Term
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Definition
| B12 Deficiency- determines cause |
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Term
| Hypersegmented Neutrophil |
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Definition
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Term
|
Definition
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Term
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Definition
Pb poisoning
the Pb impairs ribonuclease dysf(x) (among others) and ribosomes persist in RBCs |
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Term
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Definition
Beta Thalassemia Major
causes sever hemolytic anema |
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Term
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Definition
Alpha Thalassemia w/ four gene deletions four gamma chains in Hb molecules
Incompatible with life |
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Term
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Definition
Hereditary Spherocytosis
RBCs are fragile and burst in hypotonic solution |
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Term
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Definition
G6PD Deficiency
Result of spleen removing Heinz bodies |
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Term
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Definition
| G6PD Deficiency- pts must avoid eating them |
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Term
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Definition
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Term
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Definition
Loss of splenic macrophage f(x)
Post-splenectomy in:
Hereditary Spherocytosis
Sickle Cell Anemia |
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Term
|
Definition
Parvovirus B19 infx in pts w/:
1. Sickle Cell Anemia
2. Hereditary Spherocytosis
3. Paroxismal Nocturnal Hemoglobinuria |
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Term
|
Definition
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Term
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Definition
Sickle Cell Dz
- Vaso-occlusive crisis in lungs presenting w/ fever, cough, CP and pulm infiltrates
- May have fat embolus, pneumonia (S. pneumo, viral, or mycoplasma) |
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Term
| Splenic Infarction/auto-splenectomy |
|
Definition
Sickle Cell pts
Caused by a vaso-occlusive crisis in splenic vessels (no collateral supply) |
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Term
|
Definition
Sickle Cell Dz
5-FU side effect
Dactylitis of the bones of the hands and feet |
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Term
|
Definition
Sickle Cell Dz
Episodes of hypoxia or infarction caused by obstruction of small vessels by sickled RBCs.
Causes acute pain in areas that are involved. |
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Term
|
Definition
Sickle Cell Dz
Children w/ in tact spleens can have massive entrapment of sickle RBCs causing rapid splenic enlargment, hypovolemia, and sometimes shock.
Can be fatal. |
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Term
| "Crew-Cut" Skull; "Hair on End" appearance |
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Definition
Sickle Cell Anemia, thalassemias
Appearance of skull due to erythroid hyperplasia (marrow expansion) |
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Term
|
Definition
"Crew Cut" Skull
Sickle Cell Anemia
Thalassemias |
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Term
|
Definition
| Organophosphates poisoning (pesticides) |
|
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Term
|
Definition
Thalassemias (Dx on PBS)
Sickle Cell Anemia/hemoglobinopathy
Alcoholics |
|
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Term
|
Definition
Target Cells
Sickle Cell Anemia
Thalassemias
Chronic Alcoholism |
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Term
|
Definition
Microangiopathic Anemia
Formed from mechanical damage caused by RBCs passing through a narrowed vessel.
Seen in DIC, TTP/HUS, SLE, malignant HTN.
Intravascular Hemolysis |
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Term
|
Definition
Hodgkin's Lymphoma
CD30+ and CD15+ |
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Term
|
Definition
| Reed-Sternberg Cell's of Hodgkin's Lymphoma |
|
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Term
|
Definition
Burkitt's Lymphoma
Sheets of lymphocytes interspersed w/ non-neoplastic macs |
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Term
|
Definition
| Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL) |
|
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Term
|
Definition
AML (Acute promyelocytic leukemia)
M2 and M3 Subtypes |
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Term
| Tear Drop Erythrocytes/Dacrocytes |
|
Definition
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Term
|
Definition
Multiple Myeloma
Seen in skull and vertebrae |
|
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Term
|
Definition
Birbeck's Granules = Tennis Raquets
Histiocytosis X
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|
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Term
|
Definition
| Histiocytosis X/Langerhans Cell Histiocytosis |
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Term
|
Definition
| Positive in hereditary spherocytosis |
|
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Term
|
Definition
Microangiopathic Anemia
Formed from mechanical damage caused by RBCs passing through a narrowed vessel.
Seen in DIC, TTP/HUS, SLE, malignant HTN.
Intravascular Hemolysis |
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Term
|
Definition
| Hodgkin's Lymphoma- Lymphocytic predominance |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
Multiple Myeloma
Agglutination of RBCs that look like stacked up poker chips on PBS |
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Term
| Pt w/ hemorrhagic cystitis. What drug? |
|
Definition
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|
Term
| White Eye Reflex/Lack of Red Reflex |
|
Definition
| MCC: 1. congenital cataract (can be due to congenital infx- CMV, rubella, etc.) 2. retinoblastoma |
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Term
| Patches over knuckles (Cancer assoc) |
|
Definition
| Goltran's Patches- assoc. w/ dermatomyositis |
|
|
Term
| Sterile Vegetations on mitral valve (cancer assoc) |
|
Definition
Marantic endocarditis (can embolize)
Mucus-secreting colon cancers |
|
|
Term
| AFP as Tumor Marker- What Cancers? |
|
Definition
1. Yolk-Sack tumors/endodermal sinus tumors, certain types of testicular cancer, e.g.
2. Hepatocellular Carcinoma |
|
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Term
|
Definition
sudden appearance of numerous pigmented seborrheic keratoses
Gastric Adenocarcinoma |
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Term
|
Definition
Normocytic Anemia in Chronic Renal Failure
RBCs w/ undulating membrane |
|
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Term
|
Definition
|
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Term
|
Definition
| Howell-Jolly Bodies (G6PD) |
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|
Term
|
Definition
Basophilic Stippling
Pb poisoning |
|
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Term
|
Definition
Pyruvate Kinase Deficiency (PKD)
Thorny projections from RBC membranes b/c of dehydration of the cell |
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Term
|
Definition
| Myeloproliferative d/o: Essential Thrombocythemia |
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Term
|
Definition
Measures activity of Extrinsic P'way (I, II, V, VII and X)
Used to monitor Warfarin Tx |
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Term
| PTT (Partial Thromboplastin Time) |
|
Definition
Measures activity of Intrinsic p'way (I, II, V, VIII, IX, X, XI and XII)
Used to monitor heparin tx |
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Term
|
Definition
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Term
|
Definition
Burr Cells
Due to damage from a deficiency in EPO caused by Chronic Renal Failure |
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Term
|
Definition
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Term
|
Definition
Mild hemolytic anemia
Caused by point mutation in beta globin gene (glu -> lys) |
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|
Term
| Exposure for Lab Technician |
|
Definition
CN poisoning
HA, Flushing, tachypnea, tachycardia, N/V, confusion, weakness |
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Term
|
Definition
Hemophilia (usually A)
Factor VIII deficiency |
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Term
| Drugs with agranulocytosis as Side Effect |
|
Definition
Carbamazepine
Clozapine
PTU/methimazole
requires weekly WBC monitoring |
|
|
Term
|
Definition
Bite Cells and Heinz Bodies (inset)
G6PD deficiency |
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|
Term
|
Definition
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|
Term
| CTX that causes pulmonary fibrosis |
|
Definition
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|
Term
| CTX that causes hemorrhagic cystitis and antidote |
|
Definition
| Cyclophosphamide and mesna |
|
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Term
| CTX that causes CHF-like cardiotoxicity |
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Definition
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|
Term
| CTX that is metabolized by xanthine oxidase |
|
Definition
| 6-MP; be careful if also on allopurinol, but it will incrase the toxicity of 6-MP |
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