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Definition
| Causes the release of excess amts of neurotransmitters by interfering with reuptake of dopamine and norepinephrine. It also displaces NT from presynaptic nerve terminals causes an increase release. |
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Definition
Analgesics - depresses the CNS
Blocks the mu site receptors on nerve cells. |
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Definition
| NMDA receptor antagonist, which blocks the activity of the NMDA receptor and |
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| Binds and activates THC receptors in the cerebellum and hipocampus. Inhibits Adenylate cyclase |
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Definition
| Gamma-hydroxybutyrate / MDMA acts as a releasing agent of serotonin, norepinephrine, and dopamine |
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Benzodiazepines
- pam flurazepam (rohypnol), diazepam(valium), aprazolam (xanax), chloridazapoxide (lithium) , clonazepam(ativan), |
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Definition
allosteric modification of a specific kind of neurotransmitter receptor, the GABAA receptor, which increases the conductance of this inhibitory channel; this results in the various therapeutic effects as well as adverse effects.
SXS: decreases BP, urinary retention, visual disturbances, memory impairment, dizziness, confusion,
Adverse effects: Resp failure, cardiovascular collapse
RX: Flumenazil |
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Definition
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Definition
| inhibition or displacces the NT serotonin |
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Term
| Inhailants : chloroform, methylich, nitrates |
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Definition
| Volitile organic compounds (aerosols with flurocarbons, alcohol, keytones) can potentially produce nerological, CV, and liver toxicity |
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Definition
Blocks re-uptake of neurotransmitters Nerepinephrine, serotonin,dopamine,
Major metabolite = benzoylecogine, ergonine
With Alcohol forms = cocaethylene
Schedule II
SXS; increase HR, BP, muscle tension , increased temp.
Morbidity: MI, CVI, coronary vasospasm, cardiach arrythmis, seizure, resp depression. |
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Definition
Cd found in fire detection systems, cables, ceramics, glass, batterie manufacturing.
acute sxs: irritation, dizzy, chills, fever , chest pain.
SXS: Proteinuria, stored in bones and causes bone pain. HTN,COPD, Lung cancer
Itai Itai disease |
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Definition
Occupational Asthma
Lung Cancer (squamous cell carcinoma)
Pulm Edema
Related jobs : Nickel Ore extraction, smelting, smelting, fossil fules |
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Definition
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| Chloracne is caused by which chemicals |
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Definition
Halogenated hydrocarbons
Dioxin
Polychlorinated dibenzos
Tetrachorodibenzo |
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Definition
Occupational Asthma
Lung Cancer / nasal cavity
Nasal irritant
Fibrosis
Alergic dermatitis
Related Jobs; Paint proments , reduction of chromite ore, cement work |
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Definition
Depolarizes presynaptic nerve terminals causing repatitive firing and seizures
(DDt, lindane)
lipid soulable, low degration |
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Definition
Inhailant
Liver cancer
Acroosteolysis= xray with finger tips of bones gone |
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Definition
Inhailant
Leukemia with dammage to bone marrow |
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Definition
Mentral irregularities
decreased fertility |
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Definition
Inhailant
Farmers Lung = fibrogenic process or pnemoconisosis
Also know as Broncholitis Obleterans which is a restrictive lung disease |
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Definition
fibrogenic process or pneumoconiosis.
Seen in pt exposed to NO, silica, asbestos, fiberglass. |
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Definition
Inhailant
Narcotic effects
hepatotoxin |
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Definition
Inhailant
Neurotoxin
SXS; Angina Pectoris & Atherosclerosis |
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Definition
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Definition
Inhailant
Sensitizers
interferes with cytocrome oxidase |
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Definition
Inhailant
Sensitizers. Byssinosis from cotton is due to sensitization reaction
interferes with cytocrome oxidase |
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Definition
Green or Yellow with odor
HCl in airways causes a topical necrosis
In peripheral airways O2 free rads which react with sulfhydryl groups and dammage aveolar-cap membrane.
