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Hematology Lecture 1
Hematology Lecture 1 Introduction and Hematopoiesis
70
Biology
Undergraduate 3
11/26/2014

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Term
Hematology
Definition
The study of blood cell production, destruction, number, and disease
Term
Most common specimen for Hematology is _____
Definition
blood
Term
EDTA, Heparin, and sodium citrate are all types of
Definition
Anticoagulants
Term
2 Types of normal blood cells
Definition
Red Blood cells
Platelets
Term
3 Components of WBCs
Definition
Lymphocytes
Monocytes
Granulocytes
Term
4 Types of Granulocytes
Definition
Eosinophils
Basophils
Segmented Neutrophils
Band Neutrophils
Term
What does the following mean:
-emia
Definition
in the blood
Term
What does the following mean:
-cytosis
Definition
Increased number of cells
Term
What does the following mean:
-cytopenia
Definition
Decreased number of cells
Term
What does the following mean:
-medullary
Definition
bone marrow
Term
What does the following mean:
-opathy
Definition
Disease
Term
What does the following mean:
-megaly
Definition
Enlarged
Term
What does the following mean:
-myeloid
Definition
White blood cell
Term
What does the following mean:
-meta
Definition
Change
Term
What does the following mean:
-heme
Definition
Blood
Term
What does the following mean:
-philia
Definition
Increased number of or love of
Term
What does the following mean:
-intravascular
Definition
inside the vessel
Term
What does the following mean:
-extravascular
Definition
outside of vessel
Term
What does the following mean:
-hypo
Definition
Decrease
Term
What does the following mean:
-hyper
Definition
Increase
Term
What does the following mean:
-plasia
Definition
Formation
Term
What does the following mean:
-poly
Definition
Many
Term
What does the following mean:
-erythroid
Definition
Red blood cell
Term
What does the following mean:
-lysis
Definition
Break up
Term
CBC includes:
Definition
WBC
RBC
Plt count
Hgb
Hct
Indices
White cell differential
Term
What does MCV indicate?
Definition
RBC size
Term
What does MCH indicate?
Definition
Weight of hemoglobin contained in RBC
Term
What does MCHC indicate?
Definition
Average concentration of hemoglobin in RBC
Term
MCH, MCHC - ______ in microcytic anemia
Definition
Decreased
Term
MCH, MCHC - ______ in macrocytic anemia
Definition
Increased
Term
Network of cells and tissues in spleen, liver, thymus, bone marrow, and lymph nodes
Network is involved in formation and destruction of blood cells, metabolism of iron, inflammation, and immunity
Definition
Reticuloendothelial System
Term
T or F:
RES is cell and tissue specific
Definition
True
Term
What does the RES provide to fight infection, carry oxygen, and prevent bleeding
Definition
Cells
Term
What is the largest organ IN the body
Definition
Bone Marrow
Term
____ ____ is located within the cavities of the cortical bones and consists of two types
Definition
Bone Marrow
Term
Which type of marrow is:
hematopoietically active
Definition
Red Marrow
Term
Which type of marrow is:
hematopoietically inactive and composed primarily of adipocytes
Definition
Yellow Marrow
Term
During infancy and early childhood, bone marrow is most ____ ____ marrow
Definition
Red Active
Term
At what age does Retrogression begin to occur?
Definition
Seven
Term
Which type of marrow is restricted to flat bones, sternum, vertebrae, pelvis, ribs, skull, and proximal long bones
Definition
Red Marrow
Term
True or False:
By adulthood, marrow is 50% blood cells and 50% fat
Definition
True
Term
Blood is supplied by the ______ arteries that coil around the central vein, passing along the bone canal
Definition
periosteal
Term
Red Marrow is composed of _________ cords that contain all of the developing blood cell lineages, stem and progenitor cells, adventitial cells, and macrophages
Definition
extravascular
Term
______ are calcified bone and help to support cells in a semi-liquid cord
Definition
Trabeculae
Term
______ develop in small cluster adjacent to the outer surfaces of the vascular sinuses
Definition
RBCs
Term
________ develop close to the vascular walls
Definition
Megakaryocytes
Term
______ develop deep in the cord and migrate closer to the vascular sinuses
Definition
Granulocytes
Term
____ _____ will also surround macrophages carrying iron to incorporate iron into hemoglobin
Definition
RBC blasts
Term
Lymph Nodes
Definition
Encapsulated collection of lymphocytes, plasma cells, and macrophages
Term
3 Main functions of the Lymph Nodes
Definition
*Play a role in the formation of new lymphocytes from the germinal centers

*Involved in the processing of specific immunoglobulins (antibodies)

*Involved in the filtration of particulate matter, debris, and bacteria
Term
What is the largest lymphoid organ in the body
Definition
Spleen
Term
The spleen functions as an:
Definition
Indiscriminate filter of the circulating blood
Term
Spleen contains about _____ mL of blood
Definition
350
Term
White Pulp of the Spleen consists of mostly
Definition
B lymphocytes
Term
_____ is a filter lined with specialized macrophages that help remove red cells incapable of exhibiting “deformability”
Definition
Sinus
Term
5 Functions of the Spleen
Definition
*Involved in immunity

*Sort, alter, modify red cells

*Remove old or damaged red cells – process called culling

*In some cases will develop hematopoiesis

*Holding area for 30% of platelet population in peripheral blood
Term
When the Spleen develops hematopoiesis what is this referred to as?
Definition
extramedullary hematopoiesis
Term
T or F:
Babies have twice as many RBCs as do adults
Definition
True
Term
Which cell can become any cell, depending on the stimulus received by the cell?
Definition
Pluripotential Stem Cell
Term
T or F:
Pluripotential stem cells can replicated by mitosis or can proliferate into another cell
Definition
True
Term
True or False:
Pluripotential stem cells are capable to self-renewal
Definition
True
Term
What does CFU stand for?
Definition
Colony Forming Unit
Term
What does CSF stand for?
Definition
Colony Stimulation Factor
Term
True or False:
Multipotential stem cells or progenitor cells commit to only one cell line
Definition
True
Term
The granulocyte blasts represent cells that have limited ______-______
Definition
self-renewal
Term
True or False:
As cells proliferate, they cease to reproduce
Definition
Term
True or False:
Stem Cells will continue with the proliferation and maturation stages until cell maturity is reached
Definition
True
Term
True or False:
All stem/progenitor cells look very similar and cannot be distinguished by appearance
Definition
True
Term
Erythropoietin is produced in the kidney in response to what?
Definition
Blood Oxygen Tension
Term
______ ______ include the colony-forming units, colony stimulating factors, and erythropoietin
Definition
Growth Factors
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