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Hematologic Diseases1
Oral Pathology
60
Dentistry
Professional
09/16/2013

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Term
Clinical features of hematologic disease
Definition
Infection (bacterial, fungal, viral), gingivitis, ulceration, recurrent aphthae, hemorrhage, pain & nerve damage, angular cheilitis, cervical lymphadenopathy & tonsil enlargment, Glossitis, petechiae, blood blister
Term
Suitable screening hematologic failure:
Definition

1. BT (bleeding time)

2. CT (clotting time)

3. Platelet count

4. PT-protime

5. PTT - partial thromboplastin time or activated PTT

Term
Anemia
Definition

Decrease in # of circulating erythrocytes

Low hemoglobin, low RBC count, low HCT

Term
Systemic manifestations of anemia
Definition

koilonychia, brittal nails

Weakness/tired, shortness of breath, pallor, tachycardia

paresthesias of extremities

Gait disturbances

motor impairment

Loss of position or vibration sense

Disturbances of taste and smell

Disturbances of memory & affect, forgetfullness, mental slow, depression, irritability or paranoid psychosis

Term
Oral manifestations of anemia
Definition
Stomatitis, angular cheilitis (58%), atrophic glossitis, glossodynia, recurrent oral ulcerations, oral candidiasis, mucosal pallor, taste disturbances.
Term
Etiology of Vitamin B12 deficiency (pernicious anemia)
Definition

Megaloblastic anemia due to impaired DNA synthesis

Autoimmune, gastrectomy, H. pylori infection

Term
Clinical manifestations of pernicious anemia (Vit B12 deficiency)
Definition
Generalized weakness; glossodynia, atrophic glossitis (Hunter's glossitis, Moeller's glossitis); numbness or tingling
Term
Oral manifestations of pernicious anemia
Definition

Normal tongue, glossodynia, atrophic glossitis, recurrent aphthous ulcers, mucosal pallor

Fissured and mild geographic tongue

Term
Lab findings/diagnosis of pernicious anemia
Definition

macrocytic erythrocytes, multisegmented neutrophils; decreased Vit B12; decreased MMA, Schiling test; atrophic glossitis;antibodies to intrinsic factor are present in serum and saliva

Oral biopsy: mucosal atrophy, increased N/C ratio, chronic inflammation

Term
Treatment of pernicious anemia
Definition

Colabamin injection, high-dose oral or nasal spray

Life-long

Prevents further degernation of nerves

Term
Prognosis of pernicious anemia
Definition

Good w/ treatment

Gastric carcinoma 1-2%

Term
Folate deficiency etiology
Definition

- Megaloblastic anemia due to impaired DNA synthesis

- Associated with: alcoholism, hemodialysis, phenytoin, oral contraceptives, methotrexate

- Assoc. w/ cleft lip, cleft palate, neural tube defects, increased risk of colon cancer & heart disease & stroke

Term
Oral manifestations of folate deficiency
Definition

- Sore, atrophic glossitis

- Angular cheilitis

- Candidiasis

- Recurrent aphthous ulcers

Term
Treatment & prognosis of folate deficiency
Definition

Replacement therapy

Excellent w/ treatment

Term
Iron deficiency causes
Definition
reduced production in # of cells
Term
iron deficiency etiology
Definition
decreased intake of iron, excessive blood loss women>men, increased demand, decreased absorption of iron (gastrectomy, celiac sprue)
Term
Clinical features of iron deficiency
Definition
Fatigue, palpitations, lightheadedness, lack of energy
Term
Oral manifestations of iron deficiency
Definition
Angular cheilitis, atrophic glossitis, mucosal atrophy, candidiasis, increased risk of aphthous ulcers
Term
Lab diagnosis of iron deficiency
Definition

