Term
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Definition
-used to control acid secretion in the control of gastric ulceration
-block H2R on parietal cells, so block histamine stimulation of parietal cells and decr H+ release from parietal cell
(decr. basal and food stimulation H+ secretion)
e.g. cimetidine, ranitidine |
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Term
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Definition
-used to control acid secretion in the control of gastric ulceration
-block H2R on parietal cells, so block histamine stimulation of parietal cells and decr H+ release from parietal cell
(decr. basal and food stimulation H+ secretion) |
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Term
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Definition
Muscarinic antagonist - blocks muscarinic R on parietal cell so block H+ secretion directly
- blocks muscarinic R on ECL cell, which decr. histamine release and so decr. stimulation of parietal cell by hist. and decr H+ |
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Term
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Definition
| Block H+/K+ pump of parital cell so decr. H+ secretion - accumulates in areas of low pH so can effective for 2-3 days e.g. omeprazole |
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Term
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Definition
Neutralising drugs used in the tx. of gastric ulcers
e.g. sodium bicarbonate, aluminium salts |
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Term
| Sodium biacrobonate (NaHCO3-) |
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Definition
NaHCO3- + HCL --> NaCl+ H2CO3 --> H2O + CO2
i.e. HCl is diluted - soluble and fast acting but needs to be taken several times a day |
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Term
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Definition
Used to neutralise the stomach in prevention / treatment of gastric ulcers.
Al. hydroxide gel + HCl --> AlCl2
i.e. HCl neutralised
Gel is also protective
Can cause constipation and so combo w. magnesium salts (s. effects diarrhoe) and can cancel out |
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Term
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Definition
| protect the mucosa in gastric ulceration - a complex of sulphated sucrose and aluminium hydroxide - form complex gel w. mucus and coat the mucosa |
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Term
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Definition
used to protect the mucosa in gastric ulceration
-coats ulcer base
-absorbs pepsin
-enhances PG synthesis and so stimulates HCO3- secretion
-kills Helicobacter pylori |
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Term
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Definition
A PGE1 synthetic analogue - used to protect the mucosa in gastric ulceration - acts directly on paritel cells to decr. acid secretion
-maintains / incr mucosal blood supply
-incr. mucus and HCO3- secretion
-highly useful if ulcers associated w. NSAIDs |
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Term
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Definition
-anti-emetic D2R antagonist
-good at preventing vomiting caused by agents which directly stimulate the Chemical Trigger Zone
NB: also sedative |
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Term
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Definition
-anti-emetic D2R antagonist (and 5HT3)
-good at preventing vomiting caused by agents which directly stimulate the Chemical Trigger Zone
-also peripheral cholinergic actions - promote gastric emptying by inhibiting D2R in gut which would normally inhibit motility |
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Term
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Definition
| anti emetic w. H1R antagonist action - highlu effective against motion sickness and against stimuli acting locally in the stomach |
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Term
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Definition
| Anti-emetic - ACh-M antagonists - effective in motion sickness |
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Term
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Definition
Anti-emetic - 5HT3 antagonists - acts on chemical trigger zone
-extremely potent
-main effect possibly due to peripheral 5HT3 in gut
-esp. useful in cytotoxic induced vom |
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Term
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Definition
pro-kinetic drug used as anti-emetic
-stimulates M3R in gastric sm. muscle |
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