Term
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Definition
| Arterial vasodilator used in CHF |
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Term
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Definition
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Term
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Definition
Digitalis glycoside
Inh Na/K ATPase => inc IC Na, and therefore Ca => inc contractility
Inh Na/K ATpase => inc baroreceptor sensitivity => dec symp activity => venous & art. pressure
Reduced Hrt size
Inc diuresis |
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Term
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Definition
Based on lean body mass
Oral and IV
Renal excretion |
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Term
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Definition
NARROW THERAPEUTIC INDEX
cardiac arrythmia
anorexia, N/V, diarrhea
vision problems, delirium, HA, fatigue
*Rx toxicity w: K infusion if hypoK, Digibind (Ab), and antiarrythmic |
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Term
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Definition
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Term
| *Sympathomimetic amine mechanism of effect on contractility |
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Definition
stimlate adenylyl cyclase, inc cAMP
includes Dobutamine |
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Term
| *Phophodiesterase inh mechanism of effect on contractility |
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Definition
| Inh phosphodiesterase type 3, inc cAMP |
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Term
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Definition
Relaxes veins and arterioles via NO formation
Used in CHF pts |
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Term
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Definition
Alpha1 adrenergic blocker
Dilates veins and aa
Used in systemic or pulm HTN |
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Term
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Definition
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Term
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Definition
ACE inh (prodrug- must be DEESTERIFIED)
half life substantially linger that captopril
Fewer GI effects than captopril
Oral |
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Term
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Definition
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Term
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Definition
Inh conversion of angiotensin I to ang II
Inc bradykinin (a vasodilator)
Relaxes aa and vv
Reduces aldosterone
Dec symp activity |
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Term
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Definition
hypoTN
pesistent cough
angioedema can be life threatening
DON'T USE IN 2ND and 3RD TRIMESTER
hyperkalemia |
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Term
| Angiotensin II Rec blockers |
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Definition
Losartan
Valsartan
Act by binding Ang II rec
Do not inh bradykinin breakdown |
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Term
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Definition
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Term
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Definition
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Term
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Definition
angioedema
dizziness
inc liver enzymes |
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Term
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Definition
angioedema
dizziness
inc liver enzymes |
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Term
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Definition
blocks aldosterone binding
dec plasma vol and myocardial remodeling |
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Term
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Definition
| nonselective beta- and alpha- adrenergic rec antagonist |
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