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heme/onc pharm MOA
FirstAid 2010
10
Medical
Professional
03/27/2011
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Term
mtx
 Definition
folic acid analog
inhib dihydrofolate reductase
Term
5-fu
 Definition
pyrimidine analog
inhib thymidylate synthase
Term
6-mp, 6-tg
 Definition
purine analog
decr de novo purine synth
Term
ara-c
 Definition
pyrimidine antagonist
inhib DNA polymerase
Term
dactinomycin
 Definition
intercalates in DNA
Term
doxorubicin (adriamycin), daunorubicin
 Definition
free radical intercalate in DNA
Term
bleomycin
 Definition
free radical breaks DNA
Term
cyclophosphamide, ifosfamide
 Definition
covalently crosslink DNA
Term
nitrosoureas - carmustine, lomustine, semustine, streptozocin
 Definition
cross BBB
Term
busulfan
 Definition
alkylates DNA
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