Term
| Periperal Zone components |
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Definition
| Glycocalyx, pm, membrane lipids and proteins, Glycoproteins IIb/IIIa |
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Term
| What are the plasma proteins in the glycocalyx/surface layer of the peripheral zone? |
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Definition
| factor 5, von willebrand factor, fibrinogen |
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Term
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Definition
| a coagulation factor that makes fibrin form |
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Term
| What is von willebrand factor? |
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Definition
| it mediates the attachment of proteins |
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Term
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Definition
| It is and integral protein and a receptor for von willebrand factor. it also binds ristocetin and thrombin and associates with actin on the inner leaflet of the membrane |
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Term
| what is glycoproteins IIb/IIIa? |
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Definition
| receptor after activation that binds fibrin and is required for platelet aggregation to form a plug. |
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Term
| what does the structural zone consist of and what is it's purpose? |
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Definition
| to maintain the discoid shape. it consists of a microtubule and protein network |
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Term
| What does the membrane system consist of? |
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Definition
Open canicular system and dense tubular system |
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Term
Describe: the open canicular system |
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Definition
| cannals that allow granules to exit that functions in storage and secretion. Is derived from the surface of the promegakaryocyte. |
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Term
| Describe: the Dense Tubular system |
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Definition
| it helps actin polymerize and originates from the smooth ER of the promegakaryocyte's. It is the storage site of calcium |
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Term
What are the steps of repair of vessel injury? |
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Definition
1. Vasoconstriction/ Adhesion 2. Activation/shape change 3. Aggregation of platelets 4. Secretion 5. Plug Formation 6. stabilization of the clot |
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Term
| Explain how the shape of platelets changes after activation(adhesion) and the significance of the change? |
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Definition
actin the polymerized and change shape of the platelet by forming pseudopods. The arm growth is to hang onto other platelets to form a cohesive clot. |
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Term
How does aggregation of platelets occur? |
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Definition
a few seconds after vessel infury the platelets are stabilized by internaland external fibrinogen (fibrin strands). ----->fibrin platelet plug forms |
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Term
| What is plasminogen converted to plasmin by in the fibrinolytic pathway? |
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Definition
High molecular weight kininogens kallikrein protein C (which is activated by protein S) |
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Term
| What does Plasmin deactivate or degrade? |
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Definition
Fibrin activated Factor 12 activated Factor 8 activated Factor 5 |
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Term
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Definition
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Term
| What are the 5 important pathway of glucose metabolism? |
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Definition
1. Embden-Meyerhof PW 2. Hexose Monophosphate PW 3. Methemoglobin Reductase PW 4. Rapaport-Leubering PW 5. Pyruvate Kinase |
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Term
| What is the purpose of the HEXOSE MONOPHOSPHATE PW? |
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Definition
| It uses G-6-PD to made NADPH which helps with redox reactions to bring hemoglobin from an oxidized state back to a reduced state so disulfide bridges don't fall apart. |
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Term
| What is the purpose of the METHEMOGLOBIN REDUCTASE PW? |
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Definition
| Hemoglobin reversal where methyl groups that were attached to hemoglobin from oxygen damage are taken off. |
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Term
| What is the purpose of the RAPAPORT-LUEBERING PW? |
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Definition
To produce 2,3-BPG which stabilized hemoglobin when it's not bound to oxygen making it easier for hemoglobin to give up oxygen in active tissues. |
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Term
| Why do we want to draw venous blood? |
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Definition
| easy to collect, not painful, damage to a vein isn't very traumatic |
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Term
| what three veins in the arm are commonly used to take blood? |
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Definition
1. median cubital--middle 2. cephalic---thumb side of hand 3. bascilic--inside of arm |
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Term
| What is the Wright Stain composed of? |
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Definition
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Term
| What do B-lymphocytes do? |
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Definition
present antigens for old agents and make antibodies, plasma cells |
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Term
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Definition
| they direct immune response |
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Term
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Definition
| they are precursors to dendritic cell (an antibody presenting cell in tissues) or are precursors to macrophages (antigen presenting cell) |
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Term
| What enzymes do neutrophils contain in their granules? |
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Definition
| lysozyme, lactoferrin, myeloperoxidase, collagenase, plasminogen, protease |
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Term
| What do eosinophils contain what do they do, and what color do they look, why? |
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Definition
peroxidases that are basic so they look red Kill Helminth Parasites |
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Term
| What do basophils do and what's in their granules? |
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Definition
| mediate allergic response, hitamine |
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Term
| What causes pluripotent sc to mature into specific cell types? |
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Definition
| Colony Stimulating Factors |
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Term
| At what stage do myeloid cells commit to a specific granulocyte? |
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Definition
| at myelocytes---bc they have secondary granules |
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Term
| How long do Neutrophils live? |
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Definition
| 9-10 days from blast to death |
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Term
Life span of Eosinophils? |
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Definition
| stored in BM for several days ----> t(0.5)=18 hours ---->6 days in tissues |
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