Term
| What is the first step of Stage I Glycolysis? |
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Definition
Glucose-> Glucose 6-Phosphate
via hexokinase |
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Term
| What is the enzyme involved in the first step of Stage I Glycolysis? |
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Definition
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Term
| Although most tissues use Hexokinase I, II, or III what tissue uses Hexokinase IV? |
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Definition
| Hexokinase IV or Glucokinase is seen in the beta cells of the liver |
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Term
| What are the irreversible steps of Stage I Glycolysis? |
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Definition
Glucose -> Glucose 6-Phosphate via hexokinase
Fructose 6-phosphate-> Fructose 1,6-bisphosphate via phosphofructokinase-1 |
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Term
| G6P stands for what product? |
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Definition
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Term
| What is the second step of Stage I glycolysis? |
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Definition
Glucose 6-phosphate -> Fructose 6-Phosphate
via phosphoglucose isomerase |
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Term
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Definition
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Term
| What is the third step of Stage I glycolysis? |
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Definition
Fructose 6-phosphate -> Fructose 1-6-biphosphate
via phosphofructokinase-1 |
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Term
| What is the fourth step of Stage I glycolysis? |
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Definition
Splitting of Fructose 1,6-biphosphate -> Dihydroxyacetone phosphate (DHAP) and Glyceraldehyde 3-phosphate
via aldolase |
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Term
| What is the collective name for Dihydroxyacetone phosphate (DHAP) and Glyceraldehyde 3-phosphate (G3P)? |
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Definition
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Term
| Which of the triose phosphates is further catalyzed into pyruvate? |
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Definition
| Glyceraldehyde 3-phosphate (G3P) |
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Term
| What is the commited step of stage I glycolysis? |
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Definition
fructose 6-phosphate-> fructose 1,6-biphosphate
via phosphofructokinase-1 |
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Term
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Definition
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Term
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Definition
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Term
| In stage I glycolysis, how many ATP are consumed? |
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Definition
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Term
| How many irreversible steps in Stage 1 glycolysis? |
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Definition
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Term
| How many reversible steps in stage 1 glycolysis? |
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Definition
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Term
| What is the first step of Stage II Glycolysis? |
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Definition
Glyceraldehyde 3-phosphate (G3P)-> 1,3 biphosphoglycerate (1,3 BPG)
via Glyceraldehyde 3-phosphate dehydrogenase |
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Term
| What is the second step of Stage II Glycolysis? |
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Definition
1,3 biphosphoglycerate -> 3-Phosphoglycerate
via phosphoglycerate kinase |
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Term
| What is step 3 of stage II glycolysis? |
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Definition
3-phosphoglycerate -> 2-phosphoglycerate
via phosphoglyceromutase |
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Term
| What is the 4th step of Stage II glycolysis? |
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Definition
2-Phosphoglycerate -> Phosphoenolpyruvate
via Enolase |
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Term
| What is the 5th step of Stage II glycolysis? |
|
Definition
phosphoenolpyruvate -> pyruvate
via pyruvate kinase |
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Term
| what is the irreversible step of Stage II Glycolysis? |
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Definition
phosphenolpyruvate -> pyruvate
via pyruvate kinase |
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Term
| What is the first super high-energy intermediate in Stage II glycolysis? |
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Definition
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Term
| What is the second super high energy intermediate in Stage II glycolysis? |
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Definition
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Term
| What enzyme causes the first substrate level phosphorylation in stage II glycolysis? |
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Definition
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Term
| What enzyme causes the second substrate level phosphorylation in stage II glycolysis? |
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Definition
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Term
| What step is the only oxidation that occurs in glycolysis? |
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Definition
glyceraldehyde 3-phosphate -> 1,3 biphosphoglycerate
via glyceraldehyde 3-phosphate dehydrogenase |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Chronic hemolytic anemia combine with abnormally high 2,3 BPG would point to a genetic defect in what enzyme? |
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Definition
Pyruvate Kinase.
Remember: High 2,3 BPG would be indicative of a defect in an enzyme downstream of 2,3 BPG production |
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Term
| What are the clinical presentations of hemolytic anemia? |
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Definition
| Red-brown urine, low hematocrit, jaundice |
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Term
| What possible enzymes are affected given:chronic hemolytic anemia and abnormally low 2,3 BPG? |
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Definition
| Phosphoglucoisomerase, phosphofructokinase-1, or Triose Phosphate Isomerase |
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Term
| What possible enzymes could be defective given: chronic hemolytic anemia, abnormally low 2,3 BPG, and cardiomyopathy/muscular weakness? |
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Definition
| Phosphofructokinase 1, or Triose phosphate isomerase |
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Term
| Chronic hemolytic anemia, abnormally low BPG, Muscular weakness/cardiomyopathy, and progressive neurological disfunction point to a defect in what enzyme? |
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Definition
| Triose phosphate isomerase |
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