SXS; Irritation
Pulm Edema
Death due to Laryngospasm |
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Definition
Causes ischemic anoxia (binds hem) & hypoxia. Also Cytotoxic (interfers with e- transfere). Resulting in vasospasms of the cerebral blood vessels and dammage to the blood barrier. Neronal loss occurs in thte basal ganglia & perkinji cells. (results in an autoimmune state)
SXS; confusion, ataxia, rigidity, encephalopathy, parkinson like state |
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Definition
In-utero exposure: Necrosis of cells of the cerebral cortex resulting in a syndrom akin to cerebral palsy after in-utero exposure.
Neropathy by focal necrosis of neurons
Chronic Exposure; tremmor, parkinson-like, dysarthria, coma, protenuria, axatia, constricution of the visual feilds.
Acute exposure to Inorganic mercury: gastroenteritis, and acute tubular necrosis.
SXS;DMSA |
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Definition
When inhailed casues neuronopathy. safest unless inhailed
Chronic sxs: stamatiti, gingivitis, tremor,
acute sxs: pnuemonitits, pulm fibrosis, renal dysfunction
RX: BAl, DMSA |
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Definition
Neronal loss, axon degeneration
decreased circulating leukocytes due to bone marrow dammage
SXS; optic neuritis
peripheral neuropathy |
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Definition
Neuronal Degeneration affects cortical grey matter and white matter (globus pallidus)
Inhibits cytochrom oxidase and produces cellular or cytotoxic anoxia. (interferes with e- transfer)
- causes mitocondrial dysfunction
SXS; coma , confusion, dystonia, rapid death
RX: Sodium Nitirite |
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Definition
Causes spongy axonal degeneration and vacudization of cerebellum and peripheral nerves (pyridoxine protects)
occupational Asthma
peripheral neuropathy sensory
Ataxia in high doses |
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Definition
neurotransmission- Associated Abnormalities
-Binds to Nicotinc cholinergic receptos
SXS; increased HR and BP |
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Definition
chemical in the industrial production of isocynates, herbicides, pesticides, analin dyes, or combustion chlorinated hydrocarbons
Sxs: cough due to pulm edema or death due to laryngospasm. |
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Definition
Used in the production of viscose rayon, cellophane, pesticides.
Interacts with free amine and sulfhydryl groups
SXS; psychosisis, parkinsons tremmor , polyneuritis,Angina Pectoris, Altherosclerosis
Causes: Axonopathy / neuronal degeneration in CNS, myelin Swelling and fragmentation in PNS |
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Definition
| SXS; acrocyanosis, and reynaud's , hyperpigmentation and gangreen. Black foot disease , Hemolytic anemia , jaundice , Lung cancer. |
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Definition
Freon
Cardiach arrythmia and hypoxia. |
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Definition
N-hexane and n butyl Keytone
used in glues, shoes, fabrics
- swelling large axons
- Increase nerofillaments
- causes peripheral neuropathy |
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Definition
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Degeneration of the striatum, globus pallidus
- visual and auditory HA
- parkinsons like syndrome |
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Definition
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Definition
| Pulm Asthma , looks like sarcoidosis on xray |
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| Trichloroethylen & ethanol |
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Definition
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Definition
Spontaneous abortion, still birth
Birth defects |
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Metal Fume fever
no change on xray |
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axonal degredation
Anicholinesterases
Sxs; midriais, salivation, lacrimation, diarrhea, gastric, emesis
parkinsonism , peripheral neuropathies, cortical blindness. |
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Definition
| high concentrations of NO2 |
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Definition
| Headache, SOB, CP, fever in a patient who has been exposed to metal and zinc |
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Definition
| Exposure with fruit and vegitable workers |
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Definition
present in cement
- can cause caustic skin burns |
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Definition
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combustion products and plastics
- Breakdown products Mandelic and phenyglyoxlic acid |
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A gasoline and solvent
SXS: CNS dysfunction
Arrhythmia, Renal Tubual acidosis
Breakdown into hipparic acid and cresol |
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| Urine confirmation of heroine use |
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Definition
| Morphine in blood and urine. codine or 6-MAM in the urine |
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Definition
Crude Oil, Coal Compustion
Breakdowns into methylhippuric acid |
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Definition
| Respiratory irritant and green coloration |
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