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Natural Products Association |
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Safety and quality standards; Online information |
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Nature Made, Nature Resource, Kirkland |
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proanthocyanidins prevent bacterial adhesion; cannot release bacterium |
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Cranberry drug interactions |
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Possibly effective for breast cancer reduction, menopausal symptoms, diabetes, hyperlipidemia |
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antagonizes estrogen receptors; Common ADRs: constipation, diarrhea, bloating, nausea; infrequent: insomnia, rash |
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MAOIs, warfarin, estrogens |
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Goiter and hypothyroidism in children; urinary bladder cancer |
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Cranberry Clinical Pearls: |
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On the FDA "generally recognized as safe" list; diabetics beware of sugar content; not an antibiotic substitute |
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"for a healthy urinary tract" |
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"Natural menopausal relief" |
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"For prostate and urinary health" |
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inhibit 5-alpha-reductase to lower dihydrotestosterone levels |
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Saw Palmetto drug interactions |
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Antiplatelet/anticoagulants, contraceptives, estrogens |
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Saw Palmetto Clinical Pearls |
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May cause erectile dysfunction, libido loss |
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Promotes heart and cholesterol health |
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alliin (odorless a.a.) --> allicin --> ajoene |
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antifungal like properties |
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Possibly effective for hypertension, atherosclerosis, tinea infections |
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Common ADRs: Malodorous breath and body GI irritation, flatulence, N/V/D; all dose related. Hypotension |
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isooniazide, NNRTIs, saquinavir, anticoagulant/antiplatelet drugs |
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Platelet dysfunction, prolonged bleeding time, rhinitis, conjunctivitis, allergic like reactions
Topical use: dermatitis, eczema, blisters, and scarring |
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Supports healthy brain function |
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flavonoids may protect tissues from oxidation; Ginkgolides inhibit platelet activation decreased aggregation improved blood flow |
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Possibly effective for age-related memory, cognitive function, dementia, peripheral vascular disease, and vertigo |
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Common ADRs: GI upset, headache, dizziness, palpitations, constipation, and allergic skin reactions |
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Antiplatelet/anticoagulant drugs, anti-diabetics, drugs that lower seizure threshold, trazodone |
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Risk of spontaneous bleeding, fresh seeds contain toxins--- seizures and death; likely unsafe in children |
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Promotes healthy liver function |
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inhibits TNF and beta-glucuronidase; Antioxidant or free radical-antagonizing actions from flavonoids |
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Possibly effective for allergic rhinitis and diabetes |
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Common ADRs: Nausea, diarrhea, dyspepsia, allergic like skin reactions |
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Relieves upper airway infections |
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Promotes TNF, Interleukin, and IL-1 release to increase lymphocyte activity |
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Possibly effective for the common cold and vaginal candidiasis |
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ADRs: N/V/D, constipation, rash and allergic reactions |
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Echinacea drug interactions |
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CYP1A2 and CYP3A4, caffeine, immunosuppressants |
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Echinacea clinical pearls |
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animal studies show high doses leads to reduced fertility |
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Clinically shown to relieve hot flashes and mood changes |
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May have estrogen-like effects (contoversial); May suppress pituitary secretion of luteinizing hormone |
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Possibly effective for menopausal symptoms |
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Common ADRs: GI irritation, rash, headache, dizziness |
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Black Cohosh drug interactions |
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Statins, cisplatin, CYP2D6 substrates |
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Black Cohosh Clinical Pearls |
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May cause liver toxicity; May increase risk of Endometrial hyperplasia, Thromboembolism and cardiovascular disease; No increase in surrogate markers of disease |
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Supports healthy emotional balance |
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Serotonin 5-HT 3/4 antagonist; Inhibition of serotonin, NE, dopamine reuptake; GABA and glutamate effects |
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Likely effective for depression, possibly effective for menopausal symptoms and wound healing |
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Common ADRs: Insomnia, vivid dreams, restlessness, anxiety, agitation, irritability, GI discomfort, diarrhea, fatigue, dry mouth, dizziness, headache |
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St. John's Wort Drug Interactions |
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All CYP3A4 and CYP2C9 substrates; Digoxin; serotonin modulating drugs |
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St. John's Wort Clinical Pearls |
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May cause mania in depressed patients. May resolve upon discontinuation; Withdrawal similar to that of SSRIs; May have teratogenic effects |
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Supports mental and physical vigor |
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Ginsenosides - insulin release and/or sensitization Induce monocytes, (TNF)-alpha, interferon-γ, IL-2 and natural killer cell activity |
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Likely effective for T2DM; Possibily effective for respiratory tract infections and mental performance |
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Common ADRs: Nausea, nervousness, insomnia, tachycardia; Similar rates to placebo |
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Ginseng Drug Interactions |
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Asian may prolong QT interval and reduce blood pressure; Risk of hypoglycemia (combination and mono); abuse syndrome |
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5-hydroxytryptophan; Hoodia; St. John’s Wort |
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Barley; Bean Pod; Blond Psyllium; Chitosan; Glucomannan; Guar Gum; Guggul; Inulin |
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Black Tea, Cocoa, Coenzyme Q10 |
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Casein Peptides; L-Arginine; Pomegranate |
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Corn Silk; Dandelion; Stinging Nettle |
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Digitalis; Hawthorn; Oleander; Pheasant’s Eye Star of Bethlehem |
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Banaba; Bitter Melon; Fenugreek; Gymnema |
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Agaricus Mushroom; American Ginseng; Cassia Cinnamon; Soy |
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Bean Pod; Blond Psyllium; Oat Bran; Soy |
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carbohydrate absorption inhibitors |
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Antiestrogens, Antioxidants, Fatty Acids, Selective Estrogen Receptor Modulators |
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Flaxseed, Red Clover, Soy |
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Selective Estrogen Receptor Modulators |
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Appetite Suppressants, Thermogenic Agents, Digestion Inhibitors |
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Fatty Acids, Vasodilators |
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ACE inhibitors, Diuretics, Positive Inotropes |
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Herbals for Heart Disease |
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Hypoglycemic Agents, Insulin Sensitizers, Carbohydrate Absorption Inhibitors |
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Sedatives/Hypnotics, Antidepressants, Miscellaneous |
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German Chamomile; Lavender; Lemon Balm; Valerian |
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Melatonin; Sour Cherry; Coenzyme Q-10 |
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Miscellaneous (for insomnia) |
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Alfalfa Black Cohosh; Chasteberry; DHEA; Flaxseed; Licorice; Red Clover;Soy; Evening Primrose Oil |
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Herbals for Menopausal Symptoms |
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5-Alpha-Reductase Inhibitors; Anti-proliferative; Anti-Inflammatories |
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5-Alpha-Reductase Inhibitor |
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African Wild Potato; Stinging Nettle Root; Soy |
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neurotransmitter modulators; neurotransmitter precursors |
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Stimulants, anxiolytics, other centrally acting agents |
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Inositol; Nicotinamide Adenine Dinucleotide Hydrate; S-Adenosyl-L-Methionine |
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Neurotransmitter Modulators |
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5-Hydroxytryptophan; Acetyl-L-Carnitine; L-Tryptophan; Phenylalanine; Phoephatidylserine; St. John’s Wort; Tyrosine |
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Neurotransmitter Precursors |
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Caffeine; Dimethylamylamine |
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German Chamomile; Lemon Balm; Passionflower; Valerian |
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Ginkgo; Melatonin; American Ginseng |
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other centrally acting agents |
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