Term
| Intrinsic system is measured by |
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Definition
|
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Term
| APTT measures ALL coagulation factors EXCEPT |
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Definition
|
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Term
| Factors measured by APTT include factors |
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Definition
| I, II, V, VIII, IX, X, XI, XII |
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Term
| APTT - Reagents include an ___ ___ (__), a ____ _____, and an ___ _ ___ ( ___ ___) |
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Definition
activation substance (actin)
-Phospholipid substitute
-Activator of XII (calcium chloride) |
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Term
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Definition
|
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Term
T or F:
You use the same device to measure APTT as you use to measure PT |
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Definition
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Term
| APTT is used to detect ___ ___ and to monitor ___ ____ |
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Definition
inherited deficiencies
heparin therapy |
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Term
| APTT (with heparin therapy) should be ___-___ times the baseline |
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Definition
|
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Term
| APTT can also be used to detect ____ and ___ ___ |
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Definition
DIC
Circulating anticoagulants |
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Term
| Factor assays are used to detect ____ ___ ___ |
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Definition
| inherited factor deficiencies |
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Term
| What 2 types of Plasma will you use in factor assays? |
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Definition
Pooled normal plasma
Factor deficient plasma |
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Term
| If patient is deficient in a factor, what will mixing the patient's plasma with pooled normal plasma do? |
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Definition
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Term
| % of factor activity is determined by the amount of _______ detected when specific dilutions of patient plasma are added to the factor-deficient plasma |
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Definition
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Term
| If patient has the factor that is missing in the factor-deficient plasma, the APTT will be _____ |
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Definition
|
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Term
| If the patient does NOT have the factor that is missing in the factor-deficient plasma, the APTT will still be ______ |
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Definition
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Term
| Normal range for Factor Assay Results |
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Definition
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Term
Factor Assay Results:
No bleeding tendencies until <_____ |
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Definition
|
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Term
Factor Assay Results:
Hemophilia values are often <______ |
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Definition
|
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Term
| What may be used when the APTT is prolonged? |
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Definition
| Mixing studies using patient plasma and normal plasma in a 50:50 mix (1:1) |
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Term
| If you use 50:50 and the APTT correct to normal, what will be present? |
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Definition
|
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Term
| If you use 50:50 and the APTT does NOT correct to normal, what will be present? |
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Definition
|
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Term
| Lupus is an example of what when referring to APTT? |
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Definition
|
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Term
| 3 Tests for common pathway |
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Definition
Thrombin Time
Reptilase
Fibrinogen |
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Term
| Time to convert fibrinogen to an insoluble fibrin clot after the addition of excess thrombin |
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Definition
|
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Term
| The reagent thrombin cleaves ____ |
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Definition
|
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Term
| What does Thrombin Time NOT measure? |
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Definition
| Intrinsic or Extrinsic pathways |
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Term
| Thrombin time by-passes the ____ |
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Definition
|
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Term
| Normal values of Thrombin Time are |
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Definition
|
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Term
| Thrombin Time will be prolonged in (5) |
|
Definition
hypofibrinogenemia
dysfibrinogenemia
heparin therapy
circulating anticoagulants
DIC |
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Term
| Thrombin Time is ____ ____ to heparin |
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Definition
|
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Term
| Reptilase measures conversion of ____ to ____ without ____ |
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Definition
|
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Term
T or F:
Reptilase is NOT affected by HEPARIN |
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Definition
|
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Term
| Thrombin clotting time is inversely proportional to the ____ ___ _____ |
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Definition
| concentration of fibrinogen |
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Term
| Normal Range of Clauss Method (Fibrinogen) |
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Definition
|
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Term
| _____ _____ ______ is inversely related to the concentration of fibrinogen |
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Definition
|
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Term
| ____ ___ ___ measures fibrin products |
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Definition
|
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Term
| ___-___ ___ measures the cross-linked fibrin |
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Definition
|
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Term
Latex Agglutination for FDP or FSP:
Latex particles are coated with __ _ & ___ ___ |
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Definition
|
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Term
| Normal for Latex Agglutination is <_____ |
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Definition
|
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Term
| Latex agglutination will be ______ in DIC and heart attack/thrombosis detection |
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Definition
|
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Term
D-Dimer Test:
______ also acts on the fibrin clot that leads to the generation of cross-linked fibrin containing D-dimer |
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Definition
|
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Term
| As the clot is broken down, the cross-links of factor _____ are removed, revealing fibrin monomers |
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Definition
|
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Term
| The D-dimer test specifically detects ___ __ _____ |
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Definition
|
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Term
| Positive D-dimer test may be seen whenever ____ occurs |
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Definition
|
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Term
| Positive D-dimer test will not be seen when ____ occurs |
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Definition
|
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Term
| Advantage of the D-dimer test is that there is no interference from |
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Definition
|
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Term
| 3 Miscellaneous Coag Tests |
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Definition
Factor XIII assay
Inhibitors to coagulation
Screening for Lupus anticoagulants |
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Term
| ______ is observed in DIC, Deep vein thrombosis, pulmonary embolism |
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Definition
|
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Term
| In absence of XIII, clots are ____ __ ___ ___ in a ___ ___ ___ |
|
Definition
unstable and easily soluble
weak urea solution |
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Term
| Factor XIII Screening Test |
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Definition
|
|
Term
| XIII converts ___ bonds to ____ bonds |
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Definition
|
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Term
| 3 Inhibitors to Coagulation |
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Definition
|
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Term
| ____ ___ ___ are commonly used to measure functional levels of inhibitors to coagulation |
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Definition
| Chromogenic automated methods |
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Term
| ____ ____ are used to screen for Lupus Anticoagulants |
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Definition
|
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Term
| 3 Tests used to Confirm Lupus Anticoagulants |
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Definition
Platelet Neutralization Test
Anti-phospholipid ABY
Dilute Russell's Viper venom |
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|
Term
| ____ _____ are ABYs against phospholipids, observed in SLE, autoimmune disorders, malignancies, and certain drugs |
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Definition
|
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Term
| Factors used in Adsorbed Plasma |
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Definition
|
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Term
| Factors used in Aged Serum |
|
Definition
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