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Global Impact of Infectous Disease
Biowarefare/terrorism
49
Microbiology
Undergraduate 1
12/19/2010

Additional Microbiology Flashcards

 


 

Cards

Term
Bioterrorism vs. biowarefare
Definition

warefare - biological agents used on people to acheive a military objective

 

terrorism - to achieve civil disruption, panic, or to instigate a crime

Term
what guidelines does a biological agent have to have  to be a weapon? 4 of them
Definition
  1. economically reasonable
  2. capable of reaching intended target
  3. cause limited collateral damage
  4. to result in death
Term
name a couple early historical events of bilogical warfare?
Definition
  1. siege of Kaffa - hurled infected bodies over wall
  2. Romans poisoned wells
  3. Pontiacs rebellion - French and Indian War - gave indians variola laden blankets(smallpox)
Term
Geneva Protocal of 1925
Definition
  • banned the use of biological agents in war.
  • However treaty was never ratified by U.S. or Japan
Term
What did the Protocal fail to prohibit?
Definition
The production and storage of biological weapons
Term

ping Fan, Manchuria experiments?

what punishment did they recieve?

Definition
  • JApan invaded China and developed a major biological weapons production and testing center.
  • plague, anthrax, cholera
  • tested thousands of POW's, Chinese citizens
  • no crimes charged in exchange for BW data
Term
What is Camp Detrick and what is it used for?
Definition
1943 - developed in response to UK need for BW's in WWII. Still used for testing today
Term
Johnston Atoll - 1969?
Definition
  • did testing of BW agents on navy ships in middle of atlantic.
  • disseminated by Jets that would fly over
  • 50% kill rate considered good
Term
what impact did President Nixon have on BW program?
Definition
  • renounced BW due to protest of use of chemicals in Vietnam.
  • all offensive stocks of BW's gone by 1972
Term
What was the Biological Toxins and Weapons Convention of 1972 and was it effective?
Definition
  • banned all offensive stocks and programs for creating BW's
  • termination of such programs
  • Not effective: USSR continued assuming U.S. did as well.  Also no way to check to see if everyone was compying
Term
What was the Biopreparet?
Definition
  • Soviet BW program that was umbrella'ed as a NGO.
  • produced better BW's with more effective dispersal techniques
Term
Post BWC Soviet Program?
Definition
  • huge BW facility that had 4500 workers.
  • elaborate strains of every deadly agent out there
Term
what was Soviets mind of thought when they tried to eradicate the world of smallpox?
Definition
  • Biopreparet - wanted to make a smallpox attack that much more effective
  • had an extremely virulent strain produced taht would devastate the world with extremely efficient delivery systems
Term
Sverdlosk - 1979 what happenned?
Definition

accident at Soviet production facility

accidently released anthrax spores to the public

Term
As the Soviet Union fell what happenned?
Definition
  • BW programs went with other countries( Iraq, Iran)
  • funding cut
  • only some of BW's accounted for
Term
who had the 2nd largest BW facility?
Definition
South Africa
Term

Bioterrorism:

Dalles Oregon?

Diane Thompson?

Larry Wayne Harris?

Definition
  • spread shit on salad bars
  • spread dysentary on muffins for coworkers
  • Aryan Nation: if you arrest our guys you will get a test tube in the mail
Term
2001 anthrax incident
Definition
  • 11 inhalation- 5 died
  • 12 cutaneous- 0 died
  • 32,000 tested
  •  cost $6 billion
Term
Disadvantages of Bio WEapons?
Definition
  • unethical
  • hard to transport
  • difficult to control spread
  • pandoras box
Term
Overt vs. Covert event
Definition

Overt- event announced, microorg identified

 

Covert - unannounced, patients randomly fall ill, agent unknown

Term
3 categories of infectious agents based on what criteria?
Definition
  • A,B,C
  • based on transmission from human to human
  • ease to disseminate
  • ease of production
  • severity of infection
Term
category A, B, C
Definition
  • A - most severe, easy to disseminate, easy to produce, high transmission rate
  • B - 2nd severe, moderate to disseminate, moderate morbidity, low mortality
  • C - agents that could be engineered, easy to get and produce, potential for high mortality
Term
preparedness?
Definition
  • 155 million people susceptible to smallpox( under 38)
  • antidotes available
  • detection services -surveillance across nation
  • quick diagnostic test
Term

at first in 1982, thought virus could be due to what 3 things?

