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Hemostasis
Hard
137
Veterinary Medicine
Undergraduate 2
09/06/2011

Additional Veterinary Medicine Flashcards

 


 

Cards

Term
Which is not a protein involved in the clotting process?
Definition
Ca
Term
What vitamin is necessary for clotting?
Definition
Vitamin K
Term
What factors can impair the clotting process?
Definition
Ca deficiencies, liver disease, low platelet count.
Term
Clotting factor 1
Definition
fibrinogen (produced in liver)
Term
Clotting factor 2
Definition
prothrombin(produced in liver, vitamin K dependent)
Term
Clotting factor 3
Definition
Thromboplastin (present in all tissue)
Term
Clotting factor 4
Definition
Calcium
Term
Clotting factor 5
Definition
Proaccelerin (produced by platelets)
Term
Clotting factor 6
Definition
none
Term
clotting factor 7
Definition
proconvertin (produced by liver, vitamin K dependent)
Term
clotting factor 8
Definition
antihemophilic factor A (produced by vascular endothelium
Term
clotting factor 9
Definition
Christmas Factor (produced in liver vitamin K dependent)
Term
Clotting factor 10
Definition
Stuart-Prower factor
Term
Clotting factor 11
Definition
plasma prothrombin antcedent (produced in liver)
Term
clotting factor 12
Definition
Hageman factor (produced in liver)
Term
Clotting factor 13(the last one)
Definition
fibrin-stabilizing factor(produced in liver)
Term
Intrinsic pathway
Definition
damage to the endothelium or contact between blood and a foreign substance
Term
Extrinsic pathway
Definition
blood contact with extravascular issues
Term
what 13th factor starts the extrinsic pathway?
Definition
Fibrin-stabilizing factor (produced in liver)
Term
what 12th factor starts the intrinsic pathway?
Definition
Hageman factor (produced in liver)
Term
Tell me the combined pathway.
Definition
Factor 10 (Stuart-Prower factor) Prothrombin to thrombin: Fibrinogen to fibrin, added with Ca
Term
When does clot size stop?
Definition
when blood flow washes away thrombin
Term
How do you prevent clots in blood samples?
Definition
anticoagulants( binds to Ca)
Term
Mucosa bleeding time
Definition
normal 1-5 min
Term
coagulation/clotting time tests
Definition
intrinsic + combined
Term
coagulation/clotting time tests
Definition
intrinsic + combined
Term
Lee white method
Definition
cat+dog 3-5min, 1ml per 3 test tubes. warm water bath, tilt ever 30s until clot
Term
activated clotting time
Definition
60-90 seconds normal
Term
PTT ( partial thromboplastin time)
Definition
intrinsic pathway, citrate plasma, freeze.
Term
PT (prothrombin time)
Definition
extrinsic pathway, citrate plasma freeze
Term
PIVKA (proteins induced by vitamin K antagonism or absence)
Definition
Vitamin K deficiency
Term
What vitamin does rat poison effect?
Definition
Vitamin K
Term
FDP (fibrin degradation product test
Definition
Test for DIC
Term
contusion
Definition
bruise
Term
Petechia [image]
Definition
tiny pinpoint spots of hemorrhage on skin or MM's
Term
Ecchymosis [image]
Definition
larger irregualr areas of hemorrhage, change color over time (blueblack-green-yellow)
Term
Purpura [image]
Definition
hemorrhages in larger areas of skin red-purple-greenish-yellow-
Term
Signs of clotting disorders
Definition
petechiae, hematomas, MM bleeding, bleeding into bodily cavities, prolonged bleeding after venipuncture.
Term
Canine blood types?
Definition
There are 7, 1.1 and 1.2 cause the worst reaction.
Term
NO transfusion history =
Definition
NO reaction
Term
Canine transfusion reaction symptoms include ....?
Definition
Hemolysis, Agglutination
Term
Feline blood types..?
Definition
A, B, AB
Term
What feline blood type most common
Definition
type A (1/3 have anti-B Ab's)
Term
This type is more prone to pure breeds?
Definition
Type B ( all have anti-A ab's)
Term
