Term
Given the Principle, Name the Coagulation Test:
Plasma mixed with rabbit thromboplastin (Factor III) containing Ca+2; Time to form clot is measured by light sensing or mechanical methods |
|
Definition
| Prothrombin Time (Also Called Protime or PT) |
|
|
Term
Given the Principle, Name the Coagulation Test:
Patient plasma mixed with commercial phospholipid substitute and activator of factor XII (actin) plus Ca+2. Time to clot measured by light or mechanical methods |
|
Definition
| PTT or APTT (A.K.A. Activated Partial Thromboplastin Time) |
|
|
Term
Given the Principle, Name the Coagulation Test:
Patient plasma mixed with thrombin. Time to clot is measured. |
|
Definition
| Thrombin Time (TT) or Thrombin Clotting Time |
|
|
Term
Given the Principle, Name the Coagulation Test:
This snake venom converts fibrinogen to fibrin without thrombin |
|
Definition
| Reptilase Time (Variant of the TT) |
|
|
Term
| What is the reference range for PT? |
|
Definition
9-12.5 seconds
*All reference ranges vary by lab and reagents used |
|
|
Term
| What is the reference range for PTT/APTT? |
|
Definition
20-35 seconds
*Therapeutic about 1.5-2 times patient's baseline |
|
|
Term
| What is the reference range for TT & is also the reference range for Reptilase Time? |
|
Definition
|
|
Term
Given the reference range, what is the Coagulation test associated with it?
9-12.5 seconds
*All reference ranges vary by lab and reagents used |
|
Definition
|
|
Term
Given the reference range, what is the Coagulation test associated with it?
20-35 seconds
*Therapeutic about 1.5-2 times patient's baseline |
|
Definition
|
|
Term
Given the reference range, what is the Coagulation test associated with it?
Less than 20 seconds |
|
Definition
|
|
Term
What factors are measured by the following coagulation tests:
PT |
|
Definition
|
|
Term
What factors are measured by the following coagulation tests:
PTT |
|
Definition
| Measures all factors EXCEPT VII & XIII |
|
|
Term
What factors are measured by the following coagulation tests:
Thrombin Time (TT) |
|
Definition
| Measures only the conversion of fibrinogen to fibrin |
|
|
Term
What factors are measured by the following coagulation tests:
Reptilase Time |
|
Definition
| Measures only the conversion of fibrinogen to fibrin but is NOT affected by heparin |
|
|
Term
Name the test that measures the following factors:
I, II, V, VII, X |
|
Definition
|
|
Term
Name the test that measures the following factors:
Measures all factors EXCEPT VII & XIII |
|
Definition
|
|
Term
Name the test that measures the following factors:
Measures only the conversion of fibrinogen to fibrin |
|
Definition
|
|
Term
Name the test that measures the following factors:
Measures only the conversion of fibrinogen to fibrin but is NOT affected by heparin |
|
Definition
|
|
Term
Given the Disease(s) Detected, What is the Coagulation Test associated with it/them:
Coumadin therapy; liver disease; Vitamin K deficiency; DIC; EXTRINSIC factor deficiencies |
|
Definition
|
|
Term
Given the Disease(s) Detected, What is the Coagulation Test associated with it/them:
INTRINSIC factor deficiencies, monitor heparin, DIC, Circulatin anticoagulants (lupus anticoagulants) |
|
Definition
|
|
Term
Given the Disease(s) Detected, What is the Coagulation Test associated with it/them:
Elevated in hypo or dysfibrinogenemia. INCREASED in presence of FSP such as in DIC, if Heparin is present, or in Prothrombin Deficiencies |
|
Definition
|
|
Term
Given the Disease(s) Detected, What is the Coagulation Test associated with it/them:
Used to pinpoint the reason for an INCREASED TT. |
|
Definition
|
|
Term
| If the Reptilase Test is NORMAL and the Thrombin Time is INCREASED, what is present? |
|
Definition
|
|
Term
| If the Reptilase Test & the Thrombin Time are INCREASED, what 2 things may be present? |
|
Definition
| INCRASED FSP (DIC) or Hypofibrinogenemia |
|
|
Term
Given the Coagulation Test, what disease(s) may be detected?
PT |
|
Definition
| Coumadin therapy; liver disease; Vitamin K deficiency; DIC; EXTRINSIC factor deficiencies |
|
|
Term
Given the Coagulation Test, what disease(s) may be detected?
PT / APTT |
|
Definition
| INTRINSIC factor deficiencies, monitor heparin, DIC, Circulatin anticoagulants (lupus anticoagulants) |
|
|
Term
Given the Coagulation Test, what disease(s) may be detected?
TT |
|
Definition
| Elevated in hypo or dysfibrinogenemia. INCREASED in presence of FSP such as in DIC, if Heparin is present, or in Prothrombin Deficiencies |
|
|
Term
Given the Coagulation Test, what disease(s) may be detected?
Reptilase Test |
|
Definition
| Used to pinpoint the reason for an INCREASED TT. |
|
|
Term
| Which Test is MOSTLY used to Monitor Coumadin? |
|
Definition
|
|
Term
True or False:
INR is used to monitor Coumadin AND You should report PT in seconds for other uses |
|
Definition
|
|
Term
True or False:
Heparin will also slightly INCREASE the PT |
|
Definition
|
|
Term
True or False:
Coumadin will also slightly INCREASE the PTT |
|
Definition
|
|
Term
True or False:
Coumadin will NOT slightly INCREASE the PTT |
|
Definition
|
|
Term
True or False:
Heparin will NOT slightly INCREASE the PT |
|
Definition
|
|
Term
True or False:
While the TT is INCREASED with Heparin Therapy, it is TOO Sensitive to Heparin to routinely monitor it |
|
Definition
|
|
Term
| Why do we not use TT to routinely monitor Heparin Therapy even though it is INCREASED with Heparin Therapy? |
|
Definition
| It is TOO Sensitive to Heparin to routinely monitor it. |
|
|
