Term
|
Definition
Bell-shaped; Mexican hats
Appears very thin and flat on smear
Bull’s Eye
Represents a rearrangement of hemoglobin
Excessive cell membrane stains dark
Clear ring
Hemoglobin |
|
|
Term
| 2 Reasons for Target Cell Development |
|
Definition
Increased cell membrane and surface area
-Due to lipid alteration
-Cells expand with increased surface area
Decreased hemoglobin
-Hemoglobin synthesis is altered |
|
|
Term
| Target Cell - Hemoglobinopathies |
|
Definition
Sickle cell anemia
Hemoglobin C disease
Thalassemia |
|
|
Term
| Target Cell - Disorders causing an increase in membrane lipids |
|
Definition
|
|
Term
| Target Cell - Hemoglobin synthesis is altered |
|
Definition
Thalassemia
Severe cases of iron deficiency anemia |
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Term
|
Definition
Cup-shaped
Reversible condition
Often an artifact
Central pallor is slit-shaped, mouth-shaped or rectangular |
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|
Term
| Stomatocytes may be observed in (3): |
|
Definition
Electrolyte imbalance
(Increased sodium; decreased potassium)
Alcoholism
Lipid alteration of membrane |
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|
Term
True or False:
Whenever inclusion bodies are present in RBCs, this indicates disease/condition |
|
Definition
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|
Term
|
Definition
Remnants of nuclear material (DNA)
Occurs during mitosis
Small deep blue, round granules
Usually one dark inclusion at periphery of cell |
|
|
Term
| Howell-Jolly Bodies may be due to (2): |
|
Definition
Accelerated or abnormal erythropoiesis
Spleen not removing (pitting) piece of nucleus |
|
|
Term
| What is the Most Common Reason for Howell-Jolly Bodies? |
|
Definition
|
|
Term
| Howell-Jolly Bodies may be observed in (5) |
|
Definition
Megaloblastic anemia
---B12 and Folic acid deficiency
---Faulty maturation of RBC precursors
Splenomegaly or splenectomy
Thalassemia
Sickle Cell Anemia
Hemolytic Anemia |
|
|
Term
|
Definition
Aggregates or clumped ribosomes containing RNA (denatured RNA)
Indicates altered or impaired hemoglobin synthesis
Granules are distributed throughout the RBC
Fine or coarse |
|
|
Term
Will the following have fine or coarse granules in basophilic stippling?
Lead Poisoning |
|
Definition
|
|
Term
Will the following have fine or coarse granules in basophilic stippling?
Thalassemia |
|
Definition
|
|
Term
| Pappenheimer Bodies (Siderocytes) |
|
Definition
-Collection of mitochondria and ribosomes that contain iron
-Contain non-heme iron (Fe++) that was not utilized in hemoglobin production
Ineffective iron metabolism |
|
|
Term
| Do you stain Pappenheimer Bodies with BOTH Romanowsky (Wwright-Giemsa) AND PerI's (Prussian Blue or Iron Stain)? |
|
Definition
|
|
Term
| What is Prussian Blue or Iron Stain used for when it comes to Pappenheimer Bodies? |
|
Definition
|
|
Term
| What will be the appearance of Pappenheimer Bodies with the Wright Stain? |
|
Definition
Subtle pale dots near periphery of cell
Doublets and triplets |
|
|
Term
| What are Pappenheimer Bodies observed in: |
|
Definition
Sideroblastic anemia
--Iron overload
--Overabundance of iron metabolism causing iron to be stored in other places besides liver and BM
Thalassemia (altered hemoglobin production)
Splenectomy |
|
|
Term
True or False:
One must confirm Pappenheimer Bodies with Prussian Blue stain |
|
Definition
|
|
Term
| When you use a Prussian Blue stain for Pappenheimer Bodies what will you call them? |
|
Definition
|
|
Term
| What type of stain do you use for Heinz Bodies? |
|
Definition
|
|
Term
The following are examples of what type of stain?
Crystal Violet
New Methylene Blue |
|
Definition
|
|
Term
|
Definition
Composed of denatured or precipitated hemoglobin
Large, round masses lying under or attached to the cell membrane |
|
|
Term
| Will you observe Heinz Bodies on a Wright Stain? |
|
Definition
|
|
Term
| What are Heinz Bodies Observed in? |
|
Definition
G6Pd deficiency
unstable hemoglobin
--causes Iron to be unprotected
Oxidizing drugs
Alpha Thalassemia |
|
|
Term
|
Definition
Ring or figure 8 forms
Contain arginine-rich histone and non-hemoglobin iron
Thought to be remnants of spindle fibers, which form during mitosis |
|
|
Term
| Cabot Rings may be observed in (2): |
|
Definition
Severe anemias; Pernicious Anemia
Dyserythropoiesis |
|
|
Term
|
Definition
Oblong dark crystals in RBCs
Abnormal hemoglobin crystallizes
Not normally present in Normal Adult Blood |
|
|
Term
| What are Hemoglobin C Crystals Diagnostic for? |
|
Definition
|
|
Term
True or False:
Stages observed on the slide are dependent on the type of malaria the patient has |
|
Definition
|
|
Term
| Is malaria clinically significant even if only one is seen? |
|
Definition
|
|
Term
|
Definition
Usually a metarubricyte
Always abnormal in adult peripheral blood
Few are normally observed in newborn blood (2-24) |
|
|
Term
| What 2 situations may cause RBCs to clump? |
|
Definition
|
|
Term
|
Definition
Random clumping of RBCs
Usually due to a cold antibody |
|
|
Term
| At what temperature will IgG antibodies stop agglutinating? |
|
Definition
|
|
Term
| At what temperature will IgM antibodies agglutinate? |
|
Definition
|
|
Term
| What should you do if Agglutination is seen? |
|
Definition
| Warm the specimen to 37 degrees Celsius to disperse the agglutination |
|
|
Term
What problems does Agglutination cause for instrument counting:
MCV
RBC Count |
|
Definition
|
|
Term
|
Definition
Red blood cells look like stacks of coins
Due to elevated antibodies (globulins) or improper balance of proteins |
|
|
Term
| What 3 conditions is Rouleaux observed in: |
|
Definition
Multiple Myeloma
Liver disease
Chronic inflammation |
|
|
Term
Are the following Diagnostic in Few Numbers:
Sickle cells
C crystals |
|
Definition
|
|
Term
Are the following Diagnostic in Few Numbers:
Schistocytes
Malaria/other blood parasites
Target cells if anemia is present |
|
Definition
|
|
Term
Are the following Diagnostic in Few Numbers:
Tear drop cells in some settings
Spherocytes in some settings |
|
Definition
|
|
Term
| How many fields should you look at when evaluating a blood smear? |
|
Definition
|
|
Term
| Should you correlate your findings to CBC results and clinical condition |
|
Definition
|
|
Term
In What Cell Type Will you find the following:
No Granules |
|
Definition
Blast
Any Erythrocyte Stage |
|
|
Term
In What Cell Type Will you find the following:
Primary Granules |
|
Definition
|
|
Term
In What Cell Type Will you find the following:
Secondary Granules |
|
Definition
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