
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Term
| The most common neurologic abnormality in chronic alcoholics |
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Definition
| Peripheral neuropathy (also excessive alcohol use is associated with HTN, anemia, and MI) |
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Term
| These agents are CNS depressants |
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Definition
| Ethanol, Barbiturates, and Benzodiazepines |
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Term
| These agents decrease blood flow or increase blood pressure, are local decongestant, and used in therapy of spinal shock (temporary maintenance of blood pressure which may help maintain perfusion) |
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Definition
|
|
Term
| These Beta blockers decrease aqueous secretion |
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Definition
| Timolol (nonselective), betaxolol (selective) |
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Term
| Thioamide less likely to cross placenta, inhibits peripheral conversion of T4 to T3 in high doses, and should be used with extreme caution in pregnancy |
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Definition
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Term
| This agent has greater affinity for muscarinic receptors and used for postoperative and neurogenic ileus and urinary retention |
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Definition
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|
Term
| This agent may cause more severe, rapid and intense symptoms (abstinence syndrome) to a recovering addict |
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Definition
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Term
| This beta blocker lacks local anesthetic activity (decreases protective reflexes and increases the risk of corneal ulceration) and used in treating glaucoma |
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Definition
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|
Term
| This is the drug of choice for anaphylactic shock |
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Definition
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Term
| Thrombolytics are used for |
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Definition
| Pulmonary embolism and DVT |
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Term
| Time it takes for amount of drug to fall to half of its value, constant in first order kinetics (majority of drugs) |
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Definition
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Term
| Tolerance to all effects of opioid agonists can develop except |
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Definition
| Miosis, convulsions and constipation |
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Term
|
Definition
| DUMBELSS (diarrhea, urination, miosis, bronchoconstriction, excitation of skeletal muscle and CNS, lacrimation, salivation, and sweating) |
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Term
| Treat manifestations of Parkinson's disease and EPS |
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Definition
| Benztropine, trihexyphenidyl |
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Term
| Treatment for TB patients (think RIPE) |
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Definition
| Rifampin, Isoniazid, Pyrazinamide, and Ethambutol |
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Term
| Treatment of motion sickness |
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Definition
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Term
| Treatments available for nicotine addiction |
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Definition
| Patches, gum, nasal spray, psychotherapy, and bupropion |
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Term
| Unicyclic antidepressant least likely to affect sexual performance, used for management of nicotine withdrawal, SE's include dizziness, dry mouth, aggravation of psychosis, and seizures |
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Definition
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Term
| Used in pediatrics to maintain patency of ductus arteriosis |
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Definition
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Term
| Used intranasally and decreases bone resorption |
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Definition
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Term
| Vitamin K dependent anticoagulant |
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Definition
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