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Details

Gout Prophylactic Treatment
Gout Prophylactic Treatment
12
Pharmacology
Professional
09/02/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
MOA of allopurinol and febuxostat
Definition

xanthine oxidase inhibitors (block UA production)

Term
How should coclchicine be used during initial uric acid lowering therapy?
Definition

Use colchicine or NSAIDs for at least 6 months to reduce the risk of acute flares when beginning UA - lowering acid therapy.

Term
Brand name for Allopurinol
Definition
Zyloprim
Term
Brand name for Febuxostat
Definition
Uloric
Term
Allpurinol side effects of note?
Definition

precipitation of acute attacks

nausea

skin rash (can lead to SJS)

Term
Why isn't febuxostat used often
Definition

much more expensive than allopurinol (20k more/year). It may be safer in severe reneal impairment (no dose adjustment in reanlly impaired) and has a decreased risk for hypersensitivity.

Term
[image]
Definition
Statement. Not a question.
Term
[image]
Definition
Statement. Not a question.
Term
Can probenecid affect renal clearance
Definition

Probenecid may decrease the renal clearance of other medications taken concurrently, including aspirin, methotrexate, theophylline, penicillins &c.

 

Term
Probenecid used to be given with penicillins, why?
Definition

Probenecid used to be given with penicillin to increase the penicillin plasma concentrations; this will increase reactions associated with the beta lactam

Term

How should allopurinol be used to prevent gout attacks (probenecid is uesd less commonly)

Definition

Once daily with a meal to reduce stomach upset

Term
Are allopurinol's beneficial affects fast acting?
Definition

may take up to several weeks for this medicine to have an effect and one may have more gout attacks for several months after starting this medicine whilet he body removes extra uric acid.

 

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