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Hematological System
lecture 5 part 2
66
Pathology
Graduate
07/09/2014

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Term
Which system involves the blood and blood-forming tissue?
Definition
hematological system
Term
The hematological system is vital for what?
Definition
cellular metabolism, fighting injury and infection, maintaining homeostasis within the body
Term
accumulation of excess fluid within the interstitial tissues or in the body cavities
Definition
edema
Term
accumulation of excess blood in blood vessels of an organ or tissue
Definition
congestion
Term
thrombus vs embolus: which one is moving?
Definition
embolus
Term
accumulation of lymphatic fluid within the lymphatic system
Definition
lymphedema
Term
characterized by a reduction in oxygen-carrying capacity due to an abnormality in the number or quality of the RBCs
Definition
anemia
Term
Anemia Cause 1
Definition
excessive blood loss
Term
Anemia Cause 2
Definition
increased destruction of RBCs
Term
Anemia Cause 3
Definition
decreased production of RBCs
Term
Most common anemias
Definition
nutritional, iron, sickle cell
Term
Mild cases of anemia may be
Definition
asymptomatic
Term
At what level must hemoglobin and hematocrit levels fall before symptoms typically arise
Definition
below 50%
Term
WWeakness, dyspnea upon exertion, pallor, fingernail changes, tachycardia, angina, leg ulcers
Definition
potential symptoms of Anemia
Term
Exercise programs and the Anemic
Definition
should be approved by MD
Term
What should be expected when the Patient with anemia is exercising
Definition
shortness of breath and fatigue
Term
What should therapist be cautious with when working with an Anemic patient?
Definition
exercise intensity and patient's O2 supply
Term
a chronic anemia where the RBCs rupture into sickle-cell shaped cells
Definition
sickle cell anemia
Term
WHy is sickle cell anemia dangerous
Definition
sickle cells lose their hemoglobin becoming ineffective transporters of O2
Term
Rapid progressive malignant disease of the bone marrow and blood
Definition
acute leukemia
Term
Acute leukemia results in what
Definition
accumulation of non functional, immature cells which block the development of normal cells
Term
What can lead to acute leukemia
Definition
DNA alteration
Term
What does DNA alteration lead to in Acute Leukemia?
Definition
production of blood cells that are immature and do not functional properly
Term
WHat sort of cells accumulate in the bone marrow and blood stream with acute leukemia?
Definition
neoplastic cells
Term
What do the neoplastic cells do during acute leukemia?
Definition
invade surrounding tissue, leading to failure of the bone marrow to produce normal blood cells
Term
What are the initial symptoms of acute leukemia like?
Definition
flu like
Term
The symptoms of acute leukemia progress to what?
Definition
bleeding within the skin, in the gums, abnormal bleeding during menstruation
Term
WHat are other common symptoms of acute leukemia?
Definition
bone pain, joint pain, neurologic symptoms
Term
Malignancy that originates in the lymphoid system that primarily affects the lymph nodes
Definition
hodgkins' disease
Term
Hodgkin's disease is characterized by what
Definition
oversized reed-sternberg cells
Term
The Reed-sterberg cells are part of what?
Definition
macrophage system
Term
The Reed-Sternberg cells have what sort of appearance
Definition
twin nuclei, owl-eye
Term
Hallmark symptoms of Hodgkins Disease
Definition
fever, night sweats, anorexia, weight loss
Term
Hodgkins' disease affects what systems?
Definition
lymphatic, pulmonary, CNS
Term
Hodgkins Disease Systemic S/S: Face and Neck
Definition
swelling
Term
Hodgkins Disease Systemic S/S: pulmonary
Definition
cough, dyspnea, chest pain
Term
Hodgkins Disease Systemic S/S: CNS
Definition
nerve pain, paraplegia
Term
Why does swelling of the face and neck occur during Hodgkins Disease
Definition
lymph node swelling and obstruction of lymphatic flow
Term
Why do pulmonary symptoms occur during Hodgkin's disesae
Definition
involvement of lung tissue, pleura, and pulmonary lymph nodes
Term
What is the CNS affected during Hodgkin's disease
Definition
nerve compression
Term
Decrease in the concentration of thrombocytes
Definition
thrombocytopenia
Term
Why does thrombocytopenia occur?
Definition
leukemia, metastatic cancer, aggressive chemotherapy, aplastic anemia
Term
How is thrombocytopenia caused: 1
Definition
underproduction of platelets from the bone marrow
Term
How is thrombocytopenia caused: 2
Definition
increased platelet destruction outside the marrow
Term
How is thrombocytopenia caused: 3
Definition
pooling of blood within the spleen
Term
epistaxis
Definition
nosebleed
Term
purpura
Definition
discoloration of the skin caused by subcutaneous bleeding, easy bruising
Term
melena
Definition
black, tarry feces associated with a GI bleed
Term
Hematuria
Definition
blood in the urine
Term
gingival bleeding
Definition
gums bleeding
Term
Signs of thrombocytopenia
Definition
epistaxis, purpura, melena, hematuria, excessive menstrual bleeding, gingival bleeding
Term
Why should the therapist be very careful about duration, intensity, frequency, of exercise with thrombocytopenia
Definition
strenous exercise could lead to hemorrhage, particularly of the eyes or brain
Term
Instruments, devices, or garments that apply external pressure to the body and using them with a patient with thrombocytopenia
Definition
avoid usage, as this may precipitate hemorhage
Term
Most common inherited bleeding disorder
Definition
hemophilia
Term
How is hemophilia caused?
Definition
abnormality of plasma-clotting proteins necessary for coagulation
Term
Danger of hemophilia
Definition
prolonged bleeding
Term
Three levels of hemophilia
Definition
mild, moderate, severe
Term
Most common forms of Hemophilia: 1
Definition
Hemophila A
Term
Most common forms of Hemophilia: 2
Definition
Hemophilia B
Term
Hemophila A is a decrease of what?
Definition
F8
Term
Hemophilia B is a decrease of what
Definition
F9
Term
What are early signs of hemophilia
Definition
slow persistent bleeding, delayed hemorrahge, easy bruising
Term
Why is exercise beneficial for hemophiliacs
Definition
decreases the frequency of bleeds
Term
Exercise temporarily increases the circulation of clotting factors in those with which factor deficiency
Definition
8, Type A hemophilia
Term
Studies show bleeding episodes in children who are physically active are ______ than their sedentary peers
Definition
less
Term
Hemophila PTI
Definition
injury prevention, conditioning and wellness
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