universal recipients for cat blood transfusion
Definition
AB
Term
Rickettsiae
Definition
intracellular parasitic bacteria
Term
Hemobartonella felis [image]
Definition
small, coccoid, rod or ring shaped that stain dark purple. Cause FIA (feline infectious anemia) Tx: antibiotics
Term
Eperythrozoon [image]
Definition
small, coccoid rods or rings on RBC surface. Stain redish purple.
Term
Anaplasma marginale [image]
Definition
similar to howell jolly bodies, often >1 per cell. transmitted by (fleas, ticks, mosquitoes) recovered animals should be slaughtered
Term
Ehrlichia [image]
Definition
intracellular parasite of monocytes and neutrophils, transmitted by the brown dog tick. You will see higher TP. mild neutropenia, thrombocytopenia, and anemia
Term
Babesia [image]
Definition
protozoal parasite, tear dropped, seens in pairs, common in cattle & equine. transmitted by ticks.
Term
Trypanosoma [image]
Definition
flagellated protozoa, transmitted by the Tsetse fly. Causes african sleeping sickness in people.
Term
Heartworm
Definition
bad one has a tapered end.
Term
Decreased production leading to thrombocytopenia
Definition
FIV, FeLV, Erlichiosis, radiation therapy, leukemia, bone cancer
Term
Thrombocytopenia due to destruction
Definition
IMT, snake venom, transfusion reaction, vaccine induced.
Term
Platelet dysfunction
Definition
Von Willebrands, snake venom, renal and liver failure, pancreatitis
Term
Thrombocytosis
Definition
splenectomy, iron deficiency, neoplasia, cortocosteroids
Term
Clotting factor abnormalities
Definition
congenital defects, liver diseases, toxicity, DIC
Term
Signs of rodenticide toxicity
Definition
pale MM, weakness, frank blood in stool, bruising,
Term
Tests for rodenticide poisoning
Definition
PTT & PT
Term
Most common bleeding disorder in Canine, cats, rabbits, swine.
Definition
Von Willebrands Disease. abnormal is <49%
Term
normal clotting mechanisms are exaggerated
Definition
Disseminated Intravascular Coagulation
Term
absence of D-Dimer rules out ______ with 95% confidence
Definition
DIC
Term
Thrombosis
Definition
thromboembolic embolism (loss of blood supply to body part/organ) blood parasites , sepsis
Term
Brain, lungs, hind limbs
Definition
sites of thrombosis
Term
Cytology
Definition
study of cells
Term
acute inflammation
Definition
neutrophils
Term
chronic inflammation
Definition
monocytes
Term
transudate
Definition
fluid substance that has a low protein and cellular content
Term
exudate
Definition
opaque turbid fluid with many cells and high protein content
Term
exudate means
Definition
bacterial infectin, trauma, cancer
Term
transudate means
Definition
heart failure, decreased albumin
Term
CSF fluid
Definition
red top tube
Term
Normal synovial fluid
Definition
clear, not turbid, slight straw color.
Term
Mucin Clot test
Definition
mix w vinegar . if no clot occurs, there is bacteria
Term
abdominocentesis
Definition
hemorrhage may indicate internal bleeding
Term
Air in thorax
Definition
pneumothorax
Term
Blood in thorax
Definition
hemothorax
Term
fluid in thorax
Definition
pyothorax
Term
Hyperplasia
Definition
large nuclei, mult. nuclei
Term
Carcinoma
Definition
huge nuclei
Term
orotracheal approach
Definition
catheter through endotracheal tube
Term
nasotracheal
Definition
through nasal passages
Term
percutaneous
Definition
through skin and trachea, conscious
Term
Proestrus [image]
Definition
heightened follicular activity
Term
estrus [image]
Definition
is or about to ovulate
Term
metestrus [image]
Definition
early corpus luteum development
Term
anestrus [image]
Definition
female is not sexually receptive
Term
Enzyme linked immunoSorbent Assay
Definition
test for specific antigen or antibody
Term
Coombs test
Definition
IMHA
Term
coggins test
Definition
equine infectious anemia
Term
