Term
| These lymphomas are CD10+ and CD20+ |
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Definition
| Follicular lymphoma and Burkitt's Lymphoma have these two cell surface markers |
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Term
| This leukemia is CD20+ and CD103+ |
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Definition
| Hairy Cell Leukemia has these two cell surface markers |
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Term
| These two leukemias/lymphomas are CD20+ and CD5+ |
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Definition
| SLL/CLL and Mantle Cell lymphoma share these cell surface markers |
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Term
| This NHL almost always has a t(14:18) mutation, leading to the over expession of BCL-2 |
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Definition
| Mutation of Follicular Lymphoma |
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Term
| This NHL is the only one where a direct blood test can be diagnostic. Sx include hypercalcemia, renal failure, anemia, and bone lesions (CRAB). |
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Definition
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Term
| This lymphoma has delicate neoplastic cells, which create 'smudge cells' when put on glass slides |
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Definition
| Diagnostic feature of SLL (if confined to nodes) or CLL (if luekemic phase is present) under the microscope |
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Term
| The most common adult leukemia, a 17p deletion gives the worst prognosis. Results in hypogamaglobulinemia, with 50% of deaths resulting from infection |
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Definition
| This deletion gives the worst prognosis for SLL/CLL, which is CD 5, 20 and 23 + |
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Term
| This CD19, CD20 + lymphoma generally has a mutation in the BCL-6 regulatory region, or a c-MYC mutation. It enjoys spreading to the waldeyer ring (oropharyngeal lymphoid tissue). |
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Definition
| Diffuse Large B-Cell Lymphoma (DLBCL) has these genetic mutations and spreads to this area |
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Term
| The endemic form is associated with EBV and affects the jaw and abdominal visvera |
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Definition
| Endemic Burkitt's lymphoma is associated with this virus and affects these parts of the body |
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Term
| This disease usually has a t(8:14) mutation involving c-MYC and IgH. P53 is often also lost. |
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Definition
| Genetic mutations of Burkitt's Lymphoma |
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Term
| This disease expresses CD10 and CD20 |
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Definition
| Cell surface markers of Burkitt's Lymphoma |
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Term
| This monoclonal AB targets CD20 |
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Definition
| Rituximab targets this cell surface marker |
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Term
| The rouleaux formation is often seen due to high levels of Ab's (also seen in HIV) |
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Definition
| This RBC pattern is often seen in blood smears with Multiple Myeloma |
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Term
| This condition usually has a 13q deletion and defects in the cyclinD genes |
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Definition
| Multiple Myeloma has these genetic insults |
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Term
| Proliferation of these cells depends on cytokines, especially IL-6 and RANKL, which activates osteoclasts |
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Definition
| The plasma cells in Multiple Myeloma depends on these cell signals for growth |
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Term
| The leading cause of death from this plasma cell dyscrasia is infection, followed by renal failure |
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Definition
| Leading causes of death in Multiple Myeloma |
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Term
| These tumor cells secrete IgM, leading to Waldenstrom's Syndrome (causing visual and neurological deficits), also bleeding due to thrombocytopenia |
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Definition
| Affects of high levels of IG secretion in Lymphoplasmacytic lymphoma |
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Term
| This progressive, incurable lymphoma shows inclusions when stained with PAS. Unlike MM, renal failure and amyloidosis are rare, although Ig production is high |
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Definition
| Lymphoplasmacytic lymphoma has these characteristics |
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Term
| This leukemia does not cause lymphadenopathy (the only one!) and the only symptom is usually splenomegaly |
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Definition
| These are symptoms (or lack of) in Hairy Cell Leukemia |
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Term
| Markers of lymphomas of this progenitor cell type include CD2, CD3 and CD5. Also, they are TdT negative. |
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Definition
| These are cell surface markers of T-cell leukemias |
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Term
| Sx of this type of lymphoma include fever, weight loss, night sweats and pruritis (especially Pel-Ebstein fever), as well as normocytic anemia and cervical or supraclivicular lymph nodes. |
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Definition
| Symptoms of Hodgkins Lymphomas in general |
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Term
| This type of lymphoma begins in a discrete group of nodes and spreads in a step-wise fashion. |
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Definition
| Method by which Hodgkins Lymphoma spreads |
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Term
| This is the most common type of Hodgkins Lymphoma, affecting mostly women and generally having Lacunar Cells |
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Definition
| Features of Nodular Sclerosing Hodgkins Lymphoma (one of 3 types of HL, the other two being: Mixed Cellularity and Lymphocyte Predominant) |
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Term
| This type of lymphoma is usually CD15 and CD30+, and Reed-Sternberg cells are common (found in a background of reactive cells) |
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Definition
| Hodgkins Lymphoma, general characteristics |
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Term
| This leukemia is distinguished by the t(9:22) mutation- the BCR-ABL gene, a.k.a the Philadelphia chromosome |
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Definition
| Genetic mutation characteristic of Chronic Myelogenous Leukemia |
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Term
| Imatinib specifically targets this protein |
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Definition
| This drugs targets the BCR-ABL tyrosine kinase created by the t(9:22) mutation of CML. |
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Term
| This condition leads to replacement of the bone marrow with collagen fibrosis, the presence of tear-drop shaped RBCs, splenomegaly, and is often associated with the JAK2 mutation |
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Definition
| Characteristics of myelofibrosis |
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Term
| This condition has a marked increase in platelets, but they are dysfunctional, resulting in bleeding. JAK2 mutation is common. |
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Definition
| Features of Essential Thrombocytopenia (a myeloid neoplasm) |
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Term
| This is a stem cell disorder causing ineffective hematopoiesis and pancytopenia. Ringed sideroblasts are common, as are dimorphic RBCs. 5q deletions and trisomy of chromosome 8 are common. |
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Definition
| Features of Myelodysplastic Syndrome |
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Term
| This condition has increase proliferative drive in the bone marrow, leading to extramedullary hematopoiesis, marrow fibrosis and cytopenias. Usually due to a tyrosine kinase mutation. |
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Definition
| Features of myeloproliferative diseases |
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Term
| This condition has increased granulocyte and megakaryocyte production, and greater than 20% blasts in the marrow. Auer rods are often present. |
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Definition
| Features of Acute Myeloid Leukemia |
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Term
| This is the most common leukemia between ages 0-14 |
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Definition
| Age range of Acute Lymphoblastic Leukemia |
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Term
| The age range of this disease if 15-60 years |
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Definition
| Age range of Acute Myeloid Leukemia |
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Term
| The age range of this disease is 40-59 years |
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Definition
| The age range of Chronic Myeloid Leukemia |
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Term
| The age range of this leukemia is 60+ years |
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Definition
| Age range of CLL (Chronic Lymphocytic Leukemia). Called SLL if confined to the lymph nodes. |
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Term
| This leukemia includes cytogenic changes such as hyperploidy, and stains positive for TdT. It most often affects kids and has a 95% remission rate w/ treatment. CNS manifestations are common. |
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Definition
| Signs of ALL (Acute Lymphoblastic Leukemia/Lymphoma) |
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Term
| This condition causes panmyelosis and is erythropoieten independent (in fact, EPO levels are low). Due to constitutive JAK2 expression. Systemic pruritis, splenomegaly and bleeding are common. |
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Definition
| Characteristics of Polycythemia Vera |
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