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3 types of mycobacter organisms |
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Definition
mycobacter tb mycobacter leprosae mycobacter avium intracellulare complex |
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what percent of the world's population is infected yearly with tuberculosis |
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Definition
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how many deaths annually from tb? |
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what percent of the world's population is currently infected with tb? |
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Definition
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obligate thus it is in the lung |
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Tb is fast or slow growing? |
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Definition
slow-difficult to culture |
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Definition
acid fast...high lipid content of the cell wall. lightly gram positive |
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Definition
usually confined to lung, asymptomatic, detected by PPD test. Ghon complex is a calcified granuloma in the middle or lower lung along with perihilar nodes which are calcified. |
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Term
secondary or reactivated tuberculosis |
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Definition
m tuberculosis is notkilled by the host immune but rather walled off in granulomas. Reactivation can happen |
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In what percent of people does tuberculosis never reactivate? |
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Definition
90 percent of people with a primary infection and no other risk factors never reactivate. |
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Diabetics have a ___ percent of secondary reactivation |
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Definition
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HIV/ silicosis patients have a ___ percent chance for reactivation |
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Definition
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Symptoms of secondary tuberculosis |
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Definition
fever, weight loss, productive cough with yellow white sputum and hemoptysis. reactivation can occur in lung kidney cns bone elsewhere. |
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Definition
millet seeds tubercles disseminated over body. |
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Definition
tb is common secondary infection to hivboth due to new and reinfections. -faster -worse -no cavitation |
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Definition
ppd-48-72 hours later immuno compromised people may not respond to tb due to anergic t cells. |
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Definition
5mm-+chest, immunosuppressed, close contact 10mm akk others 15 mm-low risk person 4 or older |
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Is culture a good idea with tb |
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Definition
would work but not well as it is a slow growing organis, |
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sputum smear used to detect TB? |
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Definition
yes because it is fast and cheap, but it is not as sensitive as culture. |
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What stain should i use to diagnose tb? |
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sputum and cultures negative |
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Definition
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sputum and or cultures positve |
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is a person with a positive ppd a tb case? |
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no not if in latent state |
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Definition
Rifampin Isoniazid Pyrazinamide Ethambutol isoniazid pyrazinamide rifampin ethambutol |
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Term
SHould you identify and treat skin test positive people |
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Definition
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debatable efficacty, causes skin test positivity. |
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Definition
political commitment microscopy uninterrupted supply of drugs surveillance and monitoring directly observed treatment for 6-8 months. |
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mycobacterium other than tb |
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Definition
not transmissible only culture diagnosed difficult to treat not a public health con cern no tracking systems |
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Definition
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tuberculosis is in the top ___ infectious killers in the world |
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right upper lobe infiltrate pneumonia with cavity? |
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Definition
cavitatous upper r upper lobe pneumonia |
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Term
Ziehl Neelson and Kinyoum stains |
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Definition
stains used in past carbol fuschin mycolic acid uptake |
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required for dagnosis of tb |
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Term
THey used to use lowenstein jensen agar and middlebrook agar, now they use |
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Definition
bactec mgit-13 week average culture time |
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lowenstien jensen agar is |
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droplet nuclei from one person to another through air |
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once you inhale a droplet nuclei |
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Definition
enters the lung alveoli. tubercle bacilli mutliply in the alveoli small number of bacilli enter blood stream and establish infection in distant sites |
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2-10 weeks after infection |
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Definition
we create the hard shell. if we control we are laten otherwise active. |
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most common immunouppressive disease int he US |
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Definition
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outside exposure vs inside |
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Definition
outside much better less risky |
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8-10 active hours needed to |
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Definition
ensure transmission can happen with less |
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most common location of tb |
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Definition
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more bacterial load youhave |
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Definition
greater number of infectious droplets creted |
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Definition
5-10 K bacilli/ml sputum negative can still transfer |
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in hospital, how do we decrease chance of transmission? |
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Definition
pump air outside wear mask |
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Term
if you have never had tb you are more/less likely to get tb from a particular person than someone who has had tb |
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Definition
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world average tb incidence |
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Definition
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where can you find high rates of tb |
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Definition
immigrants, borders, natives |
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Definition
bacillus calmette guerin intradermal used outside europe japan usa less efficacy against adult than children |
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who do you want to screen for tb |
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Definition
congregate living health care workers active latent tb |
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Term
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Definition
based on the production of interferon gamma by lymphocytes in response to TB antigens
not produced by bcg vaccine strains |
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Term
varicella, hiv, tb, herpes |
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Definition
can all hide in places to evade immune system |
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Term
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Definition
fever, night chill, sweat, loss appetite, loss weight, easy tired, hemoptysis. |
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9 months isoniazid 4 months ripamfin inh and ripamfin 4 months |
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61-91 percent effective increase |
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ripe for 2 months ir for 4 months |
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nontuberculous mycobacetium mycobacterium other than tuberculosis |
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