Shared Flashcard Set

Details

HD-Immunology-TLRs
TLRs
15
Medical
Graduate
12/09/2010

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Cards

Term
TLR1:TLR:2
Definition
PM. Bacterial Triacylated lipopeptides
Term
TLR2
Definition
PM. Bacterial peptidoglycan, lipoprotein, lipoteichoic acid, porins and viral hemagglutinin
Term
TLR4
Definition
PM. G-LPS, Fungal mannans, parasitic phospholipids, viral envelope proteins and heat shock proteins
Term
TLR5
Definition
PM. Bacterial Flagellin
Term
TLR2:TLR6
Definition
PM. Bacterial diacylated lipopeptides and lipoteichoic acid
Term
TLR3
Definition
Endo. Viral dsRNA
Term
TLR7 and TR8
Definition
Endo. Viral ssRNA
Term
TLR9
Definition
Endo. Unmethylated CpG dinucleotides
Term
My cytoplasmic domain does not bind to MyD88
Definition
TLR3
Term
NF-kB
Definition
Transcription of IL-6, TNF, IL-1, IL-12, IL-8, E Selectin and MCP-1
Term
AP-1
Definition
Transcription of IL-6, TNF, IL-1, IL-12, IL-8, E Selectin and MCP-1
Term
IRF3
Definition
Transcription of IFN a/b
Term
CD14
Definition
Binds LPS carried by LBP. Binds MD2 to activate TLR4
Term
C-Type Lectins
Definition
Calcium-dependent. Bind mannose (for one). Expressed on macrophages, dendritic cells and CTLs
Term
FPR and FPRL-1
Definition
Expressed on Neutrophils and macrophages respectively. Bind N-Formyl Met-Leu-Phe. GPCRs
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