Shared Flashcard Set

Details

Hepatitis
Hepatitis medsications, treatments, etc...
11
Pharmacology
Graduate
04/29/2012

Additional Pharmacology Flashcards


 

 


 

Cards

Term
Lamivudine
Definition

Treats Hep-B

 

MOA: Incorporates 3TC-triPO4 into DNA chains, resulting in chain termination

 

Not DOC in HBeAg-negative patients

 

Need dose adjustment when CrCl < 50

 

ADE: Well tolerated. Mild increase in ALT

Term
Adefovir dipivoxil
Definition

Treats Hep-B

 

MOA: Inhibits reverse transcriptase and DNA poly through chain termination

 

HBeAg positive and negative patients see a benefit

 

Requires dose adjustment when CrCl < 50

 

ADE: Nephrotoxicity

Term
Entecavir
Definition

Treats Hep-B

 

 MOA: Inhibits HBV replication at priming of DNA poly, reverse tx, synthesis of positive strand

 

HBeAg positive and negative patients see benefits

 

ADE: Can cause lamivudine resistance

Term
Telbivudine
Definition

Treats Hep-B

 

Adjust dose when CrCl < 50

 

ADE: High rate of resistance and cross-resistance to lamivudine. Myopathy and peripheral neuropathy.

 

 

Term
Tenofovir
Definition

Treats Hep-B and HIV

 

HBeAg positive and negative patients see benefits

 

Adjust dose when CrCl < 50

 

ADE: Fanconi syndrome, renal insufficiency, osteomalacia, decrease in bone density

Term
HCV- Genotype 2,3 Treatment Plan
Definition

PegINF + RBV therapy for 24 weeks

 

RBV: 800mg po qd

 

PegINF: 

2a: 180 micrograms SC weekly

2b: 1.5micrograms/kg SC weekly

Term
Genotype 1: Boceprevir Treatment Plan
Definition

Week 1-4: PegINF/RBV

 

Week 4-28: PegINF/RBV + Boceprevir 800mg q8h

 

If RVR is NOT achieved:

 

Week 4-36: PegINF/RBV + Boceprevir 800mg q8h

 

Week 36-48: PegINF/RBV

 

Term
Genotype 1: Telaprevir Treatment Plan
Definition

Week 1-12: PegINF/RBV + Telaprevir 750mg q8h

 

Week 12-24: PegINF/RBV

 

If RVR is NOT achieved:

 

Week 24-48: PegINF/RBV

Term
Boceprevir
Definition

Treats genotype 1 Hep-C

 

MOA: Inhibit NS3/4A protease and enhance host's defenses against the virus

 

Dosing: Take q7-9h with a light meal/snack

 

Refrigerate until dispensed

 

ADE: Anemia, neutropenia, vomiting, dysgeusia

Term
Telaprevir
Definition

Treats genotype 1 Hep-C

 

MOA: Inhibit NS3/4A protease and enhance host's defenses against the virus

 

Dosing: q7-9h with about 20g of fat in a meal

 

ADE: Rash, anemia, pruritis, anorectal burning, N/D

Term
Genotype 1: Initial HCV Treatment
Definition

PegINF alfa-2a:

PegINF: 180 mcg/week

RBV (qd): 1000mg if <  75kg, 1200mg if >75mg

 

PegINF alfa-2b:

PegINF: 1.5mcg/kg/week

RBV (qd):

<65kg: 800mg

65-85kg: 1000mg

85-105kg: 1200mg

>105kg: 1400mg

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