Intrinsic Factors

- name them

Factor 8, 9, 11, 12, and kininogen-prekallikrein complex

Extrinsic factors

- name them

Common pathway

- in order

Factor 10 activated by 9+8 (intrinsic) or 7 (intrinsic)

Factor 10 activates Factor 2 (Thrombin) along with factor 5

Thrombin converts fibrinogen to fibrin

--> also feedback and activates factors 5 and 8

Thrombin

- functions

Functions:

- cleaves fibrinogen to fibrin

- activates factor 13 to stabilize fibrin

- acts on platelets to stimulate aggregation via activation of arachidonic acid release

- activates coagulation inhibitor, protein C

Factors 2, 7, 9, 10, C-protein, S-protein 

--> all hepatic

Protein C

- actions

Action:

- inhibits activation of Factor 5a and 8a

t-PA

- function

Function:

- activates plasmin which dissolves factors 1, 5, 8

Antithrombin-3

- function