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Gram Negative Bacteria
Gram Negatives
28
Nursing
Graduate
10/05/2014

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Term
Gram Negative Cocci (2)
Definition
- Neisseria gonorrhoeae
- Neisseria meningitidis
Term
Neisseria
Definition
- pairs of cocci with adjacent sides flattened
- kidney shaped
- capsules and piliated cells for motility
Term
N. gonorrhoeae
Definition
- agent for gonorrhea
- causes PID
- Dissemination results in joint infection (gonococcal arthritis), meningitis, and septicemia
- gram negative intracellular cocci in pairs, kidney shaped,
- ex. guy with knee pain and no hx of break in skin
Term
What causes PID???
Definition
N. gonorrhoeae
- gram negative cocci
Term
N. meningitidis
Definition
- meningococcal meningitis (HIGHLY CONTAGIOUS)
- primarily due to antiphagocytic properties of the capsule
- bacteremic phase = macular rash and petechial hemorrhages
- immunity by polysaccharide A, C
Term
Bacterial Meningitis - clinical features
Definition
- extremely ill patients
- nuchal rigidity
- fever
- AMS
- headache, photophobia, seizures, focal neuro deficits, petechiae or purpura
Term
Bacterial Meningitis - Diagnostic studies
Definition
- CSF
- gram stain
- protein concentration >500 mg/dl
- Glucose <45 mg/dl
- WBC > 1000/uL
- culture
*TX IMMEDIATELY
Term
Gram Negative Rods (6)
Definition
- facultative enteric rods
- Bacteroides
- Pseudomonads
- haemophilus, bordetella, zoonoses
Term
Enterobacteriaceae
Definition
- Escherichieae (E. Coli), Klebsiellae, Proteae, Yersinieae, Erwinieae.
- Note ESBLs (Extended Spectrum beta lactamase) and CREs (carbapenem resistant Enterobacteriaceae)
- ALL are pathogens for humans
- Somatic (O) antigen and flagella (H) antigen, some with capsular (K) antigen
Term
E. coli
Definition
- major etio agent for UTI and AGE (acute gastroenteritis)
Term
Klebsiella pneumoniae
Definition
- antiphagocytic capsule for virulence
- SEVERE DESTRUCTIVE PNEUMONIA
- ICU infection - common as a secondary invader
- primary cause of nosocomial UTI
- epidemic diarrhea of newborn
- ESBL - KP
Term
ESBL/CREs
Definition
- cause bladder, lung and blood infections
- septic shock
- 50% mortality
- tx: some respond to two drugs, tigecycline and colistin (kidney damaging)
ESBL - carbapenem
Term
CRE - risk
Definition
- Healthy people do not carry CREs
- long term care residents
- patients who received Rx for other conditions
- vent
- foley, IVs
- long course antibiotics
Term
Enterobacteriaceae (3)
Definition
- salmonella
- typhoid fever
- gastroenteritis
- Shigella
- bacillary dysentery - inflammatory cells, blood in stool
- Vibro
- Cholera
Term
Enterobacter/Proteus
Definition
- Enterobacter cloacae
- Enterobacter aerogenes
- Nosocomial UTI
Term
Bacteroides
Definition
- ANAEROBIC gram negative
- bacteroides fragilis
- habitat of human GI - infxn occur below diaphragm, peritonitis, gyn infections
- abscess formation
- tx: flagyl (clindamycin)
Term
Psuedomonas
Definition
- Pseudomonas aeruginosa
- pts receiving long term antibiotics
- **wounds, burns, cystic fibrosis
- UTI, catheterization
- pulm infection, improperly maintained resp. therapy equipment
- immunosuppressed, nosocomial
Term
haemophilus, bordatella, zoonoses
Definition
- indigenous flora and pathogens
- H. influenzae - etio agent of respiratory and meningeal infection
- antigenic properties = capsules
- types = a,b,c,d,e,f - type b most common in kids
Term
Haemophilus pathogenicity - (3 kinds)
Definition
1. Haemophilus influenzae
- acute epiglottiditis (look for thumb sign on X-ray)
- Meningitis

2. Haemophilus aegyptius
- Conjunctivitis

3. Haemophilus ducreyi
- chancroid - HURTS
Term
Bordatella
Definition
- Bordetella pertussis
- Whooping cough / lapse of immunity
- 7-10 days after exposure
- Mild flu-like Sx (malaise rhinorrhea, cough)– Catarrhal stage
- Violent cough followed by insp whoop – paroxysmal stage,posttusssive emesis, occurs periods of weeks
- Gradual decrease in Sx – 2 to 4 weeks
tx: zithromax
Term
Bordatella Pertussis - Dx, Tx, Prevention
Definition
- Dx: PCR, serology, and culture
- Tx: Azithromycin, do not alter sx with eradication of organism
- Prevention: Tdap (tetanus, diphtheria, pertussis)
Term
Zoonoses***
Definition
- Pasteurella Multocida - bites
- Indigenous flora of resp tract, oropharynx of animals and birds
- TREAT CAT AND HUMAN BITES, not nec. dogs
GIVE AUGMENTIN AND CIPRO
Term
above abdomen?
Definition
clindamycin
Term
Below the abdomen?
Definition
flagyl
Term
chest?
Definition
zithromax
Term
Atypical mycobacterium
Definition
- USE A TB TYPE OF DRUG
M. marinum - chronic nodular lesions, fresh and salt water, swimming pool granuloma, fist
Term
Mycoplasma pneumonia
Definition
- walking pneumonia
- zithromax
Term
Listeria monocytogenes
Definition
Meningitis (>age 60) and sepsis
Neonates and immunocompromised
Meningitis of neonates as passes through birth canal
Intrauterine infection- still birth
Meningitis: Strep Pneumo, Nisseria M, Listeria
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