- CBC and differential reveals microcytic hypochromic anemia

- Total ferritin decreased, total iron binding capacity

Term
Treatment and prognosis of iron deficiency anemia
Definition

- Replacement therapy

- PX: iron deficiency w/ increased risk of cancer of upper aerodigestive tract; Plummer-Vinson Syndrome (patternson-Kelly syndrome, sideropenic dysphagia) - women in 4th-5th decades, mucosal atrophy, impaired cell-mediated immune response

Term
Plummer-Vinson Syndrome
Definition
Esophageal webs, difficulty swallowing (dysphagia), yellowish/dry skin, atrophic glossitis, increased risk of dev oral cancer and cancer of URT
Term
Defintion of aplastic anemia "pancytopenia"
Definition
Reduced # of cells due to failure in production
Term
Etiology of aplastic anemia "pancytopenia"
Definition
Immune mediated cytotoxic T lymphocytes, Idiopathic, radiation, chemo, drugs (chloramphenicol, gold, NSAIDs); toxins-benzene, viruses (papovavirus; HIV; non-A, non-B, non-C, non-G hepatitis); hereditary disease-Fanconi's anemia (autosomal recessive), dyskeratosis congenita
Term
Clinical features of aplastic anemia
Definition

Lightheadedness, tachycardia, weakness

Thrombocytopenia-bruising & bleeding tendency

Bacterial and fungal infections

Term
Oral manifestations of Aplastic anemia
Definition
Oral petechiae (pinpoint), purpura, ecchymosis (large areas), hemorrhage, pale mucosa, minimal erythema around ulcers, gingival hyperplasia
Term
Aplastic anemia: diagnosis and histology
Definition

Pancytopenia: decrease in all formed elements

DX: complete blood cell count & differential, bone marrow aspiration or biopsy

- Complete blood cell count exhibits at least 2 of the following: <500 granulocytes, <20,000 platelets, <10,000 reticulocytes

- Bone marrow aspiration and biopsy

- Histology: marrow hypoplasia (increased fat and decreased cellular elements)

Term
Treatment for aplastic anemia
Definition

Withdrawal of offending agent if known

Supportive therpay including transfusions

Androgenic steroids helpful in mild disease

If immuned mediated: corticosteroids, anti-lymphocyte globulin and cyclosporine

Bone marrow transplant

**very serious disease

Term
Asplastic anemia prognosis
Definition

Unpredictable-guarded

Anti-lymphocyte globulin and cyclosporine, help 90% 3 yr SR

Bone marrow transplant, risk of Graft vs. Host disease, may recur, increased risk of hematologic malignancy (acute leukemia)

Term
Hemolytic anemia definition
Definition
Anemia due to increased destruction or loss of cells; reduced RBC survival (destruction in spleen and liver)
Term
Intrinsic defects for hemolytic anemia
Definition

- Hereditary spherocytosis: most common RBC membrane defect

Glucose-6-phosphate dehydrogenase enzyme defect

Pyruvate kinase deficiency = enzyme deficiency --> chronic hemolytic anemia

Thalassemia: alpha or beta chains; inherited autosomal recessive

sickle cell anemia

Term
Extrinsic defects of hemolytic anemia
Definition

Erythroblastosis fetalis


Transfusion rxns

Mechanical trauma-prosthetic heart valve

Disseminated intravascular coagulation (DIC)

Hyperplenism

Term
Characteristics of Thalassemia
Definition

Mediterranean, African, Indian, Southeast Asian

Excess alpha or beta globulin chains results in abnormal RBCs filtered out by spleen --> microcytic, hypochromic anemia

Common

Wide range of clinical severity (over 200 known mutations)

