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High Yield for Geri Drugs
Overbeck Style Attention to Detail
68
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04/07/2012

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Term
Scopolamine, Diphenydramine, Dimenhydrinate, Meclizine, Promethazine
Definition
Motion Sickness
Term
Paroxetine, Amitryptyline
Definition
CI - concurrent MAO-i use
Term
Diphenoxylate + Atorpine
Definition
Common ADR - pancreatitis
Term
Ondansetron
Definition
Common ADR - QT Prolongation
Term
Ondansetron
Definition
CI - Concurrent use of Apomorphine
Term
Heparin
Definition
Follow PTT
Term
Warfarin
Definition
Follow PT
Term
Digoxin
Definition
Indication - CHF, A fib/flutter
Term
Aspirin
Definition
Toxicity - gastric ulceration, bleeding, hyperventilation, tinnitus (damage to CN 8)
Term
Clopidogral
Definition
MOA - Inhibit platelet aggregation by irreversibly blocking ADP receptors. Inhibit fibrinogen binding by preventing glycoprotein IIb/IIIa expression.
Term
Atorvastation, Simvastatin, Pravastatin
Definition
Common ADR - rhabdomyolysis, tendon rupture, hepatotoxicity
Term
Isosorbide Mononitrate
Definition
ADR - severe hypotension, METHEMOGLOBINEMIA
Term
Amiodarone
Definition
ADR - pulmonary fibrosis, hepatotoxicity, hypothyroidism/hyperthyroidism (Recall - Drug is 40% iodine by wgt, so it's thyroid effects are significant.)
Term
Midrodrine
Definition
Indication - Orthostatic Hypotension
Term
Citalopram, Fluoxetine, Sertaline, Paroxetine
Definition
ADR - Serotonin Syndrome (ass w/ muscle rigidity, hyperthermia, CV instability, flushing, diarrhea, seizures)
Term
Amitryptiline
Definition
Toxicity - 3 C's = coma, cardiac arrythmia, convulsions
Term
Bupropion
Definition
Indication - depression, smoking cessation
Term
Trazodone
Definition
ADR - PRIAPISM, sedation, nausea, postural hypotension
Term
Mirtazapine, Olanzapine
Definition
Side Effect (often beneficial) - INC appetite, wgt gain
Term
Alprazolam, Diazepam, Lorazepam, Clonazepam
Definition
2x - 4x INC in risk for FALLS. Related to dose and postural sway.
Term
Risperisone, Aripiprazole, Quetiapine, Olanzapine, Haloperidol
Definition
Black Box Warning for FALLS when used in Dementia Pt
Term
Haloperidol
Definition
ADR - significant extrapyramidal sx, such as dystonia, akinesia, restlessness, and tardive dyskinesia
Term
Rosiglitazone, Pioglitazone
Definition
MOA- INC insulin sensitivity in peripheral tissues by binding PPAR-gamma nuclear transcription regulator
Term
Rosiglitazone, Pioglitazone
Definition
CI - CHF Class III/IV, liver impairment
Term
Insulin Glargine
Definition
Indications - DM Type I, DM Type II
Term
Glipizide, Glyburide, Glimepriride, Stigliptin
Definition
MOA - INC insulin production by closing K+ channels in beta cell membrane.
Term
Thiazide
Definition
1st line anti-HTN for elderly
Term
Metoprolol, Carvediol
Definition
Caution - Negatively Ionotropic - Use with caution in elderly patient with conduction abnormality
Term
Lisinopril, Enalapril
Definition
Preferentially used in HTN pt with co-morbid conditions such as DM, CHF, LVH, and renal insufficiency
Term
Furosemide
Definition
ADR - Ototoxicity
Term
Hydrochlorothiazide
Definition
ADR - Hypokalemia, Hyponatremia, Hyperuricemia, Dehydration
Term
Amlodipine, Diltiazem
Definition
MOA - Block voltage-dependent L-type Ca++ channels
Term
Oxybutynin, Tolterodine, Darifenacin
Definition
Indication - Overactive Bladder
Term
Doxazosin, Terazosin, Tamsulosin, Finasteride
Definition
Indication - BPH
Term
Finasteride
Definition
MOA - 5 -alpha-reductase inhibitor DEC the conversion of Test --> DHT
Term
Doxazosin
Definition
ADR - leukopenia, neutropenia
Term
Terazosin
Definition
Potentiated by HTN medication
Term
Finasteride
Definition
ADR - DEC in libido, DEC in ejaculate, Impotence
Term
Rivastigmine
Definition
Cholinesterase inhibitor that does NOT interact with drugs that alter activity P450 dependent enzymes
Term
Donepezil, Galantamine
Definition
Cholinesterase inhibitors that are substrates for P450 and can alter activity of P450 enzymes.
Term
Nemantadine
Definition
MOA - Block NMDA ion channels to limits Ca++ influx into neuron
Term
Omeprazole
Definition
ADR - INC incidence of C. diff colitis and diarrhea, LOW B-12
Term
Alenodronate, Risedronate, Ibandronate
Definition
ADR - esophagitis, eophageal ulcers
Term
Raloxifene
Definition
INC risk for invasive breast cancer, stroke, venous thromboembolism, and coronary artery disease.
Term
Teriparatide
Definition
CI - Pt w/ pre-existing hypercalcemia
Term
Denosumab
Definition
CI - Pt w/ hypocalcemia
Term
Denosumab
Definition
MOA - Blocks RANKL to prevent formation of osteoclasts
Term
Carbidopa-Levodopa
Definition
Caution:
HTN crisis caused in pt taking MAO-i
INC intraocular pressure in Glaucoma Pt
Possible arrhytmia in cardiac Pt
Term
Allopurinol
Definition
Interferes w/ metabolism of 6-mercaptopurine (anti-cancer) and azathiopurine (immunosuppressant)
Term
Caffeine
Definition
MOA - Blocks adenosine receptors
Term
TCA's
Definition
Fall Risk due to postural hypotension, sedation, arrythmia
Term
Fludrocortisone
Definition
Mineralocorticoid that causes volume expansion. Used to tx orthostatic hypotension
Term
NSAID's
Definition
Raise systemic vascular resistance
Term
Indomethacin/Octreotide
Definition
Include in Tx of Postprandial Hypotension
Term
Benzodiazepine
Definition
Can prolong normal or complicated grief
Term
SSRI
Definition
First line depression medication in elderly
Term
Metoformin
Definition
Less likely to cause hypoglycemia than SU/Insulin
Term
Metformin
Definition
In patient with creatine clearance over 1.5 and GFR over 60, lactic acidosis risk will be LOW.
Term
Alpha Antagonist
Definition
Avoid in elderly pt due to risk of rebound HTN
Term
Steroids, Sym Agonists, Decongestants, NSAID's, Cyclosporine, Tacrolimus, Erythropoietin
Definition
Medications known to INC BP
Term
Calcitonin
Definition
Analgesic effect in pt w/ vertebral fractures
Term
Amlodipine, Diltiazem
Definition
Assoc w/ lower extremity edema
Term
Anti-Cholinergics
Definition
ADR - urinary retention, constipation, delerium, dry mouth, blurred vision, increased HR
Term
Capsaicin
Definition
Poorly tolerated due to local skin effects
Term
Oxybutynin
Definition
Anticholinergic used to tx detrusor overactivity
Term
Cholinergic
Definition
Tx of detrusor underactivity
Term
Pseudoephedrine
Definition
Alpha agonist that tightens sphincter in stress incontinence.
Term
Alpha Blocker
Definition
Causes bladder sphincter relaxation
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