Term
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Definition
| earliest hematopoietic progenitor cells. characterized by: 1) self renewal 2)differentiation |
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Term
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Definition
| a classic example of a hematopoietic growth factor; produced by specialized peritubular cells in the kidney; amount produced is based on the delivery of oxygen to the cells; decreased oxygen = increased EPO |
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Term
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Definition
yolk sac --> liver and spleen --> bone marrow (only site after birth)
with increasing age, decreases in long bones of extremities first |
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Term
| indications for bone marrow examination |
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Definition
| anemia, neutropenia, or thrombocytopenia; leukemia; metastatic neoplasms; selected infectious diseases |
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Term
| tests on bone marrow aspirate |
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Definition
marrow cellularity estimate (biopsy is better);
myeloid: erythroid ration (normally 3:1)
maturation of all hematopoietic lineages
evaluation of "low frequency" elements (i.e. plasma cells, lymphocytes, histiocytes)
iron stores
foreign cells (biopsy may be better for some)
microorganisms |
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Term
| tests on bone marrow core biopsy |
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Definition
cellularity
general maturation of hematopoietic lineages (aspirate is better for detailed examination)
fibrosis (core biopsy specimen only)
foreign cells
granulomas (biopsy only)
microorganisms
bone morphology |
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Term
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Definition
| a reduction in the total circulating red blood cell mass, which results in a reduction in the oxygen carrying capacity of the blood |
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Term
| variables affecting CBC values |
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Definition
| men > women; newborns > school-age; high altitude living increases EPO; prolonged bed rest decreases values; stress or extreme exercise increases; dehydration increases; overhydration decreases |
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