Shared Flashcard Set

Details

Herbals
sem4 mini2
30
Pharmacology
Professional
03/06/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Valerian
Definition
MOA: may have affinity for GABAa receptor
may be agonist for adenosine A1 receptor

uses: insomnia, anxiety

A/E: headache, dizziness, GI upset, fatigue morning after

C/I: pregnancy, breastfeeding
Term
St. John's Wort
Definition
MOA: inhibits reuptake of serotonin, NE, DA

uses: depression, anxiety, sleep disorders, nerve pain related to HSV

A/E: photosensitivity, anxiety, dry mouth, dizziness, GI upset, fatigue, sexual dysfunction
Term
C/I: Pregnancy, breastfeeding
Definition
EVERYTHING but:
arnica
cranberry
echinacea
ginger

(So these can't have it happen):
Valerian
St. John's Wort
Saw palmetto
milk thistle
licorice
horse chestnut seed extract
hawthorn
gingko
feverfew
black cohosh
aloe vera
Term
Saw palmetto
Definition
MOA: inhibits 5 alpha reductase, blocks androgen receptor in prostate, blocks alpha 1 receptors, inhibits components of IGF-1 signalling pathway, anti-inflammatory

uses: BPH, chronic pelvic pain in women

A/E: GI upset, breast tenderness, decreased libido

C/I: hormone-dependent cancers
Term
Milk thistle
Definition
MOA: antioxidant, reduces inflammatory LTs, helps transcribe liver proteins

uses: liver and GB disease
antidote to Amanita mushroom poisoning

A/E: mild GI/diarrhea, may lower blood sugar

C/I: allergy to plants in aster/daisy/sunflower family
Term
Licorice as DGL extract
Definition
MOA: releases endogenous secretin, which increases mucous coating in GI tract

uses: gastric/duodenal non-H. pylori ulcer
bronchitis
sore throat
hepatitis

A/E: GI, diarrhea
Term
Horse Chestnut Seed Extract
Definition
MOA: inhibits elastase and hyaluronidase, which breaks down collagen in capillary walls

uses: chronic venous insufficiency
varicose veins
hemorrhoids

A/E: itching, nausea, GI upset

C/I: raw or homemade preps!! these contain *ESCULIN*, which is toxic; diabetes, hypoglycemia, <18 yo

interactions: diabetes meds
Term
Hawthorn
Definition
MOA: dilates coronary vessels, increases HR, diuretic, anti-oxidant

uses: mild CHF, angina, HTN

A/E: headache, nausea, dizziness, palpitations

C/I: children

ineractions: may potentiate anti-arrhythmics, inotropes, b-blockers, cardiac glycosides
Term
Gingko
Definition
MOA: anti-oxidant
anti-inflammatory
inhibits platelet aggregation
induces vasodilatin
possible neuroprotective effect

uses: Alzhemier's, dementias, memory enhancement, intermitten claudication (calf pain), impotence, MS, tinnitus, vertigo

A/E: dizziness, GI, allergic dermatitis

C/I: raw or cooked seeds!! they contins **____TOXIN**, which can cause seizures, death

interactions: drugs metabolized by cyp450, anti-coagulants, anti-platelets, NSAIDs, trazodone
Term
Ginger
Definition
MOA: phenolic and sesquiterpene compounds, which have anti-emetic, anti-inflammatory, anti-platelet props, increases GI motility

uses: N&V, motion sickness, osteoarthritis, low back pain

A/E: heartburn, dermatitis

C/I: allergy, gallstones, bleeding problems

interactions: anti-coagulants, anti-platelets, some chemotherapy meds
Term
Feverfew
Definition
MOA: anti-inflammatory, anti-paltelet, anti-tumor; maybe via parthernolide, a sesquiterpene lactone

uses: migraine prophylaxis, RA, cancer

A/E: GI upset, oral irritation

C/I: allergy to plants in aster/daisy/sunflower family

interactions: anti-coagulants, NSAIDs, anti-platelets, thrombolytics
Term
What has anti-inflammatory effects?
Definition
aloe vera
arnica
echinacea
feverfew
ginger
gingko
milk thistle (reduces inflammatory LTs)
saw palmetto (but first think androgen blocker)
Term
Echinacea
Definition
MOA: anti-inflammatory, activates macrophage cytotoxic activity against microorganisms and tumor cells

uses: (orally) cold, flue, URI; (topically) boils, acne

A/E: rash, asthma, anaphylactic in allergies, GI upset

C/I: allergy to plants in aster/sunflower/daisy/chrysanthemum/ragweed, autoimmune diseases

interactions: immunosuppressant drugs
Term
C/I: allergy to plants in aster/daisy/sunflower family
Definition
Arnica
Echinacea
Feverfew
Milk thistle
Term
Cranberry
Definition
MOA: acidifies urine and prevents E. coli bacteria adherance to bladder wall

uses: UTI, ulcer causes by H. pylori, dental plaque

A/E: GI upset, diarrhea

C/I: none

interactions: none
Term
What cause GI upset?
Definition
EVERYTHING but (these DON'T cause it):
aloe vera
arnica
ginger
hawthorn


(These cause it)
black cohosh
cranberry
echinacea
feverfew
gingko
horse chestnut seed extract
licorice
milk thistle
saw palmetto
St. John's wort
Valerian
Term
treats ulcers caused by H. pylori
Definition
cranberry
Term
treats non-H. pylori ulcers
Definition
licorice
Term
Black cohosh
Definition
MOA: partial agonist on serotonin receptors; no known estrogen properties

uses: menopausal symptoms, irregular menses, PMS, labor induction

A/E: headache, dizziness, (rare) hepatotoxic

C/I: liver disease
Term
Arnica
Definition
MOA: has helenalin, a sesquiterpene lactone, which is anti-inflammatory, anti-carcinogenic

uses: muscle sprain/strain, contusion, hematoma, osteoarthritis

A/E: (topical) contact dermatitis, irritation, burning

C/I: DO NOT USE ORALLY!!; allergy to plants in the aster/daisy/sunflower family; do not use on borken or damaged skin
Term
Aloe vera
Definition
MOA: anti-inflammatory, increases collagen content of granulation tissue

uses: (topically) burns, diabetic ulcers, skin lesions, insect repellant; (orally) esophageal, gastric/intestinal irritation, ulcverative colitis, constipation, diabetes

A/E: (oral) abdominal cramping, diarrhea, may decrease blood sugar

C/I: (topical) contact allergy; (oral) pregnancy, breastfeeding

interactions: diarrhea caused by laxative effect may dcrease absorption of other meds
Term
topical for burns, diabetic ulcers, other skin lesions
Definition
aloe vera
Term
arnica (helenalin)
feverfew (parthenolide)
ginger
Definition
herbals and their sesquiterpene lactones
Term
raw/homemade preps contain **ESCULIN**
Definition
horse chestnut seed extract
Term
releases endogenous secretin
Definition
licorice
Term
C/I: liver disease
A/E: hepatotoxicity
Definition
black cohosh
Term
treats liver and GB disease
Definition
milk thistle
Term
antidote to Amanita mushroom poisoning
Definition
milk thistle
Term
C/I: sun exposure
Definition
St. John's Wort
Term
treats insomnia, anxiety
Definition
Valerian
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