Term
| Protein S is a cofactor for what other protein? |
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Definition
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Term
Given the etiology, Name the Coagulation Disorder:
Protein C binds to activated factors V & VIII and STOPS CLOTTING. |
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Definition
| Protein C or S Deficiency |
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Term
| Protein C acts as a natural _________. |
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Definition
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Term
| Is a Protein C or S Deficiency generally acquired or genetic? |
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Definition
| Genetic, but are Vitamin K Dependent. |
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Term
True or False:
Both protein S and C are Vitamin K dependent so they CAN'T be assayed until 2 weeks after stopping Coumadin (since Coumadin has an affect on Vitamin K) |
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Definition
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Term
Which coagulation disorder is associated with the following clinical presentation:
Associated with life-long blood clots that can be fatal |
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Definition
| Protein C or S Deficiency |
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Term
| Patients that have been diagnosed as have a Protein C or S Deficiency are put on what type of medication? |
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Definition
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Term
| What is another name for Activated Protein C Resistance? |
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Definition
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Term
Given the etiology, Name the Coagulation Disorder:
Without the ability to inhibit activated factors V & VIII, clots form. |
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Definition
| Activated Protein C Resistance / Factor V Leiden Mutation |
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Term
| Is Activated Protein C Resistance / Factor V Leiden Mutation Acquired or Genetic? |
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Definition
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Term
True or False:
Clot-based tests can be used to diagnose Activated Protein C Resistance / Factor V Leiden Mutation |
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Definition
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Term
| What is the definitive test to diagnose Activated Protein C Resistance / Factor V Leiden Mutation? |
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Definition
| Molecular procedure to detect the gene mutation |
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Term
Given the Clinical description, name the coagulation disorder associated with it:
INCREASED Tendency to have EXCESS Clot Formation |
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Definition
| Activated Protein C Resistance / Factor V Leiden Mutation |
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Term
| What is the MOST COMMON Genetic Thrombophilia? |
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Definition
| Activated Protein C Resistance / Factor V Leiden Mutation |
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Term
Given the etiology, name the Coagulation Disorder:
Antithrombin neutralizes factor Xa and Thrombin to protect against excess clotting. Process accelerated by Heparin. |
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Definition
Antithrombin (AT) Deficiency
-Formerly called "ATIII" |
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Term
| If a patient is Antithrombin Deficient, what will the patient form? |
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Definition
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Term
True or False:
AT Deficiency can be Genetic OR Acquired in DIC, Liver Disease, and Woman on Oral Contraceptives |
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Definition
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Term
| What is the Test to Diagnose AT Deficiency? |
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Definition
| Plasma is Mixed with a Known Excess of Thrombin or Xa in the presence of Heparin. Amount of thrombin left after neutralization inversely proportional to AT. |
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Term
| What is AT Deficiency often suspected? |
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Definition
| When a patient's PTT does NOT rise as expected after NORMAL dosing with Heparin following a clot. |
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Term
Given the clinical description, name the Coagulation Disorder:
Thrombosis |
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Definition
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Term
True or False:
Since Heparin works by binding to Antithrombin (AT), MORE Heparin must be given for clots to form since AT will be deficient. |
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Definition
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Term
Given the etiology, name the Coagulation Disorder:
Autoantibody to platelets causes INCREASED destruction by the spleen |
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Definition
| Immune/Idiopathic Thrombocytopenic Purpura (ITP) |
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Term
| Is ITP acquired or genetic? |
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Definition
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Term
| In whom are Acute cases of ITP seen? |
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Definition
| Children after an infection |
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Term
| In whom are Chronic cases of ITP seen? |
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Definition
Young Women
-can be longer lasting |
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Term
Given the following test results, name the Coagulation Disorder associated with the results:
VERY DECREASED Platelet Count
Rest of CBC NORMAL
PAIgG (anti platelet antibody) is POSITIVE |
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Definition
| Immune/Idiopathic Thrombocytopenic Purpura (ITP) |
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Term
True or False:
Bruising is a clinical sign that is often associated with ITP |
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Definition
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Term
| How would/should you treat ITP? |
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Definition
| Steroides if spontaneous remission does not occur. |
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Term
True or False:
You can also use IV immunoglobulin, RhIG, or perform a splenectomy to treat ITP. |
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Definition
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Term
Given the etiology, Name the Coagulation Disorder:
HPA-1a platelet antibody in mother passes to fetus causing DECREASED Platelets |
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Definition
| Neonatal Alloimmune Thrombocytopenia (NAIT) |
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Term
| Is Neonatal Alloimmune Thrombocytopenia (NAIT) Acquired or Genetic? |
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Definition
| The Mother typically develops the antibody after previous pregnancy or transfusion. (Acquired) |
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Term
True or False:
In Neonatal Alloimmune Thrombocytopenia (NAIT), the infant's Platelet count is LOW at Birth |
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Definition
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Term
| If bleeding occurs in the brain with an infant having Neonatal Alloimmune Thrombocytopenia (NAIT) what can occur? |
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Definition
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Term
| The mechanism of Neonatal Alloimmune Thrombocytopenia (NAIT) is similar to HDN. How is it different? |
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Definition
| Mechanism is with platelets (plts) rather than red blood cells (RBCs) |
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