clinical pathology
Definition
using lab methods to diagnose and treat disease
Term
quantitation
Definition
numbers (close to true concentration)
Term
semi quanitation
Definition
estimate (range)
Term
What is the recommended fast time for blood chem tests
Definition
18hr
Term
control result.
Definition
quality control
Term
What are the kidney function tests?
Definition
BUN, Creatinine, Phosphorus, Calcium
Term
BUN
Definition
product of amino acid breakdown in liver, filtered out of bloodfrom kidneys into urine.
Term
whats causes low BUN?
Definition
liver failure, starvation.
Term
What causes high BUN?
Definition
kidneys not filtering properly, high protein diet.
Term
Creatinine
Definition
formed as a result of muscle metabolism, excreted by liver into urine.
Term
What does a High creatinine indicate?
Definition
renal failure, severe kidney damage, use serum to sample.
Term
Calcium (liver)
Definition
bounded to albumin in blood
Term
High calcium accompanies a low..?
Definition
phosphorus
Term
hypercalcemia
Definition
increase in serum calcium
Term
hypocalcemia
Definition
decrease in serum calcium,, aka milk fever in cows
Term
Phosphorus
Definition
amount in serum serves as a reflection for entire body. ATP release and transfer.
Term
hyperphosphatemia
Definition
increase in serum phosphorus, renal failure, rodenticide (vitamin D intoxication)
Term
hypophosphatemia
Definition
decrease in serum phosphorus, rickets( vitamin D deficiency)
Term
Pancreatic tests
Definition
Amylase, Lipase, Trypsin, Glucose
Term
Amylase& Lipase
Definition
Amylase breaks down starches and glycogen
Lipase breaks down fatty acids
Term
Trypsin
Definition
breaks down proteins.
Term
glucose
Definition
result of carbohydrate breakdown
Term
hyperglycemia
Definition
diabetes mellitus, excitement in felines,
Term
hypoglycemia
Definition
reduced intake
Term
Liver function tests
Definition
ALT, AST, Alkaline Phosphatase, Bilirubin, protein assays.
Term
Alanine Aminotransferase (ALT)
Definition
liver enzyme that catalyzes protein breakdown,
Term
increased ALT indicates
Definition
destruction of hepatocytes
Term
Aspartate Aminotranserase
Definition
liver enzyme that catalyzes protein breakdown
Term
major sources of AST
Definition
cells of heart, liver, skeletal muscle, kidney, and pancreas
Term
AP Alkaline phosphatase
Definition
liver enzyme present in tissues such as osteablasts, aof hepatobiliary systemnd cells
Term
Alkaline phosphatse in young animals, and old animals
Definition
young animals, most AP from bone,
older animals, most AP from liver
Term
Bilirubin
Definition
metabolite of hemoglobin removed from plasma by liver.
Term
Total bilirubin =
Definition
direct(after liver action)+indirect(priot to liver action)
Term
Plasma proteins
Definition
Total protein, albumin, globulins, fibrinogen
Term
most commonly elevated protein assays
Definition
globulins, albumin, fibrinogen
Term
Total serum protein
Definition
measures all protein factors except fibrinogen
Term
Total Plasma Protein
Definition
measures all protein factors
Term
Albumin
Definition
any liver disease may result in decreased albumin , transport fatty acids, bilirubin, drugs. osmotic pressure.
Term
Alpha Globulins
Definition
in liver, transport and bind proteins.
Term
beta globulins
Definition
involved in iron transport and fibrin formation
Term
gamma globulins
Definition
result of antibody production and immunity
Term
Blood electrolytes
Definition
cations: Ca++, Na+, K+, Mg++
anions: Cl-, HCO3-
Term
Sodium
Definition
important in pH regulation of urine, major cation,
Term
Potassium
Definition
intracellular cation,
Term
hyperkalemia
Definition
chronic renal failure, malnutrition
Term
hypokalemia
Definition
addisons , acute renal failure,
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