Term
| X-linked recessive d/o commonly seen in American black males & some Mediterranean populations |
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Definition
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Term
| Causes of G6PD deficiency |
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Definition
- oxidative drugs (ASA, dapsone, primaquine, quinidine, sulfonamides, macrobid)
- fava bean ingestion
- infection
cause episodic hemolysis |
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Term
| Severe G6PD deficiency can cause... |
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Definition
| chronic hemolysis (instead of episodic) |
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Term
| G6PD deficiency: patients with episodic hemolysis usually are... |
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Definition
healthy an have no splenomegaly
female carriers rarely are affected |
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Term
| Laboratory findings G6PD deficiency |
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Definition
- during hemolytic episodes, retics, & serum indirect bili increase
- PBS reveals bite cells & heinz bodies (denatured Hgb)
- G6PD levels will be low between hemolytic episodes
- in severe cases G6PD levels will always be low
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Term
| Treatment of G6PD deficiency |
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Definition
- hemolytic episodes are self-limited as red cells are replaced as soon as the offending agent is stopped
- oxidative drugs and fava beans should be avoided
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