Term
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Definition
A descriptive term that refers to infection with any of the 6 hepatotrophic viruses. A, B, C,D, E, & G. |
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Term
| How is Hep A transmitted? |
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Definition
Fecal-Oral route Contaminated seafood/water etc.. |
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Term
| What is the incubation period of Hep A? |
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Definition
15-45d (3w average) Remember Hep A: abrupt onset Hep B: gradual onset Hep C: insidious onset. |
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Term
True or False A pt with Hep A is infectious for 2-3w in the late infection and early clinical course. |
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Definition
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Term
True or False ALT/AST is elevated 1-2w presymptoms in Hep A. |
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Definition
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Term
Concerning labs for Hep A, explain the difference between: |
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Definition
If positive, Hep A IgG shows past infection and lasts indefinately. If positive, Hep A IgM (moment) shows a current infection and can last up to 3-6m before it returns to normal.
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Term
| What is the adverse relationship that exists in the comorbid states of Hep A & Hep C. |
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Definition
| Hep A while normally the most begign of the 6 hepatitis, becomes an aggrevating factor to Hep C & worsens its outcome when they exist together. |
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Term
| What labs are ordered for the hepatitis pt? |
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Definition
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Term
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Definition
Anti HAV IgM it is present when s/s appear becomes negative when IgG pops up Pt will have life long immunity after.
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Term
| What is the tx for Hep A? |
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Definition
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Term
| Is it true that there is no chronic disease state of Hep A? |
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Definition
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Term
True or False Hep B is the only one of the Hepatitis to be considered an STD. |
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Definition
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Term
How is Hep B transmitted? |
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Definition
Sex (semen) Blood Saliva Mucous mem. Mom to fetus Tattoo parlors
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Term
True or False Hep B has a asymptomatic carrier state. |
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Definition
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Term
| What is one of the worse clinical courses in Hep B? |
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Definition
Submassive Hepatic Necrosis 60% fatality rate |
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Term
| What is the Hep B surface antigen? |
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Definition
| lab that is positive in the acute stage of infection. Usually positive in the 4th-12th week. |
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Term
True or False 80-90% of the time the Hep B surface antigen will disappear in about 3m. |
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Definition
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Term
True or False If the Hep B surface antigen is positive after 6m of acute infection, the pt is a carrier. |
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Definition
| True, the Hep B surface antigen usually falls away in about 3m 80-90% of cases. |
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Term
True or False The Hep B surface antibody: |
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Definition
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Term
True or False The Hep B core antibody has two parts: - IgG
- IgM
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Definition
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Term
True or False If the Hep B surface antigen is positive the pt is in a highly infectious state. |
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Definition
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Term
| What is the tx for Hep B? |
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Definition
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Term
| What is the post exposure tx for Hep B? |
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Definition
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Term
| Is the treatment for Hep B dependent on the viral load and ALT levels of the pt? |
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Definition
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Term
| What is the most important lab in regard to treating hepatitis? |
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Definition
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Term
| In the pt that has hepatitis, what could the absence, decline, or low level of liver enzymes be an indicator of? |
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Definition
| It may indicate that the liver is damaged to the point that it no longer is able to produce enzymes. |
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Term
| What disease state must be present first in order to diagnose Hep D? |
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Definition
Hep B. If you vaccinate against Hep B, then you really vaccinate against Hep D. |
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Term
True or False We did not test our blood supply for Hep C prior to 1992 |
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Definition
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Term
True or False HIV & Hep C aggrevate one anothers disease states. |
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Definition
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Term
True or False 90% of IVDA have Hep C if > 45y. |
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Definition
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Term
| What is the #1 reason for Liver Transplant? |
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Definition
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Term
| What are some risk factors for Hep C infection? |
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Definition
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Term
| How does the onset of Hep C differ than that of A or B? |
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Definition
| Much slower, insidious onset. |
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Term
| What are some s/s of Hep C? |
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Definition
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Term
| What do most pts with HIV die of today? |
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Definition
| Bleeding complications related to Hep C. If they do not have Hep C, they may live a long life. |
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Term
True or False Liver biopsy is the gold standard for amount of liver damage in hepatitis C, but has risk of bleeding & small risk of death. |
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Definition
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Term
True or False Serial levels of HCV-RNA are crucial in management of Hep C. |
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Definition
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Term
| What is true about HCV-RNA? |
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Definition
Sucessfully treated pts loose HCV-RNA during tx. If HCV-RNA is zero after 6m after tx, cure is durable Cured pts have been followed up to 13y with no return of HCV-RNA
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Term
What population should not be treated for Hep C? |
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Definition
Depressed----suicide Severe heart disease Autoimmune diseases |
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Term
True or false Regarding the tx of Hep C: Interferon is a protein the body makes to fight viral infections. It protects healthy cells & increases immune response. |
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Definition
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Term
True or False Treatment of Hep C is sucessful when no Hep C antibody and no vial load exist. |
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Definition
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Term
True or False In treating Hep C, if HCV-RNA blood levels fall with the first dose of interferon and is zero by one month of tx the pt is curable. |
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Definition
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Term
| What annual labs should be ordered for chronic Hep C pt? |
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Definition
CT liver (or u/s) LFTs PT/PTT Hep C viral load Alpha Feto Protien
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Term
| When a pt with HepC is tx with interferon what are the S/E? |
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Definition
Flulike symptoms NO TYLENOL/NSAIDS/ETOH medicate for discomfort with oxycodone beware of suicide attempts causes fatigue and sleep disturbance.
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Term
| Regarding Hep C, Is it true that Ribavirin is an antiviral drug which cannot eleliminate HCV by itself but when combined with interferon it doubles its efficacy? |
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Definition
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Term
Evalute the following Hep B panel results & explain its meaning to the pt.: Hep B Surface Antigen: Negative Hep B Surface Antibody: Positive Hep B Core Antibody: Negative
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Definition
No acute disease Immunity exists due to vaccination No evidence of past exposure/infection.
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Term
| What are some S/E of Ribravirin? |
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Definition
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Term
True or False In treating Hep C, using the cobonation of Ribavirin and Interferon results in twice the effeciveness. |
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Definition
| True, but ribavirin cannot be used alone. |
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