 

what proved this wrong?

Definition
  1. something in gay men
  2. amyl nitrate
  3. barage of STDs
  • IV drug users and heterosexuals got the virus
Term
AIDS stands for?
Definition
Acquired Immune Deficiency Syndrome
Term

once a daignostic blood test was developed in 1985 where was virus seen running rampid?

How were hemopheliacs getting infected?

Definition

WEst Africa

Blood supply was infected

Term
what was the first anti- retroviral drug
Definition
AZT 1987
Term
when did deaths due to AIDS finally start to drop in developing countries?
Definition
1996
Term
In 2000, what did the South African President Thabo Mbeki believe about AIDS?
Definition
That HIV was not the cause of AIDS. Dropped all programs
Term
What was PEPFAR
Definition
  • Presidents Emergency Plan for AIDS Relief
  • increased foreign aid to 15 countries for AIDS relief
Term
What is HAART.  What was found it caused that greatly reduced spread?
Definition
  • Highly Active Anti-Retroviral Treatment
  • don't spread HIV through sex when on this treatment plan
Term

Hows does AIDS affect:

-Immune System

-Nervous System

 

Definition
  • Immune - WBC counts and helper T cells are killed off and body loses ability to fight off infections and viruses
  • Nervous - infection can cross into brain and cause dementia, depression, slurred speach
Term
How has HIV changed Society?
Definition
  1. shattered idea that ID's conquered
  2. more open to homosexuality
  3. science gained knowledge on T cells and viral infections can be treated
  4. safe sex
Term
How does AIDS hinder development?
Definition
  • high health care cost overwhelming hospitals
  • hindering education, killing teachers
Term
what impediments exist to controlling HIV/AIDS?
Definition
  • people unaware of having disease(asymptomatic)
  • funding
  • no education on it
  • untruthful to partners
  • denialism
  • unwilling to get tested
  • treatment cost
  • no vaccine
Term
in the last 8 years why has funding increased so much?
Definition
  • AZT off patent
  • gates foundation
  • UNAIDS
  • Bono makes Jesse Helms cry
  • treatable wiht HAART
  • PEPFAR
  • Global Fund
Term
Early rule of haiti was by?
Definition

Spain, then taken over by France buccaneers

Western 1/3 then ceded to France in 1697

Term
Haiti Revolution?
Definition

1791 to 1804

  • unified Island and freed all slaves, became governor for life, Napoleon didnt like, Frances most profittable colony.
  • French regain control and killed Loverture, but troops all died due to ID

 

Term
Why did French troops die due to infectious disease?
Definition
  1. took control of ports. Next to swamps with tons of malaria
  2. burned cities therefore no medical supplies
  3. French troops not exposed to ID's in HAiti at time
Term
After Haiti was independent in 1804 why didnt they get foreign recognition?
Definition
  • racism
  • too unstable, rulers constantly assassinated
Term
What happenned when U.S. occupied Haiti?
Definition
  • only supported Haiti when the rulers in power were to the liking of the US and good for their economic interests
Term
what was the effect of the CDC putting one of the four HIV risk groups as Haiti?
Definition
  • killed tourism and reduced foreign trade
Term
how is the wealth distributed in Haiti?
Definition
50% of wealth is in 1% of (French white) population
Term
path to improved health is tied to?
Definition
  • poltical will is needed to improve healthcare system infrastructure, education to improve workforce, and increase food source
Term
how did the US recently help Haitian economy? food security?
Definition
  • all imports to US are duty free
  • hoping to jumpstart economy
  • rice imports from US tax went down 32%- hurt haitian agriculture though
Term
5 areas that need progress to eliminate infectious disease?
Definition
  1. combining efforts of multiple organizations to one effort
  2. develop healthcare infrastructure
  3. scientific development - vaccines etc.
  4. Religious, social, cultural considerations
  5. legal protection of groups/ confidentiality
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