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Veterinary Hematology
Professor Sloan Vet117L
53
Veterinary Medicine
Undergraduate 1
01/11/2011

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Term
Erythrocyte
Definition
A mature red blood cell.
Term
Erythropoiesis
Definition
The production of red blood cells.
Term
Buffy coat
Definition
A layer of white blood cells and platelets that collects immediately above the red blood cells in centrifuged whole blood, it has a whitish appearance.
Term
Heinz body
Definition
A rounded, often refractile, projection from the surface of the red blood cell that is a result of oxidation and denaturation of hemoglobin.
Term
Howell-Jolly body
Definition
A small piece of remnant nuclear material in the red blood cell.
Term
Anemia
Definition
A condition in which the hemoglobin, packed cell volume, and red blood cell count decrease below the normal reference range.
Term
Basophilic stippling
Definition
The presence of very small, dark blue staining bodies within the the red blood cell. The stippling is usually a result of RNA accumulation but may be associated with iron accumulation .
Term
Hematocrit
Definition
The percentage of red blood cells relative to plasma.
Term
Lymphocyte
Definition
A white blood cell of the agranulocytic lineage that is characterized by a round nucleus and light blue cytoplasm.
Term
Keratocyte
Definition
A red blood cell with two fairly uniform hornlike projections.
Term
Ghost cell
Definition
A remnant membrane of a red blood cell.
Term
Anisocytosis
Definition
A variation in the size of cell; in hematology, this is most often used to describe variation in the size of red blood cells.
Term
Agglutination
Definition
Clumping of red blood cells that is usually caused by cross-linking of red blood cell surface-associated antibodies.
Term
What is the normal reference range for TPP (Total Plasma Protein) for dogs and cats ?
Definition
5.5 g/dl - 7.5 g/dl
Term
What could increased TPP indicate ?
Definition
Hemoconcentration or increased globulin production.
Term
Where are red blood cells produced ?
Definition
Bone marrow
Term
Macrocytes
Definition
large red cells
Term
Microcytes
Definition
small red cells
Term
What is a CBC ?
Definition
Complete blood count
Term
What is the anticoagulant of choice for most hematology ?
Definition
EDTA
Term
Red cells show increased susceptibility to lysis after _____ hours in EDTA .
Definition
24
Term
What tubes are recommended for platelet and coagulation studies?
Definition
Sodium citrate
Term
What is the major source of error in centrifuging the microhematocrit?
Definition
Trying the save time by not allowing the sample to spin the full amount of time.
Term
What stimulates the production of bone marrow?
Definition
Kidney
Term
Erythropoietin does not stimulate ___ ___ ____ production
Definition
White blood cell
Term
The average red blood cell circulates in dogs for _____ days.
Definition
100
Term
The average red blood cell circulates in cats for _____ days.
Definition
85-90 .
Term
Why is cat hemoglobin more susceptible to oxidation than dog hemoglobin ?
Definition
It contains a high percentage of sulfur-containing amino acids which are easily oxidized.
Term
Definition of Hypochromasia ?
Definition
Decreased hemoglobin concentration .
Term
What is the most common artifactual change see in blood films?
Definition
Crenation
Term
Definition of crenation ?
Definition
The presence of red cells covered by short spiky surface projections .
Term
Platelet counts performed more than _____
hours after collection are suspect
Definition
4-6
Term
T or F - If a delay is anticipated before processing blood , it should be left at room temperature.
Definition
False
Term
Scanning a blood smear at low magnification can give you what information?
Definition
rouleaux formation,
RBC, WBC or platelet aggregation.
Term
What is the most common artifactual change seen in blood films?
Definition
crenation
Term
Anemia
Definition
Decreased red cell mass.
Term
How are anemias classified ?
Definition
Regenerative or nonregenerative
Term
Neutrophils
Definition
The primary defense against invasion of tissues by microorganisms. They kill bacteria and can damage or participate in the destruction of mycotic agaents, algae, and viruses.
Term
Neutropenia
Definition
A decrease in the absolute number of neutrophils.
Term
Eosinophils
Definition
Participate as a major component of systemic hypersensitivity reactions.
Term
Monocytosis
Definition
Increased numbers of circulating monocytes.
Term
T or F - Platelets are essential for normal hemostasis
Definition
True
Term
Thrombocytopenia
Definition
Decreased platelet count
Term
Petechiae
Definition
A red or purple spot on the body caused by a minor hemmorhage ( broken capillary blood vessels.)
Term
The clinical hallmark of petechiae is ?
Definition
Thrombocytopenia
Term
These are the most common white blood cell found in the peripheral blood of all common domestic species except ruminants
Definition
Segmented neutrophil
Term
Rouleaux
Definition
Linear arrays of red blood cells stacked one on top of another.
Term
Agglutination
Definition
Unorganized three-dimensional clustering of red blood cells, typically formed as a result of cross-linking of red blood surface-associated antibodies.
Term
Ghost cells
Definition
Remnant membranes of red blood cells that undergone intravascular lysis.
Term
Eccentrocyte
Definition
Crescent-shaped clear areas that are eccentrically placed. The clear area is where cell membranes are closely apposed and possibly bonded as a result of oxidant-induced membrane damage.
Term
True or False - Bacteria have a nucleus .
Definition
False - Bacteria are anucleated.
Term
True or False - Thrombocytes have a nucleus.
Definition
False - Thrombocytes are anucleated.
Term
True or False - Thrombocytes are 1/4 the size of erythrocytes.
Definition
True - They are small cell fragments.
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