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HHD Kao Pulmonary Blood Flow
Also West Ch. 4
42
Medical
Professional
04/07/2009

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Term
pressures on the right side are lower than the left side-explain the pathology
Definition
if you have left to right shunting, hihg pressure goes to right atrium side and then is sent back to the lungs. This will lead to over oxygenated blood

you can develop pulomary hypertensio- long term consequense right side exceed to left side
Term
a right to left shunt
Definition
air flows from right to left
never having touched air
this leads to depxygenated blood and cyanosis
keisenmengers pulmonary vascular disease
Term
right ventricle of 100
Definition
can still live for 20-30 years along the way trashing their pulmonary circulation...fatal disease
Term
good venous saturation
Definition
65 percent
Term
pulmonary artieries branch with
Definition
airways and then go till the terminal bronchioles thebn branch and create s heet of blood interrupted by alveolar wall
Term
distance from alevolars to artery
Definition
.3 microns
surfactant
alvelor i
intersit
endo
plasma
redcell
Term
pulmonary blood vessels are
Definition
thin
littl esmooth muscle
Term
systemic arterioles are
Definition
muscular and have abundant smooth muscle to regulate blood flow to various organs
Term
BMP 2
Definition
exagerrated proliferation
meth or cocaine, virus
exagerrated inflammatory response
Term
pulomanry circulation must accept
Definition
all the blood
Term
Pulmonary vascular resistance
Definition
pressure difference in lung/cardiac output
Term
PVR relation to SVR
Definition
1 to 10
Term
passive factors that affect pulomary vascular resistance
Definition
cardiac output/hydrostatic change
lung volumes/inhalation
lung position/gravity/orthostatic change
positive pressure ventilation
Term
active things that cause pulmonary resistance
Definition
acidemia
hypoxia
sympathetic tone
hypercapnia-too much CO2
Term
Pulmonary vascular resistance in some cases can become _____ as pressures rise
Definition
lower
Term
How does pulmonary vascular resistance become lower in the face of increased pressure
Definition
recruitment and distension
Term
pulmonary capillaries ar esurrounded by
Definition
alveolar gas
Term
alveolar gas can collapse the
Definition
capillaries
Term
pulmonary arteies and veins pressure around them may be less than the alveolar pressure due to
Definition
radial traction
Term
deep breath in
Definition
extra alveolar vessels
expand
Term
vascular resistance from low to high
Definition
very low to middle it decreases
then it increases
Term
at low lung volumes, extraalveolar vessels
Definition
small caliber due to their intrinsic smooth muscle/elastic tisse
Term
critical opening pressure
Definition
the pressure necessary to initiate blood flow through pulmonary vessels within a collapsed lung
Term
at large lung volumes vascular resistance
Definition
increases due to stretched alveolar walls
Term
where is resitance lowest
Definition
functional residual capacity
Term
more ventilation and blood flow
Definition
bottom of lung
Term
zone 1
Definition
P alveolar>parterial>pvenous
no flow
pathological condition
shock
ventilated but not perfused
Term
zone 2
Definition
parterial.palveolar.pvenous
blood flow dictated by the difference between parterial and palvolar
waterfall
starlings
Term
zone 3
Definition
parterial.pvenous.palveoli
Term
zone 4
Definition
atalactatic lung
blood vessels and alveoli collapse
Term
____ factors dominate PVR and blood flow distribution normally
Definition
passive
Term
HPV
Definition
hypoxic pulmonary vasconstircitoon.

no cns
occurs in excised segement of pulmonary artery
the PO2 of alveolar gas no thte arterioklar blood
Term
HPV is is not linear
Definition
non linear
when pO2 is below 70 mm Hg lots of vasoconstiction
Term
HPV Causes blood to flow to or way from hypociv regions
Definition
away
Term
nitric oxide is a vaso_____-
Definition
dilator
reduces HPV
Term
viagra
Definition
suldenofil
improvign downsttream cyclic g protein
vasodialtor
may promote endothelial formation
Term
in utero
Definition
hpv very high
then breath
relaxation of smooth muscle tone
Term
keep water out
Definition
starling's law
fluid out
hydrostatic
fluid in
colloid
Term
lymph produced due to
Definition
capilalry leak out
Term
where does lymph go
Definition
interstitium around the extralveolar vessels
perivascular and peribronchial lymphatics
drain into hilar nodes
Term
hydrostatic pressure out
colloid pressure___
Definition
in
Term
V/Q
Definition
mismatch contributes to hypoxemia
and dead space ventilation
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