Term
| three components of diffusion |
|
Definition
diffusion positive movmenet orm high to low concentration
not bulk flow
gas transfer
more accurate term in the bological sysytem |
|
|
Term
|
Definition
| the time rbc takes to in alveoli |
|
|
Term
|
Definition
| gas flux through a membrane os detemined by the pressure difference and the conductive properties of the membrane |
|
|
Term
|
Definition
| gas flux through a membrane os detemined by the pressure difference and the conductive properties of the membrane |
|
|
Term
|
Definition
| diffusion contant and area and the difference of pressure and the solubility |
|
|
Term
|
Definition
| thickness and molecular weight |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| phsyiologically inert gases |
|
Definition
N2 N2O acetylene
no reaction with HgB
small, highly soluable |
|
|
Term
| wehn the pressure gradeint=0, the onyl way to tranfer more N20 is to supply new more |
|
Definition
|
|
Term
| Carbon monoxide is not inert it binds to Hg |
|
Definition
produces negliginble rise in capillary CO pressure
all CO rapidly bound to HgB
pressure difference persists across the alveolar-capillary barrier
there remains a difference in driving pressure |
|
|
Term
| PCo gradiuest exists across the alveolar capillary barrier at the ned of capillary flow |
|
Definition
| characteristics of the membrane determine the flow. |
|
|
Term
|
Definition
|
|
Term
| oxygen crosses alveolar membrane quickly and |
|
Definition
|
|
Term
| o2 quickly equilibriates with |
|
Definition
|
|
Term
| onlky a small fraction of bulk moles of oxygen is |
|
Definition
|
|
Term
| what about hte complication of patholigc conditions? you have low alveolar pressure or thickened alveolar membrane |
|
Definition
we normally have alveolar pressure of 100 percent. Palv of 40 is woefully lwo. if there is a laot of extraction..you have a capilalry pressure P20. In us it is 100 P alv to 35P cap.we have a 65 mmHg driving force.
in disease state, alveolar pressure is quite low and pcap is low low driving pressure.
Therefore we get low diffusion of oxygen...we have changed a perfusion limited to a diffusion limited situation gas. |
|
|
Term
|
Definition
we get only still alimited time of transfer
lower o2 pressure |
|
|
Term
|
Definition
| causes thickening of the barrier between alveoli and capilalry. |
|
|
Term
|
Definition
| HgB binding but reverse reaction. |
|
|
Term
|
Definition
| also involves capillary blood volume |
|
|
Term
| capillary blood volume has little to do with membrane but lots to do with |
|
Definition
|
|
Term
| conditions that decrease DlCO 9testable) |
|
Definition
thickened barrier (fibrosis alveolar edema)
decreased perfused alveolar surface area (emphysema, pulmonary embollism decreased blood volume)
reducedgs up take by RBCs (anemia) volume |
|
|
Term
|
Definition
icnrease rbc volume
high outpu
mitral stenosis
CHF early
asthma exacerbaton |
|
|
