Term
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Definition
Replacement during adrenal insufficiency or to suppress inflammation and immune response
Asthma
Topically
Arthritis, gout (usually methylprednisone) |
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Term
| Cortisol (hydrocortisone) |
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Definition
Major endogenous steroid
Half-life 8-12 hrs
Low gluco/mineralocorticoid activity |
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Term
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Definition
glucocorticoids inactive until metabolized by 11B-hydroxysteroid dehydrogenase
Give to pregnant women (Can't get into fetus) |
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Term
| Prednisolone, Methylprednisolone |
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Definition
Glucocorticoids
4-6 times more potent for anti-infl. activity than cortisol
Low mineralocorticoid activity |
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Term
|
Definition
High mineralocorticoid activity
Minimal glucocorticoid activity |
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Term
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Definition
More than 18 times more glucocorticoid activity than cortisol
NO mineralocorticoid activity |
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Term
| Inhaled glucocorticoids use |
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Definition
Deliver hi conc. to lung w/ less systemic toxicity
Fluticasone
Beclomethasone
Flunisolide
Triamcinolone |
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Term
| Glucocorticoid side effects |
|
Definition
Inc infxns
Inc glc levels -> DM
2ndary hyperPTism
Osteoporosis
Edema
Suppressed linear bone growth in kids
Steroid psychosis
Cushing's syndrome
Withdrawal "rebound" phenomenon
Myopathy |
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Term
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Definition
| Mineralocorticoid rec antagonist |
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Term
|
Definition
| Mineralocorticoid rec antagonist |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
| Beta2 adrenergic agonists |
|
Definition
Used in asthma for bronchodilatory effects
Not recommended for monotherapy since they do not treat inflammation |
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Term
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Definition
| Short-acting Beta2 adrenergic agonist |
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Term
|
Definition
| Short-acting Beta2 adrenergic agonist |
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Term
|
Definition
Inhibits mast cell degranulation
Prevention of mild/mod asthma attacks by reducing reactivity
Does not relieve acute Sx
Used w/ glucocorticoids for severe asthma
Side effects: bad taste, cough, wheezing, HA, bronchospasm |
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Term
|
Definition
Inhibits mast cell degranulation
Prevention of mild/mod asthma attacks by reducing reactivity
Does not relieve acute Sx
Used w/ glucocorticoids for severe asthma
Side effects: bad taste, cough, wheezing, HA, bronchospasm |
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Term
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Definition
| Long-acting Beta2 adrenergic agonist |
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Term
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Definition
| Long-acting Beta2 adrenergic agonist |
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Term
|
Definition
Methylxanthine used for asthma/COPD
Bronchodilates
Side effects similar to caffeine |
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Term
|
Definition
Methylxanthine used for asthma/COPD
Bronchodilator
Side effects similar to caffeine |
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Term
|
Definition
Muscarininc rec antagonist used in COPD, asthma
NO CNS side effects
Useful in pts who can't take Beta2 agon. (pts taking MAOIs or with arrythmias/angina) |
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Term
|
Definition
Leukotriene rec antagonist used for PROPHYLACTIC Rx of mild asthma
Minimal side effects: pulmonary infiltrates, skin rashes, vasculitis, neuropathy |
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Term
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Definition
Leukotriene rec antagonist used for PROPHYLACTIC Rx of mild asthma
Minimal side effects: pulmonary infiltrates, skin rashes, vasculitis, neuropathy |
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Term
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Definition
5-Lipoxygenase inh used for PROPYLACTIC Rx of mild asthma
Can elevate liver enz. in 5% of pts |
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Term
|
Definition
Humanized monoclonal Anti-IgE Ab used to dec need for other asthma Rxs
Administered IV or subcut every 2-4 wks
Reduces airway responsiveness by preventing IgE/rec interaction |
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