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Gluconeogenesis
Steps names, and enzymes
13
Biochemistry
Undergraduate 2
02/27/2012

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Cards

Term
Step1
Definition

activation of bicarbonate by ATP to form carboxy phosphate + ADP

Then release of CO2

Term
step 2
Definition
CO2 attacked by biotin and makes carboxy biotin, biotin swings arm and releases CO2 at second site.
Term
step 3
Definition

pyruvate --> OAA

biotin removes proton from pyruvate and makes enol form, which attacks CO2 and makes OAA

Term
step 4
Definition
OAA decarboxylates and attacks GTP taking on phosphate to make PEP (phosphoenol pyruvate) + GDP and CO2
Term
step 5
Definition

PEP--> 2-phosphoglycerate by enolase

 

Term
step 6
Definition

2-phosphoglycerate ---> 3-phosphoglycerate

phosphoglycerate mutase

Term
step 7
Definition

3-phosphoglycerate ---> 1,3-bisphosphoglycerate

phosphoglycerate kinase

Term
step 8
Definition

1,3- bisphosphoglycerate ---> GAP

glyceraldehyde-3-P dehydrogenase

NADH-> NAD+

Term
step 9
Definition

G3P <---> DHAP

TIM

Term
step 10
Definition

DHAP + GAP ---> fructose 1,6-bisphosphate

Aldolase

aldol condensation

by Lysine residue

Term
step 11
Definition

Fruc- 1,6-bisphosphate ---> fructose-6-P

Fructose 1,6-bisphosphatase

*different than glycolsis*

Term
step 12
Definition

fructose-6-P ---> glucose-6-P

phosphohexose isomerase

rearrangement

Term
step 13
Definition

glucose-6-P ---> glucose

glucose 6 phosphatase

*different than glycolysis*

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