Term
| What are the simple precursors to the Porphyrin/Pyrole ring? |
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Definition
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Term
| What is the rate limiting step of the Porphyrin/Pyrole ring formation? What things effect it? |
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Definition
(Step 1) Glycine + Succinyl CoA→ 5-Aminolevulinic acid (5-Aminolevulinic acid synthase) (-)Heme and Hemin (+)Drugs and Metabolites |
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Term
| Which enzymes act in the Mitochondria during Heme formation? |
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Definition
(Step 1) 5-Aminolevulinate (Last 3 steps) Coproporphyrinogen oxidase Protoporphyrinogen oxidase Ferrochelatase |
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Term
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Definition
| Uses NADPH as a cofactor and adds one O to a substrate and one to a water. |
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Term
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Definition
| O2 is added to a substrate. |
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Term
| What is the product of Hemin getting oxidized a couple times? |
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Definition
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Term
| What proteins bind biliruden in the liver cytosol? |
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Definition
Z-Protein: Also binds fatty acids Ligandin: Also called Y protein. Lower capacity but higher affinity than Z. |
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Term
| What are the proteins that bind with free Heme to stop problems? |
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Definition
Hemopexins: In cells. Fast but few of them. Albumin: Plasma. Slow but more of them. Haptoglobin: bing with Methemoglobins. |
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Term
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Definition
oxidized Hemoglobin (hemoglobin(Fe3+)) Haptogoblons bind to them. |
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Term
| What is a characteristic of Jaundice? |
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Definition
Yellow skin. Its a symptom not a disease. Due to excessive Bilirubin in the blood. |
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