Term
Alpha genes of thalassemia
Definition

1 abnorm gene = no clinical disease

2 abnorm genes = alpha-thalassemia trait

3 abnorm genes = HbH disease

4 abnorm genes = hydrops fetalis

Term
Beta genes of thalassemia
Definition

Minor: heterozygous

Major: homozygous, Cooley's anemia or Mediterranean fever

Term
Diagnosis/Lab findings w/ Alpha Thalassemia
Definition
Hypochromic, microcytic anemia (same with iron deficiency)
Term
Diagnosis/Lab findings of beta thalassemia
Definition
Hypochromia, dark cell is orthochromic normoblast, microcytic
Term
Oral manifestations of thalassemia
Definition
Prominent premaxilla, malocclusion, mucosal pallor, development of dentition delayed by one year
Term
Radiographic features of thalassemia
Definition
Osteoporosis, loss of trabeculae, coarse trabeculae, "Hair on end"
Term
Treatment for thalassemia
Definition

Thalassemia major-blood transfusion

Bone marrow transplant

Surgery to remodel facial defects

Term
prognosis of thalassemia
Definition

w/out treatment-death in 1st year of life w/ major

Hemochromatosis-toxic to heart, liver, endocrine

Prevention - screen to detect carries; prenatal diagnosis

Term
Etiology of sickle cell anemia
Definition

point mutation HbS

Thymine substitution adenine in DNA, codon altered to valine rather than glutamic acid in the beta-globin chain of hemoglobin

RBCs - marked tendency for deformation

Term
Inheritance pattern of sickle cell anemia
Definition

Autosomal co-dominant, one gene 40-50% Hgb S

Heretozygous-trait, homozygous-disease

Term
Clinical features of sickle cell anemia
Definition
Low oxgen tension, infection, hypothermia, dehydration
Term
Clinical features of sickle cell anemia
Definition
Low oxygen tension, infection, hypothermia, dehydration
Term
What is sickle cell crisis?
Definition

Sequestration of RBCs, infarcts in femoral head, osteomyelitis, spleen --> atrophy, skin of ankle ulcers, CHF, CVA

Aplastic splenic atrophy predisposes to infection

Term
Treatment for sickle cell anemia
Definition
Penicillin, hydoxyurea to increase fetal hemoglobin F, bone marrow transplant
Term
Prognosis of sickle cell anemia
Definition
Variable, genetic screening/prenatal diagnosis
Term
Definition of erythoblastosis fetalis
Definition
Hemolytic anemia of newborns
Term
etiology of erythoblastosis fetalis
Definition
blood component incompatibility b/t mother and fetus, usually Rh factor
Term
Clinical features of erythoblastosis fetalis
Definition

Intrinsic stain (blood pigments deposited in teeth, green-blue-brown)

Enamel hypoplasia

Term
Differential diagnosis of erythoblastosis fetalis
Definition

tetracycline yellow-brown

porphyria red-brown

Term
Treatment for erythoblastosis fetalis
Definition

Dental: none necessary, usually affects only primary dentition

Systemic: whole body transfusion

Term
Prognosis of erythoblastosis fetalis
Definition
Use of anti-antigen gamma globulin after delivery prevents formations of antibodies that would endanger future pregnancies
Term
Definition of polycythemia rubra vera
Definition

myeloproliferative disease: increased #s of RBCs and platelets, plus or minus increase in granulocytes

>40 years, median 60 M=F

Term
Etiology of polycythemia rubra vera
Definition
95% tyrosine kinase gene mutation (Janus kinase 2)
Term
Clinical features of polycythemia rubra vera
Definition

Headache, weakness, dizziness, drowsiness, visual disturbances, sweating, weight loss, dyspnea, epigastric pain, generalized pruritis (40%), erythromelalgia

Vascular thrombosis --> CVA, MI

Hemorrhage, epistaxis, ecchymoses, ginival

Term
Treatment for polycythemia rubra vera
Definition
Phlebotomy, aspirin, antihitamines, anagrelide hydrochloride (selectively inhibits megakaryocyte maturation and platelet production), myelosuppressive agents, hydroxyurea
Term
Prognosis for polycythemia rubra vera
Definition

Fair, average survival 10-12 yrs after diagnosis

Myelofibrosis 15%

Leukemia 2-10% usually acute

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