Shared Flashcard Set

Details

Hematology and Oncology
Pharmacology
82
Pharmacology
Graduate
01/17/2014

Additional Pharmacology Flashcards

 


 

Cards

Term
activation of ATIII
Definition
heparin
Term
anticoagulant in pregnancy
Definition
heparin
Term
heparin OD
Definition
protamine sulfate
Term
LMW heparins MOA
Definition
act more on Xa
Term
advantage of LMW heparins
Definition
no lab monitoring
Term
HIT mechanism
Definition
heparin binds factor 4, causing ab production that binds to and activates platelets, leading to their clearance and resulting in a thrombocytopenic, hyper coagulable state
Term
used in patients with HIT
Definition
lepirudin, bivalirudin
Term
direclty inhibit thrombin
Definition
lepirudin, bivalirudin
Term
inhibits vitamin K
Definition
warfarin
Term
warfarin monitorin
Definition
PT/INR
Term
heparin monitoring
Definition
PTT
Term
warfarin toxocity
Definition
teratogenic, bleeding, skin/tissue necrosis
Term
Hep vs warfarin: small lipid soluble
Definition
warfarin
Term
Hep vs warfarin: large, anionic
Definition
heparin
Term
Hep vs warfarin: parenteral
Definition
heparin
Term
Hep vs warfarin: oral
Definition
warfarin
Term
Hep vs warfarin: rapid
Definition
heparin
Term
Hep vs warfarin: slow
Definition
warfarin
Term
Hep vs warfarin: acute onset
Definition
hep
Term
Hep vs warfarin: chronic onset
Definition
warfarin
Term
Hep vs warfarin: crosses placenta
Definition
warfarin
Term
ex of thrombolytics
Definition
streptokinase, urokinase, tPA and anistreplase
Term
convert plasminogen to plasmin
Definition
thrombolytics
Term
thrombolytic toxicity tx
Definition
aminocaproic acid
Term
thrombolytic CI
Definition
active bleeding, intracranial bleed, recent surgery, bleeding diatheses, or severe hypertension
Term
inhibit M phase
Definition
vinca alkaloids and taxols
Term
INhibits G2 phase
Definition
bleomycin, etopside
Term
Inhibits S phase
Definition
etopside, antimetabolites
Term
inhibit nucleotide synthesis
Definition
MTX, 6-MP
Term
inhibit DNA synthesis
Definition
alkylatig agents, cisplatin dactomycin, doxorubicin, etopside
Term
inhibit cellular division
Definition
vinca alkaloids, paclitaxel
Term
folic acid analog
Definition
methotrexate
Term
leukemias, lymphomas, choriocarcinoma and sarcomas
Definition
MTX
Term
abortion, ectopic pregnancy, RA, psoriasis
Definition
MTX
Term
reversible with leucovorin
Definition
MTX
Term
fatty liver change, mucositis, teratogenic
Definition
MTX
Term
pyrimidien analog
Definition
5-FU, cytarabine
Term
inhibits thymidylate synthase
Definition
5-FU
Term
topical for basal cell
Definition
5-FU
Term
rescue with thymidine
Definition
5-FU
Term
purine analog
Definition
6-MP, 6-TG
Term
activated by HGPRTase
Definition
6-MP
Term
metabolized by xanthine oxidase
Definition
6-MP
Term
bone marrow depression, liver
Definition
6-MP, 6-TG
Term
SE megaloblastic anemia
Definition
cytarabine
Term
AMl, ALL, NH lymphoma
Definition
cytarabine
Term
ALL
Definition
6-TG
Term
antitumor abx that intercalates DNA
Definition
dactomycin
Term
wilm's tumor, ewing, rhabdomyosarcima
Definition
dactinomycin
Term
generates free radical -> noncovalently intercalate in DNA
Definition
doxorubicin
Term
cardiotoxicity
Definition
doxorubicin, trastuzumab
Term
how prevent cardiotoxicity with doxorubicin?
Definition
dexrazoxane
Term
free radical formation -> breacks in DNA
Definition
bleomycin
Term
testicalar cancer
Definition
bleomycin
Term
SE pulmonary fibrosis
Definition
bleomycin, busulfan
Term
alopecia
Definition
doxorubicin, etopside
Term
inhibits topoisomerase II
Definition
etopside
Term
links DNA at guanine N-7
Definition
cyclophosphamide
Term
hemorrhagic cystitis
Definition
cyclophosphamide
Term
cross BBB
Definition
nitrosureas
Term
brain tumors
Definition
nitrosureas
Term
SE CNS toxicity
Definition
nitrosureas
Term
CML
Definition
busulfan, imanitib, hydroxyurea
Term
hyperpigmentation
Definition
busulfan
Term
inhibits microtubule assembly
Definition
vincristine/vinblastine
Term
wilm's choriocarcinoma, ALL
Definition
vincristine/vinblastine
Term
peripheral neuropathy
Definition
vincristine
Term
MT inhibitor with myelosuppression
Definition
vinblastine, paclitaxel
Term
inhibits tubulin disassembly
Definition
paclitaxel
Term
cross links DNA
Definition
cisplatin, carboplatin
Term
nephrotoxic and ototoxic
Definition
cisplatin, carboplatin
Term
how prevent nephrotoxicity with cisplatin?
Definition
amifostine and chloride diuresis
Term
inhibits ribonucleotide reductase
Definition
hydroxyurea
Term
melanoma, sickle cell
Definition
hydroxyurea
Term
prednisone SE
Definition
cushing like, immunosuppression, cataracts, acne, osteoporosis, HTN, peptic ulcers, hyperglycemia and psychosis
Term
blocks biding of estrogen to estrogen receptors
Definition
tamoxifen, raloxifene
Term
may increase risk of endometrial cancer
Definition
tamoxifene; NOT raloxifene
Term
monoclonal ab to Her-2 neu
Definition
trastuzumab
Term
bcr-abl inhibitor
Definition
imanitib
Term
SE fluid retention
Definition
imatinib
Term
monoclonal ab to CD20
Definition
rituximab
Term
RA, NH lymphoma
Definition
rituximab
Supporting users have an ad free experience!